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    LINC02912 long intergenic non-protein coding RNA 2912 [ Homo sapiens (human) ]

    Gene ID: 641384, updated on 10-Dec-2024

    Summary

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    Official Symbol
    LINC02912provided by HGNC
    Official Full Name
    long intergenic non-protein coding RNA 2912provided by HGNC
    Primary source
    HGNC:HGNC:32295
    See related
    Ensembl:ENSG00000280055 AllianceGenome:HGNC:32295
    Gene type
    ncRNA
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    TMEM75
    Summary
    Predicted to be located in membrane. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See LINC02912 in Genome Data Viewer
    Location:
    8q24.21
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 8 NC_000008.11 (127946559..127948723, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 8 NC_060932.1 (129074414..129076578, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (128958805..128960969, complement)

    Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene NANOG hESC enhancer GRCh37_chr8:128744882-128745383 Neighboring gene origin of replication upstream of MYC Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19530 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr8:128754894-128756093 Neighboring gene MYC proto-oncogene, bHLH transcription factor Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:128805180-128805750 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19531 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19532 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19533 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:128806893-128807462 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:128807463-128808034 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19534 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:128814781-128815422 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:128815423-128816064 Neighboring gene H3K27ac hESC enhancer GRCh37_chr8:128816065-128816704 Neighboring gene Sharpr-MPRA regulatory region 14038 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:128821670-128822570 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:128822571-128823470 Neighboring gene Sharpr-MPRA regulatory region 15510 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:128830247-128830786 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:128832947-128833486 Neighboring gene microRNA 1204 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr8:128834567-128835106 Neighboring gene Pvt1 oncogene Neighboring gene ReSE screen-validated silencer GRCh37_chr8:128858753-128858938 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:128862019-128862636 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:128864303-128865152 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr8:128866418-128867617 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:128879341-128879948 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:128888845-128889392 Neighboring gene ReSE screen-validated silencer GRCh37_chr8:128891961-128892128 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:128893083-128893582 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27949 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27950 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27951 Neighboring gene Sharpr-MPRA regulatory region 1737 Neighboring gene CRISPRi-validated MYC e1 enhancer Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:128913423-128914077 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:128916503-128917004 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:128920055-128920986 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:128920987-128921919 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr8:128923753-128924342 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27953 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:128932048-128932575 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:128936915-128937414 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:128951647-128952169 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:128969595-128970406 Neighboring gene CRISPRi-validated MYC e2 enhancer Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:128976545-128977156 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19535 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27954 Neighboring gene microRNA 1205 Neighboring gene H3K27ac hESC enhancer GRCh37_chr8:129004541-129005042 Neighboring gene H3K27ac hESC enhancer GRCh37_chr8:129005043-129005542 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27956 Neighboring gene RNA, variant U1 small nuclear 32

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Long noncoding RNA TMEM75 promotes colorectal cancer progression by activation of SIM2. Jin X, et al. Gene, 2018 Oct 30. PMID 29964097
    2. Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility. DIAbetes Genetics Replication And Meta-analysis (DIAGRAM) Consortium, et al. Nat Genet, 2014 Mar. PMID 24509480, Free PMC Article
    3. Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population. Comuzzie AG, et al. PLoS One, 2012. PMID 23251661, Free PMC Article
    4. VIRMA mediates preferential m(6)A mRNA methylation in 3'UTR and near stop codon and associates with alternative polyadenylation. Yue Y, et al. Cell Discov, 2018. PMID 29507755, Free PMC Article
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. Ota T, et al. Nat Genet, 2004 Jan. PMID 14702039

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. TMEM75 functions as an oncogene relying on activation of SIM2 in colorectal cancer.
      Title: Long noncoding RNA TMEM75 promotes colorectal cancer progression by activation of SIM2.
    Submit: New GeneRIF Correction

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility.
    EBI GWAS Catalog
    Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Other Names

    • transmembrane protein 75

    Clone Names

    • FLJ36105

    Gene Ontology Provided by GOA

    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    RNA

    1. NR_103558.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC103705, AK093424
      Related
      ENST00000624314.1

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000008.11 Reference GRCh38.p14 Primary Assembly

      Range
      127946559..127948723 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060932.1 Alternate T2T-CHM13v2.0

      Range
      129074414..129076578 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001037234.1: Suppressed sequence

      Description
      NM_001037234.1: This RefSeq was permanently suppressed because currently there is support for the transcript but not for the protein.
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8N9X5.1 GenPept UniProtKB/Swiss-Prot:Q8N9X5

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials