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    HCT hydroxycinnamoyl-CoA shikimate/quinate hydroxycinnamoyl transferase [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 834951, updated on 18-Sep-2024

    Summary

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    Official Symbol
    HCT
    Official Full Name
    hydroxycinnamoyl-CoA shikimate/quinate hydroxycinnamoyl transferase
    Primary source
    TAIR:AT5G48930
    Locus tag
    AT5G48930
    See related
    Araport:AT5G48930
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    hydroxycinnamoyl-CoA shikimate/quinate hydroxycinnamoyl transferase; K19E20.4; K19E20_4
    Summary
    At5g48930 has been shown to encode for the hydroxycinnamoyl-Coenzyme A shikimate/quinate hydroxycinnamoyltransferase (HCT) both synthesizing and catabolizing the hydroxycinnamoylesters (coumaroyl/caffeoyl shikimate and quinate) involved in the phenylpropanoid pathway. Influence on the accumulation of flavonoids which in turn inhibit auxin transport and reduce plant growth.
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    Genomic context

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    See HCT in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    2
    Sequence:
    Chromosome: 5; NC_003076.8 (19836299..19838235, complement)

    Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene Pentatricopeptide repeat (PPR) superfamily protein Neighboring gene tracheary element differentiation-related 7 Neighboring gene Leucine-rich repeat transmembrane protein kinase family protein Neighboring gene low-molecular-weight cysteine-rich 46

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003076.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Dynamic Conformational States Dictate Selectivity toward the Native Substrate in a Substrate-Permissive Acyltransferase. Levsh O, et al. Biochemistry, 2016 Nov 15. PMID 27805809, Free PMC Article
    2. Flavonoid accumulation in Arabidopsis repressed in lignin synthesis affects auxin transport and plant growth. Besseau S, et al. Plant Cell, 2007 Jan. PMID 17237352, Free PMC Article
    3. Silencing of hydroxycinnamoyl-coenzyme A shikimate/quinate hydroxycinnamoyltransferase affects phenylpropanoid biosynthesis. Hoffmann L, et al. Plant Cell, 2004 Jun. PMID 15161961, Free PMC Article
    4. Protein-protein and protein-membrane associations in the lignin pathway. Bassard JE, et al. Plant Cell, 2012 Nov. PMID 23175744, Free PMC Article
    5. Tandem affinity purification and mass spectrometric analysis of ubiquitylated proteins in Arabidopsis. Saracco SA, et al. Plant J, 2009 Jul. PMID 19292762, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_124270.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables quinate O-hydroxycinnamoyltransferase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables shikimate O-hydroxycinnamoyltransferase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within lignin biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within positive regulation of flavonoid biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm ISM
    Inferred from Sequence Model
    more info
    		  
    located_in membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    hydroxycinnamoyl-CoA shikimate/quinate hydroxycinnamoyl transferase
    NP_199704.1
    • hydroxycinnamoyl-CoA shikimate/quinate hydroxycinnamoyl transferase (HCT); CONTAINS InterPro DOMAIN/s: Transferase (InterPro:IPR003480); BEST Arabidopsis thaliana protein match is: HXXXD-type acyl-transferase family protein (TAIR:AT5G57840.1); Has 1807 Blast hits to 1807 proteins in 277 species: Archae - 0; Bacteria - 0; Metazoa - 736; Fungi - 347; Plants - 385; Viruses - 0; Other Eukaryotes - 339 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003076.8 Reference assembly

      Range
      19836299..19838235 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_124270.4 → NP_199704.1  hydroxycinnamoyl-CoA shikimate/quinate hydroxycinnamoyl transferase [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_199704.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8LFT5, Q9FI78
      UniProtKB/TrEMBL
      A0A178UBG1
      Conserved Domains (1) summary
      PLN02663
      Location:1 → 433
      PLN02663; hydroxycinnamoyl-CoA:shikimate/quinate hydroxycinnamoyltransferase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9FI78.1

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