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    BAG1 BCL-2-associated athanogene 1 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 835281, updated on 18-Sep-2024

    Summary

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    Official Symbol
    BAG1
    Official Full Name
    BCL-2-associated athanogene 1
    Primary source
    TAIR:AT5G52060
    Locus tag
    AT5G52060
    See related
    Araport:AT5G52060
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ATBAG1; BCL-2-associated athanogene 1; MSG15.15; MSG15_15
    Summary
    A member of Arabidopsis BAG (Bcl-2-associated athanogene) proteins, plant homologs of mammalian regulators of apoptosis. Plant BAG proteins are multi-functional and remarkably similar to their animal counterparts, as they regulate apoptotic-like processes ranging from pathogen attack, to abiotic stress, to plant development.
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    Genomic context

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    See BAG1 in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    4
    Sequence:
    Chromosome: 5; NC_003076.8 (21152011..21154395, complement)

    Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene miscRNA Neighboring gene pseudo Neighboring gene ncRNA Neighboring gene pseudo

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003076.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Arabidopsis BAG1 Functions as a Cofactor in Hsc70-Mediated Proteasomal Degradation of Unimported Plastid Proteins. Lee DW, et al. Mol Plant, 2016 Oct 10. PMID 27343446
    2. Structural insight into plant programmed cell death mediated by BAG proteins in Arabidopsis thaliana. Fang S, et al. Acta Crystallogr D Biol Crystallogr, 2013 Jun. PMID 23695238
    3. Experimental analysis of the Arabidopsis mitochondrial proteome highlights signaling and regulatory components, provides assessment of targeting prediction programs, and indicates plant-specific mitochondrial proteins. Heazlewood JL, et al. Plant Cell, 2004 Jan. PMID 14671022, Free PMC Article
    4. Sequence and analysis of chromosome 5 of the plant Arabidopsis thaliana. Tabata S, et al. Nature, 2000 Dec 14. PMID 11130714

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_124585.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein-folding chaperone binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within cytoplasm protein quality control by the ubiquitin-proteasome system IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrion HDA PubMed 
    located_in mitochondrion ISM
    Inferred from Sequence Model
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    BCL-2-associated athanogene 1
    NP_200019.2
    • BCL-2-associated athanogene 1 (BAG1); INVOLVED IN: regulation of apoptosis, apoptosis; LOCATED IN: mitochondrion; EXPRESSED IN: 22 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Apoptosis regulator, Bcl-2 protein, BAG (InterPro:IPR003103), Ubiquitin supergroup (InterPro:IPR019955); BEST Arabidopsis thaliana protein match is: BCL-2-associated athanogene 3 (TAIR:AT5G07220.1); Has 385 Blast hits to 385 proteins in 61 species: Archae - 0; Bacteria - 4; Metazoa - 126; Fungi - 8; Plants - 222; Viruses - 0; Other Eukaryotes - 25 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003076.8 Reference assembly

      Range
      21152011..21154395 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_124585.4 → NP_200019.2  BCL-2-associated athanogene 1 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_200019.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q0WUQ1, Q9FJ86
      UniProtKB/TrEMBL
      A0A178USB0, A0A5S9YD75, A0A654GA62
      Conserved Domains (2) summary
      cd17054
      Location:66 → 135
      Ubl_AtBAG1_like; ubiquitin-like (Ubl) domain found in Arabidopsis thaliana Bcl-2-associated athanogenes AtBAG1, AtBAG2, AtBAG3, AtBAG4, and similar proteins
      pfam02179
      Location:161 → 237
      BAG; BAG domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q0WUQ1.1

    Gene LinkOut

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