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    Spint2 serine peptidase inhibitor, Kunitz type, 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 292770, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Spint2provided by RGD
    Official Full Name
    serine peptidase inhibitor, Kunitz type, 2provided by RGD
    Primary source
    RGD:735123
    See related
    EnsemblRapid:ENSRNOG00000020636 AllianceGenome:RGD:735123
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Pb; HAI-2
    Summary
    Predicted to enable serine-type endopeptidase inhibitor activity. Involved in cellular response to BMP stimulus and negative regulation of neural precursor cell proliferation. Predicted to be located in cytoplasm. Human ortholog(s) of this gene implicated in congenital secretory sodium diarrhea 3. Orthologous to human SPINT2 (serine peptidase inhibitor, Kunitz type 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Kidney (RPKM 1506.7), Lung (RPKM 690.5) and 8 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Spint2 in Genome Data Viewer
    Location:
    1q21
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (93685637..93708091, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (84558159..84580616, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (87199373..87221826, complement)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene MARCKS-related protein-like Neighboring gene similar to human chromosome 19 open reading frame 33 Neighboring gene potassium two pore domain channel subfamily K member 6 Neighboring gene Yip1 interacting factor homolog B, membrane trafficking protein Neighboring gene protein phosphatase 1, regulatory (inhibitor) subunit 14A Neighboring gene double PHD fingers 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Mutations in SPINT2 cause a syndromic form of congenital sodium diarrhea. Heinz-Erian P, et al. Am J Hum Genet, 2009 Feb. PMID 19185281, Free PMC Article
    2. Identification of hepatocyte growth factor activator inhibitor type 2 (HAI-2)-related small peptide (H2RSP): its nuclear localization and generation of chimeric mRNA transcribed from both HAI-2 and H2RSP genes. Itoh H, et al. Biochem Biophys Res Commun, 2001 Oct 26. PMID 11606055
    3. Hepatocyte growth factor activator inhibitor-1 is induced by bone morphogenetic proteins and regulates proliferation and cell fate of neural progenitor cells. Koivuniemi R, et al. PLoS One, 2013. PMID 23409135, Free PMC Article
    4. Persistent elevation of hepatocyte growth factor activator inhibitors in cholangiopathies affects liver fibrosis and differentiation. Huang HP, et al. Hepatology, 2012 Jan. PMID 21898507
    5. Regulation of cell surface protease matriptase by HAI2 is essential for placental development, neural tube closure and embryonic survival in mice. Szabo R, et al. Development, 2009 Aug. PMID 19592578, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC72638

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables serine-type endopeptidase inhibitor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables serine-type endopeptidase inhibitor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within basement membrane organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cellular response to BMP stimulus IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    acts_upstream_of_or_within epithelial cell morphogenesis involved in placental branching ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within establishment or maintenance of cell polarity ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within negative regulation of cell motility ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within negative regulation of cell-cell adhesion ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of neural precursor cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within neural tube closure ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    kunitz-type protease inhibitor 2
    Names
    hepatocyte growth factor activator inhibitor type 2
    placental bikunin
    serine protease inhibitor, Kunitz type 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001082549.1 → NP_001076018.1  kunitz-type protease inhibitor 2 isoform a precursor

      See identical proteins and their annotated locations for NP_001076018.1

      Status: VALIDATED

      Source sequence(s)
      BC061768, DN934634
      UniProtKB/TrEMBL
      A6J9Q4, F6QKA3, G3V8S0
      Related
      ENSRNOP00000043981.3, ENSRNOT00000046611.6
      Conserved Domains (1) summary
      pfam00014
      Location:38 → 88
      Kunitz_BPTI; Kunitz/Bovine pancreatic trypsin inhibitor domain

    2. NM_199087.1 → NP_954518.1  kunitz-type protease inhibitor 2 isoform b precursor

      See identical proteins and their annotated locations for NP_954518.1

      Status: VALIDATED

      Source sequence(s)
      BC061768
      UniProtKB/TrEMBL
      Q6P796
      Conserved Domains (1) summary
      pfam00014
      Location:73 → 124
      Kunitz_BPTI; Kunitz/Bovine pancreatic trypsin inhibitor domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      93685637..93708091 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063283557.1 → XP_063139627.1  kunitz-type protease inhibitor 2 isoform X1

    Nucleotide Protein Strain
    Heading Accession and Version

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