U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    TPST1 tyrosylprotein sulfotransferase 1 [ Homo sapiens (human) ]

    Gene ID: 8460, updated on 3-Dec-2024

    Summary

    Official Symbol
    TPST1provided by HGNC
    Official Full Name
    tyrosylprotein sulfotransferase 1provided by HGNC
    Primary source
    HGNC:HGNC:12020
    See related
    Ensembl:ENSG00000169902 MIM:603125; AllianceGenome:HGNC:12020
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    TANGO13A
    Summary
    Enables protein homodimerization activity and protein-tyrosine sulfotransferase activity. Involved in post-translational protein modification. Located in Golgi membrane. Implicated in colorectal adenocarcinoma. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in gall bladder (RPKM 13.2), urinary bladder (RPKM 9.5) and 22 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See TPST1 in Genome Data Viewer
    Location:
    7q11.21
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (66198790..66360443)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (67420877..67582531)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (65670321..65825430)

    Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18203 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26080 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:65551291-65551918 Neighboring gene H3K27ac hESC enhancer GRCh37_chr7:65565192-65565753 Neighboring gene ReSE screen-validated silencer GRCh37_chr7:65578710-65578900 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26081 Neighboring gene H3K27ac hESC enhancer GRCh37_chr7:65580214-65580742 Neighboring gene argininosuccinate lyase Neighboring gene MED14-independent group 3 enhancer GRCh37_chr7:65612993-65614192 Neighboring gene CGRP receptor component Neighboring gene ReSE screen-validated silencer GRCh37_chr7:65642926-65643089 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18204 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18205 Neighboring gene MPRA-validated peak6545 silencer Neighboring gene NANOG hESC enhancer GRCh37_chr7:65779787-65780442 Neighboring gene H3K27ac hESC enhancer GRCh37_chr7:65814565-65815064 Neighboring gene RNA, U6 small nuclear 313, pseudogene Neighboring gene ReSE screen-validated silencer GRCh37_chr7:65827447-65827611 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:65853152-65853652 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:65853653-65854153 Neighboring gene long intergenic non-protein coding RNA 174 Neighboring gene uncharacterized LOC124901822 Neighboring gene general transcription factor IIi pseudogene 9

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env The chemokine receptor CCR5 is posttranslationally modified by sulfation of its N-terminal tyrosines; sulfated tyrosines contribute to the binding of CCR5 to MIP-1 alpha, MIP-1 beta, and HIV-1 gp120/CD4 complexes and to the ability of HIV-1 to enter cells PubMed

    Go to the HIV-1, Human Interaction Database

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein homodimerization activity IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein-tyrosine sulfotransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein-tyrosine sulfotransferase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein-tyrosine sulfotransferase activity TAS
    Traceable Author Statement
    more info
     
    Component Evidence Code Pubs
    is_active_in Golgi apparatus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in Golgi membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in Golgi membrane TAS
    Traceable Author Statement
    more info
     
    located_in membrane TAS
    Traceable Author Statement
    more info
    PubMed 

    General protein information

    Preferred Names
    protein-tyrosine sulfotransferase 1
    Names
    TPST-1
    transport and golgi organization 13 homolog A
    NP_003587.1
    XP_005250699.1
    XP_011514936.1
    XP_011514937.1
    XP_016868215.1
    XP_016868216.1
    XP_047276912.1
    XP_047276913.1
    XP_047276914.1
    XP_047276915.1
    XP_047276916.1
    XP_047276918.1
    XP_047276919.1
    XP_054215199.1
    XP_054215200.1
    XP_054215201.1
    XP_054215202.1
    XP_054215203.1
    XP_054215204.1
    XP_054215205.1
    XP_054215206.1
    XP_054215207.1
    XP_054215208.1
    XP_054215209.1
    XP_054215210.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_003596.4NP_003587.1  protein-tyrosine sulfotransferase 1

      See identical proteins and their annotated locations for NP_003587.1

      Status: VALIDATED

      Source sequence(s)
      BC013188
      Consensus CDS
      CCDS5533.1
      UniProtKB/Swiss-Prot
      A4D2M0, O60507, Q6FGM7
      UniProtKB/TrEMBL
      Q75M96
      Related
      ENSP00000302413.5, ENST00000304842.6
      Conserved Domains (1) summary
      pfam13469
      Location:72261
      Sulfotransfer_3; Sulfotransferase family

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

      Range
      66198790..66360443
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047420959.1XP_047276915.1  protein-tyrosine sulfotransferase 1 isoform X2

      UniProtKB/Swiss-Prot
      A4D2M0, O60507, Q6FGM7
      UniProtKB/TrEMBL
      Q75M96
    2. XM_047420957.1XP_047276913.1  protein-tyrosine sulfotransferase 1 isoform X1

      UniProtKB/TrEMBL
      Q75M96
    3. XM_047420960.1XP_047276916.1  protein-tyrosine sulfotransferase 1 isoform X2

      UniProtKB/Swiss-Prot
      A4D2M0, O60507, Q6FGM7
      UniProtKB/TrEMBL
      Q75M96
    4. XM_047420962.1XP_047276918.1  protein-tyrosine sulfotransferase 1 isoform X2

