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    Adamts6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 361886, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Adamts6provided by RGD
    Official Full Name
    ADAM metallopeptidase with thrombospondin type 1 motif, 6provided by RGD
    Primary source
    RGD:1307678
    See related
    EnsemblRapid:ENSRNOG00000012655 AllianceGenome:RGD:1307678
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable metalloendopeptidase activity. Predicted to be involved in extracellular matrix organization and proteolysis. Predicted to act upstream of or within circulatory system development and kidney development. Predicted to be located in extracellular region. Predicted to be active in extracellular matrix. Orthologous to human ADAMTS6 (ADAM metallopeptidase with thrombospondin type 1 motif 6). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Heart (RPKM 34.0), Lung (RPKM 31.8) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Adamts6 in Genome Data Viewer
    Location:
    2q13
    Exon count:
    29
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (37155260..37367077)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (35421483..35633305)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (34374142..34589676)

    Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene tripartite motif-containing 23 Neighboring gene peptidylprolyl isomerase domain and WD repeat containing 1 Neighboring gene centromere protein K Neighboring gene large ribosomal subunit protein eL21-like Neighboring gene U6 spliceosomal RNA Neighboring gene uncharacterized protein C11orf98 homolog Neighboring gene ribosomal protein S29, pseudogene 14 Neighboring gene CWC27 spliceosome associated cyclophilin

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. FMRP recruitment of β-catenin to the translation pre-initiation complex represses translation. Ehyai S, et al. EMBO Rep, 2018 Dec. PMID 30361391, Free PMC Article
    2. Global genetic analysis in mice unveils central role for cilia in congenital heart disease. Li Y, et al. Nature, 2015 May 28. PMID 25807483, Free PMC Article
    3. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metalloendopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within aorta development ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within cardiac septum development ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within coronary vasculature development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in extracellular matrix organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within heart development ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within kidney development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in proteolysis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in extracellular matrix IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    A disintegrin and metalloproteinase with thrombospondin motifs 6
    Names
    a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 6
    a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 6

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001108544.2 → NP_001102014.2  A disintegrin and metalloproteinase with thrombospondin motifs 6 precursor

      Status: VALIDATED

      Source sequence(s)
      CN542748, JAXUCZ010000002
      UniProtKB/TrEMBL
      D4A065
      Related
      ENSRNOP00000016997.4, ENSRNOT00000016997.9
      Conserved Domains (7) summary
      smart00209
      Location:561 → 613
      TSP1; Thrombospondin type 1 repeats
      cd04273
      Location:250 → 465
      ZnMc_ADAMTS_like; Zinc-dependent metalloprotease, ADAMTS_like subgroup. ADAMs (A Disintegrin And Metalloprotease) are glycoproteins, which play roles in cell signaling, cell fusion, and cell-cell interactions. This particular subfamily represents domain architectures that ...
      pfam05986
      Location:719 → 829
      ADAM_spacer1; ADAM-TS Spacer 1
      pfam01562
      Location:43 → 191
      Pep_M12B_propep; Reprolysin family propeptide
      pfam08686
      Location:1083 → 1115
      PLAC; PLAC (protease and lacunin) domain
      pfam17771
      Location:480 → 548
      ADAM_CR_2; ADAM cysteine-rich domain
      pfam19030
      Location:903 → 959
      TSP1_ADAMTS; Thrombospondin type 1 domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086020.1 Reference GRCr8

      Range
      37155260..37367077
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039102547.2 → XP_038958475.1  A disintegrin and metalloproteinase with thrombospondin motifs 6 isoform X1

      Conserved Domains (5) summary
      smart00209
      Location:561 → 613
      TSP1; Thrombospondin type 1 repeats
      cd04273
      Location:250 → 465
      ZnMc_ADAMTS_like; Zinc-dependent metalloprotease, ADAMTS_like subgroup. ADAMs (A Disintegrin And Metalloprotease) are glycoproteins, which play roles in cell signaling, cell fusion, and cell-cell interactions. This particular subfamily represents domain architectures that ...
      pfam05986
      Location:719 → 829
      ADAM_spacer1; ADAM-TS Spacer 1
      pfam01562
      Location:43 → 191
      Pep_M12B_propep; Reprolysin family propeptide
      pfam17771
      Location:480 → 548
      ADAM_CR_2; ADAM cysteine-rich domain

    2. XM_039102548.2 → XP_038958476.1  A disintegrin and metalloproteinase with thrombospondin motifs 6 isoform X2

      Conserved Domains (5) summary
      smart00209
      Location:561 → 613
      TSP1; Thrombospondin type 1 repeats
      cd04273
      Location:250 → 465
      ZnMc_ADAMTS_like; Zinc-dependent metalloprotease, ADAMTS_like subgroup. ADAMs (A Disintegrin And Metalloprotease) are glycoproteins, which play roles in cell signaling, cell fusion, and cell-cell interactions. This particular subfamily represents domain architectures that ...
      pfam05986
      Location:719 → 829
      ADAM_spacer1; ADAM-TS Spacer 1
      pfam01562
      Location:43 → 191
      Pep_M12B_propep; Reprolysin family propeptide
      pfam17771
      Location:480 → 548
      ADAM_CR_2; ADAM cysteine-rich domain

