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    Ttll7 tubulin tyrosine ligase-like family, member 7 [ Mus musculus (house mouse) ]

    Gene ID: 70892, updated on 4-Jan-2025

    Summary

    Official Symbol
    Ttll7provided by MGI
    Official Full Name
    tubulin tyrosine ligase-like family, member 7provided by MGI
    Primary source
    MGI:MGI:1918142
    See related
    Ensembl:ENSMUSG00000036745 AllianceGenome:MGI:1918142
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    mTTLL7; C630030B20; 1110049N09Rik; 4921517B04Rik
    Summary
    Enables tubulin-glutamic acid ligase activity. Involved in protein polyglutamylation. Located in 9+0 non-motile cilium and ciliary basal body. Is expressed in 1-cell stage embryo and 8-cell stage embryo. Orthologous to human TTLL7 (tubulin tyrosine ligase like 7). [provided by Alliance of Genome Resources, Jan 2025]
    Expression
    Biased expression in cerebellum adult (RPKM 11.7), cortex adult (RPKM 10.6) and 8 other tissues See more
    Orthologs
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    Genomic context

    See Ttll7 in Genome Data Viewer
    Location:
    3 H2; 3 72.28 cM
    Exon count:
    24
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (146557312..146690156)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (146852184..146984009)

    Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene protein kinase, cAMP dependent, catalytic, beta Neighboring gene capping protein (actin filament) muscle Z-line, alpha 1 pseudogene Neighboring gene ribosomal protein L11 pseudogene Neighboring gene STARR-seq mESC enhancer starr_09232 Neighboring gene STARR-positive B cell enhancer ABC_E6145 Neighboring gene STARR-seq mESC enhancer starr_09234 Neighboring gene predicted gene, 29771 Neighboring gene STARR-seq mESC enhancer starr_09235 Neighboring gene predicted gene, 36726 Neighboring gene STARR-seq mESC enhancer starr_09236 Neighboring gene peptidylprolyl isomerase A pseudogene 3_1528.1

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (4) 
    • Targeted (3)  1 citation

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding  
    enables alpha-tubulin binding  
    enables alpha-tubulin binding  
    enables beta-tubulin binding  
    enables beta-tubulin binding  
    enables metal ion binding  
    enables protein-glutamic acid ligase activity, elongating  
    enables protein-glutamic acid ligase activity, initiating  
    enables tubulin binding  
    enables tubulin-glutamic acid ligase activity  
    enables tubulin-glutamic acid ligase activity PubMed 
    enables tubulin-glutamic acid ligase activity PubMed 
    enables tubulin-glutamic acid ligase activity  
    Component Evidence Code Pubs
    located_in 9+0 non-motile cilium PubMed 
    is_active_in ciliary basal body  
    located_in ciliary basal body PubMed 
    located_in cytoplasm  
    located_in dendrite  
    located_in microtubule  
    located_in perikaryon  

    General protein information

    Preferred Names
    tubulin polyglutamylase TTLL7
    Names
    polyglutamylase
    tubulin--tyrosine ligase-like protein 7

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001302957.2NP_001289886.1  tubulin polyglutamylase TTLL7 isoform Ttll7

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (Ttll7).
      Source sequence(s)
      AC165225, AM690751, BP758417, CJ110550
      Consensus CDS
      CCDS51094.2
      UniProtKB/Swiss-Prot
      A4Q9E9, A4Q9F0, Q8C417, Q9D5V3
      UniProtKB/TrEMBL
      A0A0G2LB90
      Related
      ENSMUSP00000043753.8, ENSMUST00000037942.11
      Conserved Domains (1) summary
      pfam03133
      Location:91376
      TTL; Tubulin-tyrosine ligase family
    2. NM_001302958.1NP_001289887.1  tubulin polyglutamylase TTLL7 isoform Ttll7s

      See identical proteins and their annotated locations for NP_001289887.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks several 3' exons but includes an alternate 3' terminal exon, and it thus differs in the 3' coding region and 3' UTR, compared to variant 1. The encoded isoform (Ttll7s) has a distinct C-terminus and is shorter than isoform Ttll7.
      Source sequence(s)
      AK014905, AM690750, CJ110550
      UniProtKB/Swiss-Prot
      A4Q9F0
      Related
      ENSMUST00000038090.12
      Conserved Domains (1) summary
      pfam03133
      Location:91376
      TTL; Tubulin-tyrosine ligase family
    3. NM_001357217.1NP_001344146.1  tubulin polyglutamylase TTLL7 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC115889, AC165225, BM899995
      Consensus CDS
      CCDS89701.1
      UniProtKB/TrEMBL
      E9PWB8, E9Q6C6
      Related
      ENSMUSP00000101740.2, ENSMUST00000106134.4
      Conserved Domains (1) summary
      pfam03133
      Location:91376
      TTL; Tubulin-tyrosine ligase family

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000069.7 Reference GRCm39 C57BL/6J

      Range
      146557312..146690156
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036163314.1XP_036019207.1  tubulin polyglutamylase TTLL7 isoform X3

      UniProtKB/Swiss-Prot
      A4Q9E9, A4Q9F0, Q8C417, Q9D5V3
      Conserved Domains (1) summary
      pfam03133
      Location:91376
      TTL; Tubulin-tyrosine ligase family
    2. XM_036163315.1XP_036019208.1  tubulin polyglutamylase TTLL7 isoform X4

      UniProtKB/TrEMBL
      E9PWB8
      Conserved Domains (1) summary
      pfam03133
      Location:91376
      TTL; Tubulin-tyrosine ligase family
    3. XM_036163312.1XP_036019205.1  tubulin polyglutamylase TTLL7 isoform X1

      UniProtKB/Swiss-Prot
      A4Q9E9, A4Q9F0, Q8C417, Q9D5V3
      Conserved Domains (1) summary
      pfam03133
      Location:91376
      TTL; Tubulin-tyrosine ligase family
    4. XM_036163313.1XP_036019206.1  tubulin polyglutamylase TTLL7 isoform X2

      UniProtKB/TrEMBL
      E9PWB8
      Conserved Domains (1) summary
      pfam03133
      Location:91376
      TTL; Tubulin-tyrosine ligase family

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