Maf MAF bZIP transcription factor [Rattus norvegicus (Norway rat)] - Gene

Summary

Symbol: Mafprovided by RGD
Full Name: MAF bZIP transcription factorprovided by RGD
Primary source: RGD:3034
See related: EnsemblRapid:ENSRNOG00000012428 AllianceGenome:RGD:3034
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Maf2; cMaf
Summary: Enables DNA-binding transcription factor activity, RNA polymerase II-specific; double-stranded DNA binding activity; and identical protein binding activity. Involved in positive regulation of transcription by RNA polymerase II. Predicted to be located in cytoplasm. Predicted to be part of RNA polymerase II transcription regulator complex. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in Ayme-Gripp syndrome; cataract; and cataract 21 multiple types. Orthologous to human MAF (MAF bZIP transcription factor). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Kidney (RPKM 250.2), Muscle (RPKM 110.1) and 8 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 19q12

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	19	NC_086037.1 (60259200..60622145, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	19	NC_051354.1 (43353867..43713162, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	19	NC_005118.4 (48179826..48200995, complement)

Chromosome 19 - NC_086037.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

a crucial role of the transcription factor Maf in myelination and cholesterol biosynthesis and show that Maf acts downstream from Neuregulin1
Title: Maf links Neuregulin1 signaling to cholesterol synthesis in myelinating Schwann cells.
Data suggest that triiodothyronine (T3) acts as physiological regulator of functional maturation of islet beta-cells via induction of MAFA/c-Maf; T3 has a direct receptor-ligand interaction with MAFA/c-Maf promoter.
Title: Thyroid hormone promotes postnatal rat pancreatic β-cell development and glucose-responsive insulin secretion through MAFA.
v-maf musculoaponeurotic fibrosarcoma (avian) oncogene homolog (c-maf)is differentially expressed in alpha-cells where it regulates glucagon gene expression.
Title: Differentially expressed Maf family transcription factors, c-Maf and MafA, activate glucagon and insulin gene expression in pancreatic islet alpha- and beta-cells.
TACI activation can upregulate c-maf expression which, in turn, controls cyclin D2, and integrin beta7 gene expression in human myeloma cell lines
Title: TACI expression is associated with a mature bone marrow plasma cell signature and C-MAF overexpression in human myeloma cell lines.
Data show that FoxA2, Nkx2.2, and PDX-1 regulate islet beta-cell-specific mafA expression through conserved sequences located between base pairs -8118 and -7750 upstream from the transcription start site.
Title: FoxA2, Nkx2.2, and PDX-1 regulate islet beta-cell-specific mafA expression through conserved sequences located between base pairs -8118 and -7750 upstream from the transcription start site.
An Maf associated with late endosomes/lysososmes in microglia is described.
Title: Identification of macrophage/microglia activation factor (MAF) associated with late endosomes/lysosomes in microglial cells.

Submit: New GeneRIF Correction

General gene information

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Markers

AA957811 (e-PCR)
- UniSTS:261690

Maf (e-PCR), detects polymorphism
- UniSTS:231406

D19Wox13 (e-PCR)
- UniSTS:518651

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA binding	ISO Inferred from Sequence Orthology more info
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription activator activity, RNA polymerase II-specific	ISO Inferred from Sequence Orthology more info
enables DNA-binding transcription factor activity	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity	ISO Inferred from Sequence Orthology more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IDA Inferred from Direct Assay more info	PubMed
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables double-stranded DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables identical protein binding	IEA Inferred from Electronic Annotation more info
enables identical protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables protein-containing complex binding	IDA Inferred from Direct Assay more info	PubMed
enables sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
enables sequence-specific double-stranded DNA binding	IEA Inferred from Electronic Annotation more info
enables sequence-specific double-stranded DNA binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within cell development	ISO Inferred from Sequence Orthology more info
involved_in inner ear development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within inner ear development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within lens development in camera-type eye	ISO Inferred from Sequence Orthology more info
involved_in lens fiber cell differentiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in lens fiber cell differentiation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within lens fiber cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in megakaryocyte differentiation	IEA Inferred from Electronic Annotation more info
involved_in megakaryocyte differentiation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of gene expression	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in regulation of chondrocyte differentiation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of chondrocyte differentiation	ISO Inferred from Sequence Orthology more info
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
part_of RNA polymerase II transcription regulator complex	IEA Inferred from Electronic Annotation more info
part_of RNA polymerase II transcription regulator complex	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: transcription factor Maf

Names: C-Maf; bZip transcription factor c-maf; proto-oncogene c-maf; transcription factor Maf-2; v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_019318.2 → NP_062191.2 transcription factor Maf

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000019

UniProtKB/Swiss-Prot

P54844

Conserved Domains (2) summary

cd14718
Location:279 → 347

bZIP_Maf_large; Basic leucine zipper (bZIP) domain of large musculoaponeurotic fibrosarcoma (Maf) proteins: a DNA-binding and dimerization domain

pfam08383
Location:86 → 119

Maf_N; Maf N-terminal region

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086037.1 Reference GRCr8

Range

60259200..60622145 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039097958.2 → XP_038953886.1 transcription factor Maf isoform X2

UniProtKB/Swiss-Prot

P54844

UniProtKB/TrEMBL

F1LSV1

Conserved Domains (2) summary

cd14718
Location:279 → 347

bZIP_Maf_large; Basic leucine zipper (bZIP) domain of large musculoaponeurotic fibrosarcoma (Maf) proteins: a DNA-binding and dimerization domain

pfam08383
Location:86 → 119

Maf_N; Maf N-terminal region
XM_039097956.2 → XP_038953884.1 transcription factor Maf isoform X1

UniProtKB/Swiss-Prot

P54844

Related

ENSRNOP00000101124.1, ENSRNOT00000153831.1

Conserved Domains (2) summary

cd14718
Location:279 → 347

bZIP_Maf_large; Basic leucine zipper (bZIP) domain of large musculoaponeurotic fibrosarcoma (Maf) proteins: a DNA-binding and dimerization domain

pfam08383
Location:86 → 119

Maf_N; Maf N-terminal region
XM_039097957.2 → XP_038953885.1 transcription factor Maf isoform X2

UniProtKB/Swiss-Prot

P54844

UniProtKB/TrEMBL

F1LSV1

Conserved Domains (2) summary

cd14718
Location:279 → 347

bZIP_Maf_large; Basic leucine zipper (bZIP) domain of large musculoaponeurotic fibrosarcoma (Maf) proteins: a DNA-binding and dimerization domain

pfam08383
Location:86 → 119

Maf_N; Maf N-terminal region
XM_063278262.1 → XP_063134332.1 transcription factor Maf isoform X2

UniProtKB/Swiss-Prot

P54844

UniProtKB/TrEMBL

F1LSV1

Related

ENSRNOP00000016577.4, ENSRNOT00000016577.7
XM_006255696.5 → XP_006255758.1 transcription factor Maf isoform X3

UniProtKB/Swiss-Prot

P54844

UniProtKB/TrEMBL

A0A8I6B690

Related

ENSRNOP00000100324.1, ENSRNOT00000164218.1

Conserved Domains (2) summary

cd14718
Location:279 → 347

bZIP_Maf_large; Basic leucine zipper (bZIP) domain of large musculoaponeurotic fibrosarcoma (Maf) proteins: a DNA-binding and dimerization domain

pfam08383
Location:86 → 119

Maf_N; Maf N-terminal region