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    Ptprv protein tyrosine phosphatase, receptor type, V [ Rattus norvegicus (Norway rat) ]

    Gene ID: 64576, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Ptprvprovided by RGD
    Official Full Name
    protein tyrosine phosphatase, receptor type, Vprovided by RGD
    Primary source
    RGD:621123
    See related
    EnsemblRapid:ENSRNOG00000005277 AllianceGenome:RGD:621123
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Esp
    Summary
    Enables protein tyrosine phosphatase activity. Involved in several processes, including cellular response to cAMP; cellular response to epidermal growth factor stimulus; and cellular response to parathyroid hormone stimulus. Predicted to be located in membrane. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Testes (RPKM 77.4), Uterus (RPKM 24.6) and 3 other tissues See more
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    Genomic context

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    See Ptprv in Genome Data Viewer
    Location:
    13q13
    Exon count:
    35
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 13 NC_086031.1 (49099922..49120247, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 13 NC_051348.1 (46548125..46569148, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 13 NC_005112.4 (51935239..51956262, complement)

    Chromosome 13 - NC_086031.1Genomic Context describing neighboring genes Neighboring gene ubiquitin-conjugating enzyme E2T Neighboring gene leucine-rich repeat-containing G protein-coupled receptor 6 Neighboring gene uncharacterized LOC120096252 Neighboring gene protein tyrosine phosphatase, non-receptor type 7 Neighboring gene ARF like GTPase 8A

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Rat osteotesticular phosphatase gene (Esp): genomic structure and chromosome location. Lathrop W, et al. Mamm Genome, 1999 Apr. PMID 10087294
    2. Identification of a hormonally regulated protein tyrosine phosphatase associated with bone and testicular differentiation. Mauro LJ, et al. J Biol Chem, 1994 Dec 2. PMID 7527035
    3. Parathyroid hormone regulates the expression of the receptor protein tyrosine phosphatase, OST-PTP, in rat osteoblast-like cells. Mauro LJ, et al. Endocrinology, 1996 Mar. PMID 8603605
    4. Congenic mapping and sequence analysis of the Renin locus. Flister MJ, et al. Hypertension, 2013 Apr. PMID 23460292, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables histone H2AXY142 phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables non-membrane spanning protein tyrosine phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein tyrosine phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein tyrosine phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein tyrosine phosphatase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables protein tyrosine phosphatase activity, metal-dependent IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in axon guidance IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in bone remodeling IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in cellular response to cAMP IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in cellular response to epidermal growth factor stimulus IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in cellular response to parathyroid hormone stimulus IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in osteoclast development IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in peptidyl-tyrosine dephosphorylation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in spermatogenesis IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    receptor-type tyrosine-protein phosphatase V
    Names
    ES cell phosphatase
    OST-PTP
    Osteotesticular phosphatase
    R-PTP-V
    embryonic stem cell protein-tyrosine phosphatase
    osteotesticular protein-tyrosine phosphatase
    protein tyrosine phosphatase receptor type W
    NP_149090.1
    XP_038946996.1
    XP_038946997.1
    XP_038946998.1
    XP_038946999.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_033099.1 → NP_149090.1  receptor-type tyrosine-protein phosphatase V precursor

      See identical proteins and their annotated locations for NP_149090.1

      Status: PROVISIONAL

      Source sequence(s)
      L36884
      UniProtKB/Swiss-Prot
      Q64612
      UniProtKB/TrEMBL
      A0A8I6AM78
      Related
      ENSRNOP00000007597.3, ENSRNOT00000007597.7
      Conserved Domains (6) summary
      smart00060
      Location:473 → 547
      FN3; Fibronectin type 3 domain
      smart00194
      Location:1150 → 1408
      PTPc; Protein tyrosine phosphatase, catalytic domain
      cd00047
      Location:1177 → 1408
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
      cd00063
      Location:656 → 725
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam00041
      Location:131 → 201
      fn3; Fibronectin type III domain
      cl21483
      Location:1521 → 1693
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086031.1 Reference GRCr8

      Range
      49099922..49120247 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039091070.2 → XP_038946998.1  receptor-type tyrosine-protein phosphatase V isoform X3

      UniProtKB/TrEMBL
      A0A8I6AM78
      Conserved Domains (6) summary
      smart00060
      Location:473 → 547
      FN3; Fibronectin type 3 domain
      cd00063
      Location:656 → 725
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd14618
      Location:1120 → 1349
      R-PTPc-V; catalytic domain of receptor-type tyrosine-protein phosphatase V
      pfam00041
      Location:148 → 201
      fn3; Fibronectin type III domain
      pfam18861
      Location:950 → 1044
      PTP_tm; Transmembrane domain of protein tyrosine phosphatase, receptor type J
      cl28904
      Location:1419 → 1635
      PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily

    2. XM_039091068.2 → XP_038946996.1  receptor-type tyrosine-protein phosphatase V isoform X1

      UniProtKB/TrEMBL
      A0A8I6AM78, F1M8J3
      Related
      ENSRNOP00000095225.1, ENSRNOT00000110943.2
      Conserved Domains (6) summary
      smart00060
      Location:473 → 547
      FN3; Fibronectin type 3 domain
      cd00063
      Location:656 → 725
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd14618
      Location:1178 → 1407
      R-PTPc-V; catalytic domain of receptor-type tyrosine-protein phosphatase V
      pfam00041
      Location:148 → 201
      fn3; Fibronectin type III domain
      pfam18861
      Location:950 → 1102
      PTP_tm; Transmembrane domain of protein tyrosine phosphatase, receptor type J
      cl28904
      Location:1477 → 1693
      PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily

    3. XM_039091069.2 → XP_038946997.1  receptor-type tyrosine-protein phosphatase V isoform X2

      UniProtKB/TrEMBL
      A0A8I6AM78
      Conserved Domains (5) summary
      smart00060
      Location:432 → 506
      FN3; Fibronectin type 3 domain
      cd00063
      Location:615 → 684
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam00041
      Location:107 → 160
      fn3; Fibronectin type III domain
      pfam18861
      Location:909 → 1061
      PTP_tm; Transmembrane domain of protein tyrosine phosphatase, receptor type J
      cl28904
      Location:1137 → 1366
      PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily

    4. XM_039091071.2 → XP_038946999.1  receptor-type tyrosine-protein phosphatase V isoform X4

      UniProtKB/TrEMBL
      A6ICD7
      Conserved Domains (5) summary
      smart00060
      Location:473 → 547
      FN3; Fibronectin type 3 domain
      cd00063
      Location:656 → 725
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam00041
      Location:148 → 201
      fn3; Fibronectin type III domain
      pfam18861
      Location:950 → 1102
      PTP_tm; Transmembrane domain of protein tyrosine phosphatase, receptor type J
      cl28904
      Location:1178 → 1351
      PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q64612.1 GenPept UniProtKB/Swiss-Prot:Q64612

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