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    MKK3 mitogen-activated protein kinase kinase 3 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 834042, updated on 25-Sep-2024

    Summary

    Official Symbol
    MKK3
    Official Full Name
    mitogen-activated protein kinase kinase 3
    Primary source
    TAIR:AT5G40440
    Locus tag
    AT5G40440
    See related
    Araport:AT5G40440
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ATMKK3; mitogen-activated protein kinase kinase 3; MPO12.150; MPO12_150
    Summary
    Encodes a mitogen-activated protein kinase kinase. Activates MPK8.
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    Genomic context

    See MKK3 in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    10
    Sequence:
    Chromosome: 5; NC_003076.8 (16181628..16184827)

    Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene myb domain protein 22 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene A-kinase anchor-like protein Neighboring gene ncRNA Neighboring gene cyclin-dependent kinase inhibitor SMR3-like protein

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    NM_001344328.1
    NM_001344330.1
    NM_001344331.1
    NM_001344332.1
    NM_123408.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables MAP kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables MAP kinase kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables MAP kinase kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in chloroplast ISM
    Inferred from Sequence Model
    more info
     
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in extracellular region ISM
    Inferred from Sequence Model
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    mitogen-activated protein kinase kinase 3
    NP_001318713.1
    • mitogen-activated protein kinase kinase 3 (MKK3); CONTAINS InterPro DOMAIN/s: Protein kinase, ATP binding site (InterPro:IPR017441), Nuclear transport factor 2, Eukaryote (InterPro:IPR018222), Protein kinase, catalytic domain (InterPro:IPR000719), Serine/threonine-protein kinase domain (InterPro:IPR002290), Serine/threonine-protein kinase-like domain (InterPro:IPR017442), Protein kinase-like domain (InterPro:IPR011009), Serine/threonine-protein kinase, active site (InterPro:IPR008271); BEST Arabidopsis thaliana protein match is: MAP kinase kinase 6 (TAIR:AT5G56580.1); Has 122843 Blast hits to 121436 proteins in 4056 species: Archae - 133; Bacteria - 13736; Metazoa - 45702; Fungi - 12099; Plants - 30883; Viruses - 510; Other Eukaryotes - 19780 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003076.8 Reference assembly

      Range
      16181628..16184827
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001344329.1NP_001332251.1  mitogen-activated protein kinase kinase 3 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178UF93, A0A1P8BGD1
    2. NM_001344328.1NP_001318713.1  mitogen-activated protein kinase kinase 3 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O80396
      UniProtKB/TrEMBL
      A0A178UF93
      Conserved Domains (2) summary
      cd06623
      Location:80344
      PKc_MAPKK_plant_like; Catalytic domain of Plant dual-specificity Mitogen-Activated Protein Kinase Kinases and similar proteins
      cd00780
      Location:362461
      NTF2; Nuclear transport factor 2 (NTF2) domain plays an important role in the trafficking of macromolecules, ions and small molecules between the cytoplasm and nucleus. This bi-directional transport of macromolecules across the nuclear envelope requires many ...
    3. NM_001344330.1NP_001332252.1  mitogen-activated protein kinase kinase 3 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178UF93, A0A1P8BGD1
    4. NM_123408.3NP_198860.1  mitogen-activated protein kinase kinase 3 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_198860.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O80396
      UniProtKB/TrEMBL
      A0A178UF93
      Conserved Domains (2) summary
      cd06623
      Location:80344
      PKc_MAPKK_plant_like; Catalytic domain of Plant dual-specificity Mitogen-Activated Protein Kinase Kinases and similar proteins
      cd00780
      Location:362461
      NTF2; Nuclear transport factor 2 (NTF2) domain plays an important role in the trafficking of macromolecules, ions and small molecules between the cytoplasm and nucleus. This bi-directional transport of macromolecules across the nuclear envelope requires many ...
    5. NM_001344331.1NP_001332249.1  mitogen-activated protein kinase kinase 3 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178UF93, A0A1P8BGC3
      Conserved Domains (2) summary
      cd06623
      Location:2262
      PKc_MAPKK_plant_like; Catalytic domain of Plant dual-specificity Mitogen-Activated Protein Kinase Kinases and similar proteins
      cd00780
      Location:280379
      NTF2; Nuclear transport factor 2 (NTF2) domain plays an important role in the trafficking of macromolecules, ions and small molecules between the cytoplasm and nucleus. This bi-directional transport of macromolecules across the nuclear envelope requires many ...
    6. NM_001344332.1NP_001332250.1  mitogen-activated protein kinase kinase 3 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178UF93, A0A1P8BGD1