Mfsd12 major facilitator superfamily domain containing 12 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Mfsd12provided by RGD
Official Full Name: major facilitator superfamily domain containing 12provided by RGD
Primary source: RGD:1307722
See related: EnsemblRapid:ENSRNOG00000039858 AllianceGenome:RGD:1307722
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: RGD1307722
Summary: Predicted to enable cysteine transmembrane transporter activity. Predicted to be involved in cysteine transmembrane transport; negative regulation of melanin biosynthetic process; and pigment metabolic process involved in pigmentation. Predicted to act upstream of or within hair follicle development and pigmentation. Predicted to be located in late endosome; lysosome; and melanosome. Predicted to be active in plasma membrane. Orthologous to human MFSD12 (major facilitator superfamily domain containing 12). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Spleen (RPKM 105.4), Brain (RPKM 97.4) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 7q11

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	7	NC_086025.1 (8998050..9004724, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	7	NC_051342.1 (8345171..8354050, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	7	NC_005106.4 (11214832..11223713, complement)

Chromosome 7 - NC_086025.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables cysteine transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables cysteine transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables symporter activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in carbohydrate transport	IEA Inferred from Electronic Annotation more info
involved_in cysteine transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in cysteine transmembrane transport	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within hair follicle development	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of melanin biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in pigment metabolic process involved in pigmentation	IBA Inferred from Biological aspect of Ancestor more info
involved_in pigment metabolic process involved in pigmentation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within pigmentation	ISO Inferred from Sequence Orthology more info
involved_in regulation of melanin biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of melanin biosynthetic process	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in late endosome	ISO Inferred from Sequence Orthology more info
located_in lysosome	ISO Inferred from Sequence Orthology more info
located_in melanosome	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: major facilitator superfamily domain-containing protein 12

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001108730.1 → NP_001102200.1 major facilitator superfamily domain-containing protein 12

See identical proteins and their annotated locations for NP_001102200.1

Status: PROVISIONAL

Source sequence(s)

CH474029

UniProtKB/TrEMBL

A6K886, F1M4E3

Related

ENSRNOP00000057905.3, ENSRNOT00000061191.5

Conserved Domains (1) summary

cl21472
Location:14 → 390

MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...