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    Sgo1 shugoshin 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 363174, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Sgo1provided by RGD
    Official Full Name
    shugoshin 1provided by RGD
    Primary source
    RGD:1593238
    See related
    EnsemblRapid:ENSRNOG00000022499 AllianceGenome:RGD:1593238
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Sgol1
    Summary
    Predicted to enable kinase binding activity. Predicted to be involved in attachment of spindle microtubules to kinetochore and mitotic sister chromatid cohesion, centromeric. Predicted to act upstream of or within centriole-centriole cohesion and meiotic chromosome segregation. Predicted to be located in several cellular components, including kinetochore; microtubule cytoskeleton; and nucleoplasm. Human ortholog(s) of this gene implicated in chronic atrial and intestinal dysrhythmia. Orthologous to human SGO1 (shugoshin 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Thymus (RPKM 73.1), Spleen (RPKM 53.3) and 8 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Sgo1 in Genome Data Viewer
    Location:
    9q11
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 9 NC_086027.1 (6908661..6943483, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 9 NC_051344.1 (6672109..6687908, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 9 NC_005108.4 (4420158..4435939)

    Chromosome 9 - NC_086027.1Genomic Context describing neighboring genes Neighboring gene RAB5A, member RAS oncogene family Neighboring gene protein phosphatase 2C-like domain containing 1 Neighboring gene lysine acetyltransferase 2B Neighboring gene small nucleolar RNA SNORA48 Neighboring gene RIKEN cDNA 4932415M13 gene like Neighboring gene sulfotransferase 1C2-like

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Cohesin-protein Shugoshin-1 controls cardiac automaticity via HCN4 pacemaker channel. Liu D, et al. Nat Commun, 2021 May 5. PMID 33953173, Free PMC Article
    2. Differential subcellular localizations of two human Sgo1 isoforms: implications in regulation of sister chromatid cohesion and microtubule dynamics. Wang X, et al. Cell Cycle, 2006 Mar. PMID 16582621
    3. Phospho-H2A and cohesin specify distinct tension-regulated Sgo1 pools at kinetochores and inner centromeres. Liu H, et al. Curr Biol, 2013 Oct 7. PMID 24055156
    4. Phosphorylation of human Sgo1 by NEK2A is essential for chromosome congression in mitosis. Fu G, et al. Cell Res, 2007 Jul. PMID 17621308
    5. Shugoshin 1 plays a central role in kinetochore assembly and is required for kinetochore targeting of Plk1. Pouwels J, et al. Cell Cycle, 2007 Jul 1. PMID 17617734

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Cohesin-protein Shugoshin-1 controls cardiac automaticity via HCN4 pacemaker channel.
      Title: Cohesin-protein Shugoshin-1 controls cardiac automaticity via HCN4 pacemaker channel.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables kinase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in attachment of spindle microtubules to kinetochore ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cell division IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within centriole-centriole cohesion ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in centriole-centriole cohesion ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in chromosome segregation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within meiotic chromosome segregation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in mitotic sister chromatid cohesion, centromeric ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in centrosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in chromosome, centromeric region ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in condensed chromosome, centromeric region ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in kinetochore ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in spindle pole ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    shugoshin 1
    Names
    shugoshin-like 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001399344.1 → NP_001386273.1  shugoshin 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000009
      UniProtKB/TrEMBL
      D4A624
      Conserved Domains (2) summary
      pfam07557
      Location:467 → 489
      Shugoshin_C; Shugoshin C-terminus
      pfam07558
      Location:22 → 66
      Shugoshin_N; Shugoshin N-terminal coiled-coil region

    2. NM_001399345.1 → NP_001386274.1  shugoshin 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000009
      UniProtKB/TrEMBL
      D4A624
      Related
      ENSRNOP00000061236.3, ENSRNOT00000065721.4
      Conserved Domains (2) summary
      pfam07557
      Location:467 → 489
      Shugoshin_C; Shugoshin C-terminus
      pfam07558
      Location:22 → 66
      Shugoshin_N; Shugoshin N-terminal coiled-coil region

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086027.1 Reference GRCr8

      Range
      6908661..6943483 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063267351.1 → XP_063123421.1  shugoshin 1 isoform X1

      UniProtKB/TrEMBL
      D4A624

    2. XM_063267352.1 → XP_063123422.1  shugoshin 1 isoform X1

      UniProtKB/TrEMBL
      D4A624

    3. XM_039084402.2 → XP_038940330.1  shugoshin 1 isoform X2

      Conserved Domains (2) summary
      pfam07557
      Location:466 → 488
      Shugoshin_C; Shugoshin C-terminus
      pfam07558
      Location:22 → 66
      Shugoshin_N; Shugoshin N-terminal coiled-coil region

    4. XM_063267353.1 → XP_063123423.1  shugoshin 1 isoform X2

    Nucleotide Protein Strain
    Heading Accession and Version

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