Mycs myc-like oncogene, s-myc protein [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Mycsprovided by RGD
Official Full Name: myc-like oncogene, s-myc proteinprovided by RGD
Primary source: RGD:3133
See related: EnsemblRapid:ENSRNOG00000003085 AllianceGenome:RGD:3133
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Human ortholog(s) of this gene implicated in Feingold syndrome. Orthologous to human MYCN (MYCN proto-oncogene, bHLH transcription factor). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

Location:: Xq12

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	X	NC_086039.1 (19745887..19747179)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	X	NC_051356.1 (17038263..17039555)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	X	NC_005120.4 (17823554..17824846)

Chromosome X - NC_086039.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

genes are idenetified that are regulated by Myc genes
Title: Identifying genes regulated in a Myc-dependent manner.

Submit: New GeneRIF Correction

General gene information

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Markers

dxmit2 (e-PCR)
- UniSTS:120589

DXMit2 (e-PCR)
- UniSTS:119286

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein dimerization activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: protein S-Myc

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_021837.2 → NP_068609.2 protein S-Myc

Status: VALIDATED

Source sequence(s)

JAXUCZ010000021

UniProtKB/Swiss-Prot

P23999

UniProtKB/TrEMBL

A6KPC7, G3V6D6

Related

ENSRNOP00000004118.1, ENSRNOT00000004118.4

Conserved Domains (2) summary

cd11456
Location:344 → 430

bHLHzip_N-Myc_like; basic Helix-Loop-Helix-zipper (bHLHzip) domain found in N-Myc and similar proteins

pfam01056
Location:10 → 331

Myc_N; Myc amino-terminal region