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    CLT1 CRT (chloroquine-resistance transporter)-like transporter 1 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 832058, updated on 18-Sep-2024

    Summary

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    Official Symbol
    CLT1
    Official Full Name
    CRT (chloroquine-resistance transporter)-like transporter 1
    Primary source
    TAIR:AT5G19380
    Locus tag
    AT5G19380
    See related
    Araport:AT5G19380
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    CRT (chloroquine-resistance transporter)-like transporter 1; F7K24.130; F7K24_130
    Summary
    Encodes one of the CRT-Like transporters (CLT1/AT5G19380, CLT2/AT4G24460, CLT3/AT5G12170). Required for glutathione homeostasis and stress responses. Mutants lacking these transporters are heavy metal-sensitive, glutathione(GSH)-deficient, and hypersensitive to Phytophthora infection.
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    Genomic context

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    See CLT1 in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    12
    Sequence:
    Chromosome: 5; NC_003076.8 (6526807..6530713, complement)

    Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene RNA-binding (RRM/RBD/RNP motifs) family protein Neighboring gene calcium-dependent protein kinase 34 Neighboring gene rhodanese-like domain-containing protein / PPIC-type PPIASE domain-containing protein Neighboring gene Rho GTPase activation protein (RhoGAP) with PH domain-containing protein Neighboring gene Telomerase activating protein Est1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003076.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Plant homologs of the Plasmodium falciparum chloroquine-resistance transporter, PfCRT, are required for glutathione homeostasis and stress responses. Maughan SC, et al. Proc Natl Acad Sci U S A, 2010 Feb 2. PMID 20080670, Free PMC Article
    2. Sequence and analysis of chromosome 5 of the plant Arabidopsis thaliana. Tabata S, et al. Nature, 2000 Dec 14. PMID 11130714

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    NM_001161249.1
    NM_121943.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within defense response to oomycetes IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within glutathione transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within response to cadmium ion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in plastid IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    CRT (chloroquine-resistance transporter)-like transporter 1
    NP_001154721.1
    • CRT (chloroquine-resistance transporter)-like transporter 1 (CLT1); BEST Arabidopsis thaliana protein match is: CRT (chloroquine-resistance transporter)-like transporter 3 (TAIR:AT5G12170.2); Has 381 Blast hits to 375 proteins in 143 species: Archae - 0; Bacteria - 190; Metazoa - 0; Fungi - 0; Plants - 90; Viruses - 0; Other Eukaryotes - 101 (source: NCBI BLink).
    NP_568373.1
    • CRT (chloroquine-resistance transporter)-like transporter 1 (CLT1); BEST Arabidopsis thaliana protein match is: CRT (chloroquine-resistance transporter)-like transporter 3 (TAIR:AT5G12170.2); Has 30201 Blast hits to 17322 proteins in 780 species: Archae - 12; Bacteria - 1396; Metazoa - 17338; Fungi - 3422; Plants - 5037; Viruses - 0; Other Eukaryotes - 2996 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003076.8 Reference assembly

      Range
      6526807..6530713 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001161249.1 → NP_001154721.1  CRT (chloroquine-resistance transporter)-like transporter 1 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001154721.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A654G2G2, F4K139, Q8LE71
      Conserved Domains (1) summary
      cl23754
      Location:105 → 488
      EamA; EamA-like transporter family

    2. NM_121943.3 → NP_568373.1  CRT (chloroquine-resistance transporter)-like transporter 1 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_568373.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q058P6
      UniProtKB/TrEMBL
      Q8LE71
      Conserved Domains (1) summary
      cl23754
      Location:105 → 428
      EamA; EamA-like transporter family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q058P6.1

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