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    Ercc6l ERCC excision repair 6 like, spindle assembly checkpoint helicase [ Rattus norvegicus (Norway rat) ]

    Gene ID: 317252, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Ercc6lprovided by RGD
    Official Full Name
    ERCC excision repair 6 like, spindle assembly checkpoint helicaseprovided by RGD
    Primary source
    RGD:1565734
    See related
    EnsemblRapid:ENSRNOG00000003208 AllianceGenome:RGD:1565734
    Gene type
    protein coding
    RefSeq status
    INFERRED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1565734
    Summary
    Predicted to enable DNA translocase activity. Predicted to be involved in DNA repair. Orthologous to human ERCC6L (ERCC excision repair 6 like, spindle assembly checkpoint helicase). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 79.2), Spleen (RPKM 51.6) and 8 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Ercc6l in Genome Data Viewer
    Location:
    Xq22
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) X NC_086039.1 (71285380..71301186, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) X NC_051356.1 (67245414..67261222, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) X NC_005120.4 (72018373..72034140, complement)

    Chromosome X - NC_086039.1Genomic Context describing neighboring genes Neighboring gene NHS-like 2 Neighboring gene retrotransposon Gag like 5 Neighboring gene uncharacterized LOC134484080 Neighboring gene peptidylprolyl cis/trans isomerase, NIMA-interacting 4 Neighboring gene small nuclear ribonucleoprotein D2 polypeptide, pseudogene 2 Neighboring gene ribosomal protein S4, X-linked

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. ERCC6L promotes cell growth and invasion in human colorectal cancer. Xie Y, et al. Oncol Lett, 2019 Jul. PMID 31289493, Free PMC Article
    2. ERCC6L is a biomarker and therapeutic target for non-small cell lung adenocarcinoma. Hou G, et al. Med Oncol, 2022 Feb 12. PMID 35150321
    3. PICH: a DNA translocase specially adapted for processing anaphase bridge DNA. Biebricher A, et al. Mol Cell, 2013 Sep 12. PMID 23973328, Free PMC Article
    4. Ercc6l, a gene of SNF2 family, may play a role in the teratogenic action of alcohol. Xu Y, et al. Toxicol Lett, 2005 Jul 4. PMID 15917148
    5. Defining the membrane proteome of NK cells. Ghosh D, et al. J Mass Spectrom, 2010 Jan. PMID 19946888

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Characterization of the mouse Ercc6l ortholog.
      Title: Ercc6l, a gene of SNF2 family, may play a role in the teratogenic action of alcohol.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA translocase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables DNA translocase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables helicase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA repair IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    DNA excision repair protein ERCC-6-like
    Names
    excision repair cross-complementation group 6-like
    excision repair cross-complementing rodent repair deficiency complementation group 6 - like
    excision repair cross-complementing rodent repair deficiency complementation group 6-like
    NP_001092144.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001098674.1 → NP_001092144.1  DNA excision repair protein ERCC-6-like

      See identical proteins and their annotated locations for NP_001092144.1

      Status: INFERRED

      Source sequence(s)
      JAXUCZ010000021
      UniProtKB/TrEMBL
      A0A8I6GF73, A6IQE3, D4A0G9
      Related
      ENSRNOP00000004310.4, ENSRNOT00000004310.8
      Conserved Domains (3) summary
      cd00046
      Location:116 → 259
      DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
      pfam00176
      Location:99 → 417
      SNF2_N; SNF2 family N-terminal domain
      pfam00271
      Location:461 → 576
      Helicase_C; Helicase conserved C-terminal domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086039.1 Reference GRCr8

      Range
      71285380..71301186 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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