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    Methylenetetrahydrofolate reductase family protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 833862, updated on 18-Sep-2024

    Summary

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    Official Full Name
    Methylenetetrahydrofolate reductase family protein
    Primary source
    TAIR:AT5G38710
    Locus tag
    AT5G38710
    See related
    Araport:AT5G38710
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    MKD10.10; MKD10_10
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    Genomic context

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    Location:
    chromosome: 5
    Exon count:
    4
    Sequence:
    Chromosome: 5; NC_003076.8 (15501126..15504269)

    Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene cotton fiber protein Neighboring gene pseudo Neighboring gene miscRNA Neighboring gene ribosomal RNA-processing 7 protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003076.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Non-redundant functions of two proline dehydrogenase isoforms in Arabidopsis. Funck D, et al. BMC Plant Biol, 2010 Apr 19. PMID 20403182, Free PMC Article
    2. Differential control and function of Arabidopsis ProDH1 and ProDH2 genes on infection with biotrophic and necrotrophic pathogens. Rizzi YS, et al. Mol Plant Pathol, 2017 Oct. PMID 27526663, Free PMC Article
    3. Sequence and analysis of chromosome 5 of the plant Arabidopsis thaliana. Tabata S, et al. Nature, 2000 Dec 14. PMID 11130714

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. ProDH1 and ProDH2 are both necessary to achieve maximum resistance against Pseudomonas syringae pv. tomato AvrRpm1 and B. cinerea.[ProDH2]
      Title: Differential control and function of Arabidopsis ProDH1 and ProDH2 genes on infection with biotrophic and necrotrophic pathogens.
    2. ProDH2 may play an important role in Proline homeostasis in the vasculature, especially under stress conditions that promote Proline accumulation. [ProDH2]
      Title: Non-redundant functions of two proline dehydrogenase isoforms in Arabidopsis.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    NM_001344262.1
    NM_123232.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables proline dehydrogenase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables proline dehydrogenase activity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in proline catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in proline catabolic process IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in proline catabolic process to glutamate IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in response to osmotic stress IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in response to water deprivation IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrion ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    Methylenetetrahydrofolate reductase family protein
    NP_198687.1
    • Methylenetetrahydrofolate reductase family protein; FUNCTIONS IN: proline dehydrogenase activity; INVOLVED IN: oxidation reduction, proline catabolic process, glutamate biosynthetic process; EXPRESSED IN: 21 plant structures; EXPRESSED DURING: 12 growth stages; CONTAINS InterPro DOMAIN/s: Proline dehydrogenase (InterPro:IPR002872), Proline oxidase (InterPro:IPR015659); BEST Arabidopsis thaliana protein match is: Methylenetetrahydrofolate reductase family protein (TAIR:AT3G30775.1); Has 1807 Blast hits to 1807 proteins in 277 species: Archae - 0; Bacteria - 0; Metazoa - 736; Fungi - 347; Plants - 385; Viruses - 0; Other Eukaryotes - 339 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003076.8 Reference assembly

      Range
      15501126..15504269
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_123232.3 → NP_198687.1  Methylenetetrahydrofolate reductase family protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_198687.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q6NKX1, Q9FKR5
      UniProtKB/TrEMBL
      A0A178UQV1
      Conserved Domains (2) summary
      PLN02681
      Location:19 → 476
      PLN02681; proline dehydrogenase
      pfam01619
      Location:226 → 456
      Pro_dh; Proline dehydrogenase

    2. NM_001344262.1 → NP_001330954.1  Methylenetetrahydrofolate reductase family protein [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178UQV1, A0A1P8BCG0
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6NKX1.1

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