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    Jrk Jrk helix-turn-helix protein [ Rattus norvegicus (Norway rat) ]

    Gene ID: 315073, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Jrkprovided by RGD
    Official Full Name
    Jrk helix-turn-helix proteinprovided by RGD
    Primary source
    RGD:1306316
    See related
    EnsemblRapid:ENSRNOG00000027238 AllianceGenome:RGD:1306316
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable DNA binding activity and mRNA binding activity. Predicted to be involved in positive regulation of canonical Wnt signaling pathway. Predicted to be located in cytoplasm. Predicted to be part of ribonucleoprotein complex. Predicted to be active in nucleus. Orthologous to human JRK (Jrk helix-turn-helix protein). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Testes (RPKM 52.9), Thymus (RPKM 41.8) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Jrk in Genome Data Viewer
    Location:
    7q34
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (108479646..108484329, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (106590662..106595345, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (115941788..115946471, complement)

    Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134479925 Neighboring gene U6 spliceosomal RNA Neighboring gene activity-regulated cytoskeleton-associated protein Neighboring gene prostate stem cell antigen Neighboring gene thioesterase superfamily member 6 Neighboring gene secreted Ly6/Plaur domain containing 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Jerky, a protein deficient in a mouse epilepsy model, is associated with translationally inactive mRNA in neurons. Liu W, et al. J Neurosci, 2002 Jan 1. PMID 11756500, Free PMC Article
    2. Jerky/Earthbound facilitates cell-specific Wnt/Wingless signalling by modulating β-catenin-TCF activity. Benchabane H, et al. EMBO J, 2011 Apr 20. PMID 21399610, Free PMC Article
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables mRNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in positive regulation of canonical Wnt signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of ribonucleoprotein complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    NOT located_in ribosome ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    jerky protein homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001104612.2 → NP_001098082.1  jerky protein homolog

      See identical proteins and their annotated locations for NP_001098082.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000007
      UniProtKB/TrEMBL
      A0A8I5ZTF2, A7YY82
      Related
      ENSRNOP00000099750.1, ENSRNOT00000135023.1
      Conserved Domains (3) summary
      smart00674
      Location:83 → 147
      CENPB; Putative DNA-binding domain in centromere protein B, mouse jerky and transposases
      pfam03184
      Location:213 → 382
      DDE_1; DDE superfamily endonuclease
      pfam04218
      Location:14 → 66
      CENP-B_N; CENP-B N-terminal DNA-binding domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086025.1 Reference GRCr8

      Range
      108479646..108484329 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006241728.4 → XP_006241790.1  jerky protein homolog isoform X1

      See identical proteins and their annotated locations for XP_006241790.1

      UniProtKB/TrEMBL
      A0A8I5ZTF2, A7YY82
      Related
      ENSRNOP00000105530.1, ENSRNOT00000157132.1
      Conserved Domains (3) summary
      smart00674
      Location:83 → 147
      CENPB; Putative DNA-binding domain in centromere protein B, mouse jerky and transposases
      pfam03184
      Location:213 → 382
      DDE_1; DDE superfamily endonuclease
      pfam04218
      Location:14 → 66
      CENP-B_N; CENP-B N-terminal DNA-binding domain
    Nucleotide Protein Strain
    Heading Accession and Version

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