UK/UPRT1 uridine kinase/uracil phosphoribosyltransferase 1 [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Official Symbol: UK/UPRT1
Official Full Name: uridine kinase/uracil phosphoribosyltransferase 1
Primary source: TAIR:AT5G40870
Locus tag: AT5G40870
See related: Araport:AT5G40870
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: ATUK/UPRT1; MHK7.10; MHK7_10; UKL1; URIDINE KINASE-LIKE 1; uridine kinase/uracil phosphoribosyltransferase 1
Summary: Encodes a protein that with uridine kinase but not uracil phosphoribosyltransferase activities.
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Genomic context

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See UK/UPRT1 in Genome Data Viewer

Location:: chromosome: 5

Exon count:: 14

Sequence:: Chromosome: 5; NC_003076.8 (16374799..16378652)

Chromosome 5 - NC_003076.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003076.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Unlike single gene mutants, the ukl1 ukl2 double mutant has severe developmental defects and reduced biomass accumulation, indicating these enzymes catalyze redundant reactions.
Title: Plastid uridine salvage activity is required for photoassimilate allocation and partitioning in Arabidopsis.
AtUK/UPRT1 has a dual role in coding for both uridine kinase and uracil phosphoribosyltransferase that form UMP through the pyrimidine salvage pathway in Arabidopsis.
Title: Functional characterization of a gene encoding a dual domain for uridine kinase and uracil phosphoribosyltransferase in Arabidopsis thaliana.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

NM_123452.5

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
NOT enables uracil phosphoribosyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables uracil phosphoribosyltransferase activity	IGI Inferred from Genetic Interaction more info	PubMed
enables uridine kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables uridine kinase activity	IGI Inferred from Genetic Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in CTP salvage	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within UMP salvage	IDA Inferred from Direct Assay more info	PubMed
involved_in UMP salvage	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of starch metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in chloroplast	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: uridine kinase/uracil phosphoribosyltransferase 1

NP_198903.1

uridine kinase/uracil phosphoribosyltransferase 1 (UK/UPRT1); FUNCTIONS IN: uridine kinase activity, uracil phosphoribosyltransferase activity, kinase activity, ATP binding; INVOLVED IN: biosynthetic process, nucleoside metabolic process, metabolic process; LOCATED IN: cytoplasm; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Phosphoribulokinase/uridine kinase (InterPro:IPR006083), Phosphoribosyltransferase (InterPro:IPR000836), Uridine kinase (InterPro:IPR000764); BEST Arabidopsis thaliana protein match is: uridine kinase-like 2 (TAIR:AT3G27190.1); Has 1807 Blast hits to 1807 proteins in 277 species: Archae - 0; Bacteria - 0; Metazoa - 736; Fungi - 347; Plants - 385; Viruses - 0; Other Eukaryotes - 339 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003076.8 Reference assembly

Range

16374799..16378652

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_123452.5 → NP_198903.1 uridine kinase/uracil phosphoribosyltransferase 1 [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_198903.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q8RXX1, Q9FKS0

UniProtKB/TrEMBL

A0A178UHR6, A0A5S9YA64, A0A654G7T9

Conserved Domains (2) summary

cd02023
Location:64 → 262

UMPK; Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway, ...

pfam14681
Location:280 → 481

UPRTase; Uracil phosphoribosyltransferase