    3. XM_039102553.2 → XP_038958481.1  A disintegrin and metalloproteinase with thrombospondin motifs 6 isoform X9

      Conserved Domains (4) summary
      smart00209
      Location:561 → 611
      TSP1; Thrombospondin type 1 repeats
      cd04273
      Location:250 → 465
      ZnMc_ADAMTS_like; Zinc-dependent metalloprotease, ADAMTS_like subgroup. ADAMs (A Disintegrin And Metalloprotease) are glycoproteins, which play roles in cell signaling, cell fusion, and cell-cell interactions. This particular subfamily represents domain architectures that ...
      pfam01562
      Location:43 → 191
      Pep_M12B_propep; Reprolysin family propeptide
      pfam17771
      Location:480 → 548
      ADAM_CR_2; ADAM cysteine-rich domain

    4. XM_039102549.2 → XP_038958477.1  A disintegrin and metalloproteinase with thrombospondin motifs 6 isoform X3

      Conserved Domains (6) summary
      smart00209
      Location:254 → 306
      TSP1; Thrombospondin type 1 repeats
      pfam05986
      Location:412 → 522
      ADAM_spacer1; ADAM-TS Spacer 1
      pfam08686
      Location:776 → 808
      PLAC; PLAC (protease and lacunin) domain
      pfam17771
      Location:173 → 241
      ADAM_CR_2; ADAM cysteine-rich domain
      pfam19030
      Location:537 → 592
      TSP1_ADAMTS; Thrombospondin type 1 domain
      cl00064
      Location:62 → 158
      ZnMc; Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which ...

    5. XM_039102551.2 → XP_038958479.1  A disintegrin and metalloproteinase with thrombospondin motifs 6 isoform X4

      Conserved Domains (6) summary
      smart00209
      Location:212 → 264
      TSP1; Thrombospondin type 1 repeats
      pfam05986
      Location:370 → 480
      ADAM_spacer1; ADAM-TS Spacer 1
      pfam08686
      Location:734 → 766
      PLAC; PLAC (protease and lacunin) domain
      pfam17771
      Location:131 → 199
      ADAM_CR_2; ADAM cysteine-rich domain
      pfam19030
      Location:495 → 550
      TSP1_ADAMTS; Thrombospondin type 1 domain
      cl00064
      Location:20 → 116
      ZnMc; Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which ...

    6. XM_017591186.3 → XP_017446675.1  A disintegrin and metalloproteinase with thrombospondin motifs 6 isoform X5

    7. XM_039102550.2 → XP_038958478.1  A disintegrin and metalloproteinase with thrombospondin motifs 6 isoform X3

      Conserved Domains (6) summary
      smart00209
      Location:254 → 306
      TSP1; Thrombospondin type 1 repeats
      pfam05986
      Location:412 → 522
      ADAM_spacer1; ADAM-TS Spacer 1
      pfam08686
      Location:776 → 808
      PLAC; PLAC (protease and lacunin) domain
      pfam17771
      Location:173 → 241
      ADAM_CR_2; ADAM cysteine-rich domain
      pfam19030
      Location:537 → 592
      TSP1_ADAMTS; Thrombospondin type 1 domain
      cl00064
      Location:62 → 158
      ZnMc; Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which ...

    8. XM_063282029.1 → XP_063138099.1  A disintegrin and metalloproteinase with thrombospondin motifs 6 isoform X6

    9. XM_017591187.2 → XP_017446676.1  A disintegrin and metalloproteinase with thrombospondin motifs 6 isoform X7

    10. XM_039102552.1 → XP_038958480.1  A disintegrin and metalloproteinase with thrombospondin motifs 6 isoform X8

      Conserved Domains (5) summary
      smart00209
      Location:60 → 112
      TSP1; Thrombospondin type 1 repeats
      pfam05986
      Location:218 → 328
      ADAM_spacer1; ADAM-TS Spacer 1
      pfam08686
      Location:582 → 614
      PLAC; PLAC (protease and lacunin) domain
      pfam17771
      Location:5 → 47
      ADAM_CR_2; ADAM cysteine-rich domain
      pfam19030
      Location:343 → 398
      TSP1_ADAMTS; Thrombospondin type 1 domain

    11. XM_017591188.2 → XP_017446677.1  A disintegrin and metalloproteinase with thrombospondin motifs 6 isoform X8

      Conserved Domains (5) summary
      smart00209
      Location:60 → 112
      TSP1; Thrombospondin type 1 repeats
      pfam05986
      Location:218 → 328
      ADAM_spacer1; ADAM-TS Spacer 1
      pfam08686
      Location:582 → 614
      PLAC; PLAC (protease and lacunin) domain
      pfam17771
      Location:5 → 47
      ADAM_CR_2; ADAM cysteine-rich domain
      pfam19030
      Location:343 → 398
      TSP1_ADAMTS; Thrombospondin type 1 domain

    RNA

    1. XR_005500311.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

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