      UniProtKB/Swiss-Prot
      A4D2M0, O60507, Q6FGM7
      UniProtKB/TrEMBL
      Q75M96
    5. XM_047420958.1XP_047276914.1  protein-tyrosine sulfotransferase 1 isoform X2

      UniProtKB/Swiss-Prot
      A4D2M0, O60507, Q6FGM7
      UniProtKB/TrEMBL
      Q75M96
    6. XM_017012726.3XP_016868215.1  protein-tyrosine sulfotransferase 1 isoform X2

      UniProtKB/Swiss-Prot
      A4D2M0, O60507, Q6FGM7
      UniProtKB/TrEMBL
      Q75M96
      Conserved Domains (1) summary
      pfam13469
      Location:72261
      Sulfotransfer_3; Sulfotransferase family
    7. XM_017012727.3XP_016868216.1  protein-tyrosine sulfotransferase 1 isoform X2

      UniProtKB/Swiss-Prot
      A4D2M0, O60507, Q6FGM7
      UniProtKB/TrEMBL
      Q75M96
      Conserved Domains (1) summary
      pfam13469
      Location:72261
      Sulfotransfer_3; Sulfotransferase family
    8. XM_011516635.4XP_011514937.1  protein-tyrosine sulfotransferase 1 isoform X3

      See identical proteins and their annotated locations for XP_011514937.1

      UniProtKB/TrEMBL
      Q75M96
      Conserved Domains (1) summary
      pfam13469
      Location:72261
      Sulfotransfer_3; Sulfotransferase family
    9. XM_047420963.1XP_047276919.1  protein-tyrosine sulfotransferase 1 isoform X3

      UniProtKB/TrEMBL
      Q75M96
    10. XM_011516634.4XP_011514936.1  protein-tyrosine sulfotransferase 1 isoform X3

      See identical proteins and their annotated locations for XP_011514936.1

      UniProtKB/TrEMBL
      Q75M96
      Conserved Domains (1) summary
      pfam13469
      Location:72261
      Sulfotransfer_3; Sulfotransferase family
    11. XM_005250642.4XP_005250699.1  protein-tyrosine sulfotransferase 1 isoform X1

      See identical proteins and their annotated locations for XP_005250699.1

      UniProtKB/TrEMBL
      Q75M96
      Conserved Domains (1) summary
      pfam13469
      Location:69257
      Sulfotransfer_3; Sulfotransferase family
    12. XM_047420956.1XP_047276912.1  protein-tyrosine sulfotransferase 1 isoform X1

      UniProtKB/TrEMBL
      Q75M96

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060931.1 Alternate T2T-CHM13v2.0

      Range
      67420877..67582531
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054359230.1XP_054215205.1  protein-tyrosine sulfotransferase 1 isoform X2

      UniProtKB/Swiss-Prot
      A4D2M0, O60507, Q6FGM7
      UniProtKB/TrEMBL
      Q75M96
    2. XM_054359226.1XP_054215201.1  protein-tyrosine sulfotransferase 1 isoform X1

      UniProtKB/TrEMBL
      Q75M96
    3. XM_054359231.1XP_054215206.1  protein-tyrosine sulfotransferase 1 isoform X2

      UniProtKB/Swiss-Prot
      A4D2M0, O60507, Q6FGM7
      UniProtKB/TrEMBL
      Q75M96
    4. XM_054359232.1XP_054215207.1  protein-tyrosine sulfotransferase 1 isoform X2

      UniProtKB/Swiss-Prot
      A4D2M0, O60507, Q6FGM7
      UniProtKB/TrEMBL
      Q75M96
    5. XM_054359227.1XP_054215202.1  protein-tyrosine sulfotransferase 1 isoform X2

      UniProtKB/Swiss-Prot
      A4D2M0, O60507, Q6FGM7
      UniProtKB/TrEMBL
      Q75M96
    6. XM_054359228.1XP_054215203.1  protein-tyrosine sulfotransferase 1 isoform X2

      UniProtKB/Swiss-Prot
      A4D2M0, O60507, Q6FGM7
      UniProtKB/TrEMBL
      Q75M96
    7. XM_054359229.1XP_054215204.1  protein-tyrosine sulfotransferase 1 isoform X2

      UniProtKB/Swiss-Prot
      A4D2M0, O60507, Q6FGM7
      UniProtKB/TrEMBL
      Q75M96
    8. XM_054359234.1XP_054215209.1  protein-tyrosine sulfotransferase 1 isoform X3

      UniProtKB/TrEMBL
      Q75M96
    9. XM_054359235.1XP_054215210.1  protein-tyrosine sulfotransferase 1 isoform X3

      UniProtKB/TrEMBL
      Q75M96
    10. XM_054359233.1XP_054215208.1  protein-tyrosine sulfotransferase 1 isoform X3

      UniProtKB/TrEMBL
      Q75M96
    11. XM_054359224.1XP_054215199.1  protein-tyrosine sulfotransferase 1 isoform X1

      UniProtKB/TrEMBL
      Q75M96
    12. XM_054359225.1XP_054215200.1  protein-tyrosine sulfotransferase 1 isoform X1

      UniProtKB/TrEMBL
      Q75M96