SNX1 sorting nexin 1 [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Official Symbol: SNX1
Official Full Name: sorting nexin 1
Primary source: TAIR:AT5G06140
Locus tag: AT5G06140
See related: Araport:AT5G06140
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: ARABIDOPSIS THALIANA SORTING NEXIN 1; ATSNX1; K16F4.11; K16F4_11; sorting nexin 1
Summary: Homolog of yeast retromer subunit VPS5. Part of a retromer-like protein complex involved in endosome to lysosome protein transport. In roots it co-localizes with the PIN2 auxin efflux carrier. Involved in endocytic sorting of membrane proteins including PIN2, BOR1 and BRI1.
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Genomic context

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See SNX1 in Genome Data Viewer

Location:: chromosome: 5

Exon count:: 10

Sequence:: Chromosome: 5; NC_003076.8 (1855995..1858903, complement)

Chromosome 5 - NC_003076.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003076.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The plant-unique protein DRIF1 coordinates with sorting nexin 1 to regulate membrane protein homeostasis.
Title: The plant-unique protein DRIF1 coordinates with sorting nexin 1 to regulate membrane protein homeostasis.
The Arabidopsis SNX1 protein is involved in recycling the iron transporter IRT1, thus promoting its presence at the plasma membrane.
Title: SNX1-mediated protein recycling: Piecing together the tissue-specific regulation of arabidopsis iron acquisition.
overexpression of FAB1A-GFP reassembles SNX2b-mRFP on the endosomal membrane despite the absence of SNX1.
Title: Overexpression of FAB1A-GFP recruits SNX2b on the endosome membrane in snx1-1 mutant in Arabidopsis.
A loss of FAB1 function causes the release of late endosomal proteins, Ara7, and SNX1 from the endosome membrane, indicating that FAB1, or its product PtdIns(3,5)P2, mediates the maturation process of the late endosomes.
Title: Phosphatidylinositol 3-Phosphate 5-Kinase, FAB1/PIKfyve Kinase Mediates Endosome Maturation to Establish Endosome-Cortical Microtubule Interaction in Arabidopsis.
High temperature selectively promotes the retrieval of PIN2 from late endosomes and sorts them to the plasma membrane through an endosomal trafficking pathway dependent on SORTING NEXIN1.
Title: Cellular auxin homeostasis under high temperature is regulated through a sorting NEXIN1-dependent endosomal trafficking pathway.
Our results reveal a role of SNX1 for the correct trafficking of IRT1 and, thus, for modulating the activity of the iron uptake machinery
Title: SORTING NEXIN1 is required for modulating the trafficking and stability of the Arabidopsis IRON-REGULATED TRANSPORTER1.
SNX1 phosphorylation is required for Arabidopsis seedling growth.
Title: Quantitative phosphoproteomics after auxin-stimulated lateral root induction identifies an SNX1 protein phosphorylation site required for growth.
the microtubule-associated protein CLASP interacts with the retromer component sorting nexin 1 (SNX1) to mediate an association between endosomes and microtubules.
Title: CLASP interacts with sorting nexin 1 to link microtubules and auxin transport via PIN2 recycling in Arabidopsis thaliana.
A combination of immunoelectron and fluorescence microscopy show that sorting nexin 1 (SNX1)localize to the trans-Golgi network (TGN), which is considered to represent the early endosome of plants.
Title: Retromer recycles vacuolar sorting receptors from the trans-Golgi network.
Arabidopsis thaliana SORTING NEXIN 1 (AtSNX1) is involved in the auxin pathway and that PIN2, but not PIN1 or AUX1, is transported through AtSNX1-containing endosomes [AtSNX1]
Title: AtSNX1 defines an endosome for auxin-carrier trafficking in Arabidopsis.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

NM_120696.4

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables phosphatidylinositol binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within Golgi to vacuole transport	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within endosome to lysosome transport	ISS Inferred from Sequence or Structural Similarity more info	PubMed
acts_upstream_of_or_within endosome to lysosome transport	TAS Traceable Author Statement more info	PubMed
acts_upstream_of_or_within positive gravitropism	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within protein localization to plasma membrane	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within protein targeting to vacuole	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within root development	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in chloroplast	ISM Inferred from Sequence Model more info
located_in endosome	IDA Inferred from Direct Assay more info	PubMed
located_in intracellular membrane-bounded organelle	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	IDA Inferred from Direct Assay more info	PubMed
located_in multivesicular body	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	HDA more info	PubMed
part_of retromer complex	IDA Inferred from Direct Assay more info	PubMed
part_of retromer complex	ISS Inferred from Sequence or Structural Similarity more info	PubMed

General protein information

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Preferred Names: sorting nexin 1

NP_196232.1

sorting nexin 1 (SNX1); FUNCTIONS IN: phosphoinositide binding; INVOLVED IN: in 7 processes; LOCATED IN: endosome, microsome, retromer complex, membrane, multivesicular body; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 14 growth stages; CONTAINS InterPro DOMAIN/s: Vps5 C-terminal (InterPro:IPR015404), Phox-like (InterPro:IPR001683); BEST Arabidopsis thaliana protein match is: sorting nexin 2B (TAIR:AT5G07120.1); Has 1807 Blast hits to 1807 proteins in 277 species: Archae - 0; Bacteria - 0; Metazoa - 736; Fungi - 347; Plants - 385; Viruses - 0; Other Eukaryotes - 339 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003076.8 Reference assembly

Range

1855995..1858903 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_120696.4 → NP_196232.1 sorting nexin 1 [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_196232.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q8RXM2, Q9FG38

UniProtKB/TrEMBL

A0A178UD05, A0A5S9Y239

Conserved Domains (2) summary

cd06859
Location:26 → 139

PX_SNX1_2_like; The phosphoinositide binding Phox Homology domain of Sorting Nexins 1 and 2

cd07596
Location:184 → 394

BAR_SNX; The Bin/Amphiphysin/Rvs (BAR) domain of Sorting Nexins