KCR1 beta-ketoacyl reductase 1 [Arabidopsis thaliana (thale cress)] - Gene

Summary

Official Symbol: KCR1
Official Full Name: beta-ketoacyl reductase 1
Primary source: TAIR:AT1G67730
Locus tag: AT1G67730
See related: Araport:AT1G67730
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: ATKCR1; beta-ketoacyl reductase 1; F12A21.14; F12A21_14; YBR159
Summary: Encodes one of the two Arabidopsis homologues to YBR159w encoding a S. cerevisiae beta-ketoacyl reductase (KCR), which catalyzes the first reduction during VLCFA (very long chain fatty acids, >18 carbon) elongation: KCR1 (At1g67730), KCR2 (At1g24470). Complementation of the yeast ybr159Delta mutant demonstrated that the two KCR proteins are divergent and that only AtKCR1 can restore heterologous elongase activity similar to the native yeast KCR gene.
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Chromosome 1 - NC_003070.9 Genomic Context describing neighboring genes

Go to nucleotide: Graphics FASTA GenBank

AtKCR1 is a functional beta-ketoacyl-coenzyme A reductase isoform involved in microsomal fatty acid elongation.
Title: Functional characterization of the Arabidopsis beta-ketoacyl-coenzyme A reductase candidates of the fatty acid elongase.

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

NM_105441.3

Function	Evidence Code	Pubs
enables acetoacetyl-CoA reductase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables ketoreductase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables very-long-chain 3-oxoacyl-CoA reductase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within embryo development ending in seed dormancy	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within very long-chain fatty acid biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in chloroplast	ISM Inferred from Sequence Model more info
located_in endoplasmic reticulum	HDA more info	PubMed
located_in endoplasmic reticulum	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrion	HDA more info	PubMed

NP_564905.1

beta-ketoacyl reductase 1 (KCR1); FUNCTIONS IN: oxidoreductase activity, ketoreductase activity, acetoacetyl-CoA reductase activity; INVOLVED IN: very long-chain fatty acid biosynthetic process, embryo development, cuticle development; LOCATED IN: endoplasmic reticulum, membrane; EXPRESSED IN: 26 plant structures; EXPRESSED DURING: 14 growth stages; CONTAINS InterPro DOMAIN/s: Short-chain dehydrogenase/reductase, conserved site (InterPro:IPR020904), NAD(P)-binding domain (InterPro:IPR016040), Glucose/ribitol dehydrogenase (InterPro:IPR002347), Short-chain dehydrogenase/reductase SDR (InterPro:IPR002198); BEST Arabidopsis thaliana protein match is: beta-ketoacyl reductase 2 (TAIR:AT1G24470.1); Has 86831 Blast hits to 86679 proteins in 3373 species: Archae - 739; Bacteria - 59178; Metazoa - 5127; Fungi - 3946; Plants - 2216; Viruses - 0; Other Eukaryotes - 15625 (source: NCBI BLink).