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    SKIP2 SKP1/ASK1-interacting protein 2 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 836860, updated on 18-Sep-2024

    Summary

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    Official Symbol
    SKIP2
    Official Full Name
    SKP1/ASK1-interacting protein 2
    Primary source
    TAIR:AT5G67250
    Locus tag
    AT5G67250
    See related
    Araport:AT5G67250
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    K21H1.6; K21H1_6; SKP1/ASK1-interacting protein 2; VFB4; VIER F-BOX PROTEINE 4
    Summary
    Encodes an SKP1 interacting partner (SKIP2).Encodes an F-box protein. Based on genetic analysis appears to be functionally redundant with VFB1,2, and 3. When expression of all 4 genes is reduced plants show defects in growth and reduced expression of auxin response genes.
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    Genomic context

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    See SKIP2 in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    1
    Sequence:
    Chromosome: 5; NC_003076.8 (26831185..26833903, complement)

    Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene Nucleotide-diphospho-sugar transferases superfamily protein Neighboring gene small RNA degrading nuclease 3 Neighboring gene uncharacterized protein Neighboring gene CYCLIN D3;2 Neighboring gene uncharacterized protein Neighboring gene end binding protein 1C

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003076.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Characterization of the VIER F-BOX PROTEINE genes from Arabidopsis reveals their importance for plant growth and development. Schwager KM, et al. Plant Cell, 2007 Apr. PMID 17435085, Free PMC Article
    2. SKP1-SnRK protein kinase interactions mediate proteasomal binding of a plant SCF ubiquitin ligase. Farrás R, et al. EMBO J, 2001 Jun 1. PMID 11387208, Free PMC Article
    3. The F-box subunit of the SCF E3 complex is encoded by a diverse superfamily of genes in Arabidopsis. Gagne JM, et al. Proc Natl Acad Sci U S A, 2002 Aug 20. PMID 12169662, Free PMC Article
    4. 14-3-3 proteins fine-tune plant nutrient metabolism. Shin R, et al. FEBS Lett, 2011 Jan 3. PMID 21094157
    5. Evidence for network evolution in an Arabidopsis interactome map. Arabidopsis Interactome Mapping Consortium. Science, 2011 Jul 29. PMID 21798944, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_126125.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables ubiquitin-protein transferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in protein ubiquitination IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    SKP1/ASK1-interacting protein 2
    NP_569047.1
    • SKP1/ASK1-interacting protein 2 (SKIP2); FUNCTIONS IN: ubiquitin-protein ligase activity; INVOLVED IN: N-terminal protein myristoylation; LOCATED IN: cytoplasm; EXPRESSED IN: 25 plant structures; EXPRESSED DURING: 14 growth stages; CONTAINS InterPro DOMAIN/s: F-box domain, cyclin-like (InterPro:IPR001810), F-box domain, Skp2-like (InterPro:IPR022364); BEST Arabidopsis thaliana protein match is: VIER F-box proteine 2 (TAIR:AT3G50080.1); Has 30201 Blast hits to 17322 proteins in 780 species: Archae - 12; Bacteria - 1396; Metazoa - 17338; Fungi - 3422; Plants - 5037; Viruses - 0; Other Eukaryotes - 2996 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003076.8 Reference assembly

      Range
      26831185..26833903 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_126125.3 → NP_569047.1  SKP1/ASK1-interacting protein 2 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_569047.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q0WWL1, Q940A1, Q9FE83
      UniProtKB/TrEMBL
      A0A178UK44, A0A5S9YIB2, A0A654GEV9, A0A7G2FQA7
      Conserved Domains (3) summary
      cd09293
      Location:311 → 416
      AMN1; Antagonist of mitotic exit network protein 1
      sd00034
      Location:239 → 264
      LRR_AMN1; leucine-rich repeat [structural motif]
      pfam12937
      Location:45 → 73
      F-box-like
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9FE83.1

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