Med13 mediator complex subunit 13 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Med13provided by RGD
Official Full Name: mediator complex subunit 13provided by RGD
Primary source: RGD:1304829
See related: EnsemblRapid:ENSRNOG00000003679 AllianceGenome:RGD:1304829
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Thrap1
Summary: Predicted to enable nuclear thyroid hormone receptor binding activity and transcription coactivator activity. Predicted to be involved in cholesterol homeostasis; regulation of DNA-templated transcription; and triglyceride homeostasis. Predicted to be located in nucleoplasm. Predicted to be part of CKM complex and mediator complex. Human ortholog(s) of this gene implicated in autosomal dominant intellectual developmental disorder. Orthologous to human MED13 (mediator complex subunit 13). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Thymus (RPKM 434.7), Kidney (RPKM 265.5) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 10q26

Exon count:: 33

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	10	NC_086028.1 (71584354..71674614, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	10	NC_051345.1 (71086978..71176535, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	10	NC_005109.4 (73702327..73787084, complement)

Chromosome 10 - NC_086028.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Exercise training can prevent weight gain and pathological cardiac hypertrophy via increased of cardiac MED13 by the regulation of miRNA-208a.
Title: Exercise training prevents obesity-associated disorders: Role of miRNA-208a and MED13.

Submit: New GeneRIF Correction

General gene information

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Markers

BI295544 (e-PCR)
- UniSTS:246659

D10Got95 (e-PCR)
- UniSTS:115850

D10Chm79 (e-PCR)
- UniSTS:518061

D17S1598 (e-PCR)
- UniSTS:153543

D10Chm213 (e-PCR)
- UniSTS:518349

THRAP1__5254 (e-PCR)
- UniSTS:464605

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables nuclear thyroid hormone receptor binding	ISO Inferred from Sequence Orthology more info
enables transcription coactivator activity	IBA Inferred from Biological aspect of Ancestor more info
enables transcription coactivator activity	ISO Inferred from Sequence Orthology more info
enables transcription coregulator activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in biological_process	ND No biological Data available more info
involved_in cholesterol homeostasis	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of DNA-binding transcription factor activity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transcription initiation by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in triglyceride homeostasis	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of CKM complex	ISO Inferred from Sequence Orthology more info
part_of mediator complex	IBA Inferred from Biological aspect of Ancestor more info
part_of mediator complex	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: mediator of RNA polymerase II transcription subunit 13

Names: thyroid hormone receptor associated protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001415085.1 → NP_001402014.1 mediator of RNA polymerase II transcription subunit 13

Status: VALIDATED

Source sequence(s)

JAXUCZ010000010

UniProtKB/TrEMBL

F1LXU0

Related

ENSRNOP00000032864.6, ENSRNOT00000035280.7

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086028.1 Reference GRCr8

Range

71584354..71674614 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039086047.2 → XP_038941975.1 mediator of RNA polymerase II transcription subunit 13 isoform X1

UniProtKB/TrEMBL

A0A8I5YBV3, A6HHQ5

Conserved Domains (2) summary

pfam06333
Location:1626 → 2029

Med13_C; Mediator complex subunit 13 C-terminal

pfam18296
Location:1235 → 1590

MID_MedPIWI; MID domain of medPIWI