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    ZNF445 zinc finger protein 445 [ Homo sapiens (human) ]

    Gene ID: 353274, updated on 10-Dec-2024

    Summary

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    Official Symbol
    ZNF445provided by HGNC
    Official Full Name
    zinc finger protein 445provided by HGNC
    Primary source
    HGNC:HGNC:21018
    See related
    Ensembl:ENSG00000185219 MIM:619508; AllianceGenome:HGNC:21018
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ZFP445; ZNF168; ZSCAN47; ZKSCAN15
    Summary
    Enables double-stranded methylated DNA binding activity. Involved in epigenetic programing of female pronucleus and negative regulation of gene expression via chromosomal CpG island methylation. Located in nucleus. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in ovary (RPKM 3.6), brain (RPKM 3.4) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See ZNF445 in Genome Data Viewer
    Location:
    3p21.31
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (44431705..44477670, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (44447545..44493482, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (44473197..44519162, complement)

    Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene H3K27ac hESC enhancer GRCh37_chr3:44379271-44379924 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14262 Neighboring gene T cell activation inhibitor, mitochondrial Neighboring gene MPRA-validated peak4626 silencer Neighboring gene ReSE screen-validated silencer GRCh37_chr3:44420112-44420270 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19763 Neighboring gene long intergenic non-protein coding RNA 694 Neighboring gene long intergenic non-protein coding RNA 1988 Neighboring gene ReSE screen-validated silencer GRCh37_chr3:44482886-44483092 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14263 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14264 Neighboring gene uncharacterized LOC101928529 Neighboring gene zinc finger protein 852 Neighboring gene H3K27ac hESC enhancer GRCh37_chr3:44551492-44552268

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Activation of transcriptional activities of AP1 and SRE by a novel zinc finger protein ZNF445. Luo K, et al. Gene, 2006 Feb 15. PMID 16368201
    2. Positional cloning of cDNAs from the human chromosome 3p21-22 region identifies a clustered organization of zinc-finger genes. Calabrò V, et al. Hum Genet, 1995 Jan. PMID 7814019
    3. ZNF445 is a primary regulator of genomic imprinting. Takahashi N, et al. Genes Dev, 2019 Jan 1. PMID 30602440, Free PMC Article
    4. HENA, heterogeneous network-based data set for Alzheimer's disease. Sügis E, et al. Sci Data, 2019 Aug 14. PMID 31413325, Free PMC Article
    5. Acetylation-Mimic Mutation of TRIM28-Lys304 to Gln Attenuates the Interaction with KRAB-Zinc-Finger Proteins and Affects Gene Expression in Leukemic K562 Cells. Chang YJ, et al. Int J Mol Sci, 2023 Jun 6. PMID 37372979, Free PMC Article

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
      Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC126535

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA-binding transcription activator activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables chromatin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables double-stranded methylated DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in epigenetic programing of female pronucleus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of gene expression via chromosomal CpG island methylation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    zinc finger protein 445
    Names
    zinc finger protein 168
    zinc finger protein with KRAB and SCAN domains 15

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001369454.1 → NP_001356383.1  zinc finger protein 445 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC134943, AY295873
      UniProtKB/TrEMBL
      B7ZKX2
      Conserved Domains (4) summary
      smart00431
      Location:51 → 155
      SCAN; leucine rich region
      smart00349
      Location:222 → 280
      KRAB; krueppel associated box
      COG5048
      Location:583 → 1019
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:475 → 495
      ZF_C2H2; C2H2 Zn finger [structural motif]

    2. NM_181489.6 → NP_852466.1  zinc finger protein 445 isoform 1

      See identical proteins and their annotated locations for NP_852466.1

      Status: VALIDATED

      Source sequence(s)
      AC134943, AY295873, BX108541
      Consensus CDS
      CCDS2713.1
      UniProtKB/Swiss-Prot
      P59923, Q3MJD1
      Related
      ENSP00000379387.2, ENST00000396077.8
      Conserved Domains (4) summary
      smart00431
      Location:51 → 155
      SCAN; leucine rich region
      smart00349
      Location:234 → 292
      KRAB; krueppel associated box
      COG5048
      Location:595 → 1031
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:487 → 507
      ZF_C2H2; C2H2 Zn finger [structural motif]

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

      Range
      44431705..44477670 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060927.1 Alternate T2T-CHM13v2.0

      Range
      44447545..44493482 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P59923.1 GenPept UniProtKB/Swiss-Prot:P59923

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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