Atp13a5 ATPase 13A5 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Atp13a5provided by RGD
Official Full Name: ATPase 13A5provided by RGD
Primary source: RGD:1306792
See related: EnsemblRapid:ENSRNOG00000024127 AllianceGenome:RGD:1306792
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: RGD1306792
Summary: Predicted to enable ATPase-coupled monoatomic cation transmembrane transporter activity and polyamine transmembrane transporter activity. Predicted to be involved in intracellular calcium ion homeostasis and polyamine transmembrane transport. Predicted to be active in late endosome membrane. Orthologous to human ATP13A5 (ATPase 13A5). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Brain (RPKM 35.4), Muscle (RPKM 2.8) and 1 other tissue See more
Orthologs: human mouse all
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Genomic context

Location:: 11q22

Exon count:: 30

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	11	NC_086029.1 (84881196..85020597)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	11	NC_051346.1 (71376388..71515789)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	11	NC_005110.4 (74984538..75124249)

Chromosome 11 - NC_086029.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP hydrolysis activity	IEA Inferred from Electronic Annotation more info
enables ATP-dependent H2AZ histone chaperone activity	IEA Inferred from Electronic Annotation more info
enables ATP-dependent H3-H4 histone complex chaperone activity	IEA Inferred from Electronic Annotation more info
enables ATPase-coupled monoatomic cation transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables DNA clamp loader activity	IEA Inferred from Electronic Annotation more info
enables P-type ion transporter activity	IEA Inferred from Electronic Annotation more info
enables P-type transmembrane transporter activity	IEA Inferred from Electronic Annotation more info
enables chromatin extrusion motor activity	IEA Inferred from Electronic Annotation more info
enables cohesin loader activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables polyamine transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in chromatin looping	IEA Inferred from Electronic Annotation more info
involved_in chromatin remodeling	IEA Inferred from Electronic Annotation more info
involved_in intracellular calcium ion homeostasis	IBA Inferred from Biological aspect of Ancestor more info
involved_in monoatomic cation transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in polyamine transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in late endosome membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: probable cation-transporting ATPase 13A5

Names: ATPase type 13A5

NP_001178586.1

EC 3.6.3.-

XP_038944228.1

EC 3.6.3.-

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001191657.1 → NP_001178586.1 probable cation-transporting ATPase 13A5

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000011

UniProtKB/TrEMBL

A6JRW3

Related

ENSRNOP00000086336.1, ENSRNOT00000103101.2

Conserved Domains (6) summary

COG4087
Location:820 → 869

COG4087; Soluble P-type ATPase [General function prediction only]

TIGR01657
Location:24 → 1118

P-ATPase-V; P-type ATPase of unknown pump specificity (type V)

pfam00122
Location:228 → 471

E1-E2_ATPase; E1-E2 ATPase

pfam00690
Location:170 → 239

Cation_ATPase_N; Cation transporter/ATPase, N-terminus

pfam12409
Location:23 → 137

P5-ATPase; P5-type ATPase cation transporter

pfam13246
Location:594 → 637

Cation_ATPase; Cation transport ATPase (P-type)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086029.1 Reference GRCr8

Range

84881196..85020597

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039088300.2 → XP_038944228.1 probable cation-transporting ATPase 13A5 isoform X1

UniProtKB/TrEMBL

A6JRW3, F1MA70

Related

ENSRNOP00000036765.6, ENSRNOT00000035049.7

Conserved Domains (2) summary

cd07542
Location:174 → 1020

P-type_ATPase_cation; P-type cation-transporting ATPases, similar to human ATPase type 13A2 (ATP13A2) protein and Saccharomyces cerevisiae Ypk9p

pfam12409
Location:23 → 142

P5-ATPase; P5-type ATPase cation transporter