Mettl5 methyltransferase 5, N6-adenosine [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Mettl5provided by RGD
Official Full Name: methyltransferase 5, N6-adenosineprovided by RGD
Primary source: RGD:1566062
See related: EnsemblRapid:ENSRNOG00000008469 AllianceGenome:RGD:1566062
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: RGD1566062
Summary: Predicted to enable S-adenosyl-L-methionine binding activity and rRNA (adenine-N6-)-methyltransferase activity. Predicted to be involved in positive regulation of translation; rRNA methylation; and stem cell differentiation. Predicted to be located in several cellular components, including fibrillar center; postsynapse; and presynapse. Human ortholog(s) of this gene implicated in autosomal recessive intellectual developmental disorder 72. Orthologous to human METTL5 (methyltransferase 5, N6-adenosine). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Thymus (RPKM 205.1), Heart (RPKM 202.4) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 3q21

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	3	NC_086021.1 (75033605..75046359, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	3	NC_051338.1 (54625790..54638066, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	3	NC_005102.4 (56101597..56113823, complement)

Chromosome 3 - NC_086021.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables S-adenosyl-L-methionine binding	ISO Inferred from Sequence Orthology more info
enables nucleic acid binding	IEA Inferred from Electronic Annotation more info
enables rRNA (adenine-N6-)-methyltransferase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in positive regulation of translation	ISO Inferred from Sequence Orthology more info
involved_in rRNA methylation	ISO Inferred from Sequence Orthology more info
involved_in rRNA processing	ISO Inferred from Sequence Orthology more info
involved_in stem cell differentiation	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in fibrillar center	IEA Inferred from Electronic Annotation more info
located_in fibrillar center	ISO Inferred from Sequence Orthology more info
located_in nucleolus	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in postsynapse	ISO Inferred from Sequence Orthology more info
located_in presynapse	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: rRNA N6-adenosine-methyltransferase METTL5

Names: methyltransferase like 5; methyltransferase-like protein 5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001114181.1 → NP_001107653.1 rRNA N6-adenosine-methyltransferase METTL5

See identical proteins and their annotated locations for NP_001107653.1

Status: VALIDATED

Source sequence(s)

BC158754, CH473949

UniProtKB/TrEMBL

A6HM25, B0BNB3, F7FIR4

Related

ENSRNOP00000011304.5, ENSRNOT00000011303.7

Conserved Domains (1) summary

COG2263
Location:7 → 209

COG2263; Predicted RNA methylase [General function prediction only]

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086021.1 Reference GRCr8

Range

75033605..75046359 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063284401.1 → XP_063140471.1 rRNA N6-adenosine-methyltransferase METTL5 isoform X2

UniProtKB/TrEMBL

A6HM25, B0BNB3, F7FIR4
XM_063284400.1 → XP_063140470.1 rRNA N6-adenosine-methyltransferase METTL5 isoform X1
XM_039105726.2 → XP_038961654.1 rRNA N6-adenosine-methyltransferase METTL5 isoform X3

Conserved Domains (1) summary

COG2263
Location:7 → 171

COG2263; Predicted RNA methylase [General function prediction only]