Pm20d2 peptidase M20 domain containing 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Pm20d2provided by RGD
Official Full Name: peptidase M20 domain containing 2provided by RGD
Primary source: RGD:1307853
See related: EnsemblRapid:ENSRNOG00000007755 AllianceGenome:RGD:1307853
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Acy1l2
Summary: Enables dipeptidase activity. Acts upstream of or within proteolysis. Predicted to be located in nucleoplasm. Orthologous to human PM20D2 (peptidase M20 domain containing 2). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Muscle (RPKM 237.1), Kidney (RPKM 139.9) and 8 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 5q21

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	5	NC_086023.1 (52362384..52382647, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	5	NC_051340.1 (47566059..47586334, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	5	NC_005104.4 (48416005..48437054, complement)

Chromosome 5 - NC_086023.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

PM20D2 hydrolyzed beta-alanyl-lysine, beta-alanyl-ornithine, gamma-aminobutyryl-lysine, and gamma-aminobutyryl-ornithine as its best substrates.
Title: Metabolite proofreading in carnosine and homocarnosine synthesis: molecular identification of PM20D2 as β-alanyl-lysine dipeptidase.

Submit: New GeneRIF Correction

General gene information

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Markers

RH142708 (e-PCR)
- UniSTS:231955

AU026247 (e-PCR)
- UniSTS:114468

RH141311 (e-PCR)
- UniSTS:223307

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables carboxypeptidase activity	IEA Inferred from Electronic Annotation more info
enables dipeptidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables dipeptidase activity	IDA Inferred from Direct Assay more info	PubMed
enables dipeptidase activity	ISO Inferred from Sequence Orthology more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
NOT enables para-aminobenzoyl-glutamate hydrolase activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
NOT involved_in folic acid catabolic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within proteolysis	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within proteolysis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of protein metabolic process	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
NOT is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: xaa-Arg dipeptidase

Names: aminoacylase 1-like 2; peptidase M20 domain-containing protein 2

NP_001101392.2

EC 3.4.13.4

XP_063143655.1

EC 3.4.13.4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.