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    PLC4 phosphatidylinositol-speciwc phospholipase C4 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 835984, updated on 18-Sep-2024

    Summary

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    Official Symbol
    PLC4
    Official Full Name
    phosphatidylinositol-speciwc phospholipase C4
    Primary source
    TAIR:AT5G58700
    Locus tag
    AT5G58700
    See related
    Araport:AT5G58700
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ATPLC4; MZN1.19; MZN1_19; phosphatidylinositol-speciwc phospholipase C4
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    Genomic context

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    See PLC4 in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    11
    Sequence:
    Chromosome: 5; NC_003076.8 (23712827..23716391, complement)

    Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene ARM repeat superfamily protein Neighboring gene phosphatidylinositol-speciwc phospholipase C5 Neighboring gene rotamase CYP 7 Neighboring gene smr (Small MutS Related) domain-containing protein Neighboring gene pfkB-like carbohydrate kinase family protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003076.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Stress- and phospholipid signalling responses in Arabidopsis PLC4-KO and -overexpression lines under salt- and osmotic stress. van Hooren M, et al. Phytochemistry, 2023 Dec. PMID 37734512
    2. Arabidopsis phosphoinositide-specific phospholipase C 4 negatively regulates seedling salt tolerance. Xia K, et al. Plant Cell Environ, 2017 Aug. PMID 28102910
    3. Petunia phospholipase c1 is involved in pollen tube growth. Dowd PE, et al. Plant Cell, 2006 Jun. PMID 16648366, Free PMC Article
    4. ABC transporter PEN3/PDR8/ABCG36 interacts with calmodulin that, like PEN3, is required for Arabidopsis nonhost resistance. Campe R, et al. New Phytol, 2016 Jan. PMID 26315018
    5. Sequence and analysis of chromosome 5 of the plant Arabidopsis thaliana. Tabata S, et al. Nature, 2000 Dec 14. PMID 11130714

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Stress- and phospholipid signalling responses in Arabidopsis PLC4-KO and -overexpression lines under salt- and osmotic stress.
      Title: Stress- and phospholipid signalling responses in Arabidopsis PLC4-KO and -overexpression lines under salt- and osmotic stress.
    2. AtPLC4 negatively regulates the salt tolerance of Arabidopsis seedlings, and Ca(2+) may be involved in regulating this process.
      Title: Arabidopsis phosphoinositide-specific phospholipase C 4 negatively regulates seedling salt tolerance.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_001037020.2
    NM_001345319.1
    NM_125257.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables phosphatidylinositol phospholipase C activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in intracellular signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in mitochondrion ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    phosphatidylinositol-speciwc phospholipase C4
    NP_001032097.1
    • phosphatidylinositol-speciwc phospholipase C4 (PLC4); FUNCTIONS IN: phosphoinositide phospholipase C activity, phospholipase C activity, phosphoric diester hydrolase activity; INVOLVED IN: signal transduction, intracellular signaling pathway, lipid metabolic process; LOCATED IN: plasma membrane; EXPRESSED IN: 22 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: Phospholipase C, phosphatidylinositol-specific, X domain (InterPro:IPR000909), C2 calcium/lipid-binding domain, CaLB (InterPro:IPR008973), Phospholipase C, phosphoinositol-specific (InterPro:IPR001192), Phospholipase C, phosphatidylinositol-specific, Y domain (InterPro:IPR001711), PLC-like phosphodiesterase, TIM beta/alpha-barrel domain (InterPro:IPR017946), C2 membrane targeting protein (InterPro:IPR018029), C2 calcium-dependent membrane targeting (InterPro:IPR000008); BEST Arabidopsis thaliana protein match is: Phosphoinositide-specific phospholipase C family protein (TAIR:AT2G40116.1); Has 2441 Blast hits to 1951 proteins in 262 species: Archae - 0; Bacteria - 0; Metazoa - 1601; Fungi - 365; Plants - 252; Viruses - 0; Other Eukaryotes - 223 (source: NCBI BLink).
    NP_001318832.1
    • phosphatidylinositol-speciwc phospholipase C4 (PLC4); FUNCTIONS IN: phospholipase C activity, phosphoinositide phospholipase C activity, phosphoric diester hydrolase activity; INVOLVED IN: signal transduction, intracellular signaling pathway, lipid metabolic process; LOCATED IN: plasma membrane; EXPRESSED IN: 22 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: Phospholipase C, phosphoinositol-specific, EF-hand-like (InterPro:IPR015359), Phospholipase C, phosphatidylinositol-specific, X domain (InterPro:IPR000909), C2 calcium/lipid-binding domain, CaLB (InterPro:IPR008973), Phospholipase C, phosphoinositol-specific (InterPro:IPR001192), Phospholipase C, phosphatidylinositol-specific, Y domain (InterPro:IPR001711), PLC-like phosphodiesterase, TIM beta/alpha-barrel domain (InterPro:IPR017946), C2 membrane targeting protein (InterPro:IPR018029), C2 calcium-dependent membrane targeting (InterPro:IPR000008); BEST Arabidopsis thaliana protein match is: Phosphoinositide-specific phospholipase C family protein (TAIR:AT2G40116.1); Has 2449 Blast hits to 1960 proteins in 260 species: Archae - 0; Bacteria - 0; Metazoa - 1604; Fungi - 359; Plants - 253; Viruses - 0; Other Eukaryotes - 233 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003076.8 Reference assembly

      Range
      23712827..23716391 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001345319.1 → NP_001318832.1  phosphatidylinositol-speciwc phospholipase C4 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q2V2X4, Q940R9, Q944C1, Q9LUY9
      UniProtKB/TrEMBL
      A0A178UP87, A0A5S9YF77
      Conserved Domains (1) summary
      PLN02230
      Location:1 → 597
      PLN02230; phosphoinositide phospholipase C 4

    2. NM_125257.3 → NP_200678.2  phosphatidylinositol-speciwc phospholipase C4 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_200678.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q2V2X4, Q940R9, Q944C1, Q9LUY9
      UniProtKB/TrEMBL
      A0A178UP87, A0A5S9YF77
      Conserved Domains (1) summary
      PLN02230
      Location:1 → 597
      PLN02230; phosphoinositide phospholipase C 4

    3. NM_001037020.2 → NP_001032097.1  phosphatidylinositol-speciwc phospholipase C4 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001032097.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A5S9YF77, B9DGG5
      Conserved Domains (2) summary
      cd00275
      Location:359 → 488
      C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
      cd08599
      Location:5 → 328
      PI-PLCc_plant; Catalytic domain of plant phosphatidylinositide-specific phospholipases C
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q944C1.2

    Gene LinkOut

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