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    Kcnip4 potassium voltage-gated channel interacting protein 4 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 259243, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Kcnip4provided by RGD
    Official Full Name
    potassium voltage-gated channel interacting protein 4provided by RGD
    Primary source
    RGD:708539
    See related
    EnsemblRapid:ENSRNOG00000032350 AllianceGenome:RGD:708539
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Kchip4
    Summary
    Enables potassium channel regulator activity. Involved in protein localization to plasma membrane and regulation of potassium ion transmembrane transport. Located in several cellular components, including cytosol; dendrite; and neuronal cell body. Part of voltage-gated potassium channel complex. Orthologous to human KCNIP4 (potassium voltage-gated channel interacting protein 4). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Brain (RPKM 158.8), Uterus (RPKM 43.9) and 1 other tissue See more
    Orthologs
    human mouse all
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    Genomic context

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    See Kcnip4 in Genome Data Viewer
    Location:
    14q11
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 14 NC_086032.1 (65593297..66743994)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 14 NC_051349.1 (61380699..62531399)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 14 NC_005113.4 (65549362..66749181)

    Chromosome 14 - NC_086032.1Genomic Context describing neighboring genes Neighboring gene galectin 9, pseudogene 2 Neighboring gene interferon induced transmembrane protein3, pseudogene 1 Neighboring gene uncharacterized LOC134481849 Neighboring gene chaperonin containing TCP1 subunit 6A, pseudogene 18 Neighboring gene dyskerin pseudouridine synthase 1, pseudogene 1 Neighboring gene eukaryotic translation elongation factor 1 alpha 1, pseudogene 20 Neighboring gene parkin coregulated like Neighboring gene slit guidance ligand 2 Neighboring gene microRNA 218-1 Neighboring gene microRNA 3565

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Down-regulation of miR-3068-3p enhances kcnip4-regulated A-type potassium current to protect against glutamate-induced excitotoxicity. Su ZJ, et al. J Neurochem, 2020 Jun. PMID 31792968
    2. Regulation of KChIP2 potassium channel beta subunit gene expression underlies the gradient of transient outward current in canine and human ventricle. Rosati B, et al. J Physiol, 2001 May 15. PMID 11351020, Free PMC Article
    3. Structural Insights into KChIP4a Modulation of Kv4.3 Inactivation. Liang P, et al. J Biol Chem, 2009 Feb 20. PMID 19109250
    4. The stoichiometry and biophysical properties of the Kv4 potassium channel complex with K+ channel-interacting protein (KChIP) subunits are variable, depending on the relative expression level. Kitazawa M, et al. J Biol Chem, 2014 Jun 20. PMID 24811166, Free PMC Article
    5. Distribution and functional expression of Kv4 family α subunits and associated KChIP β subunits in the bed nucleus of the stria terminalis. Rainnie DG, et al. J Comp Neurol, 2014 Feb 15. PMID 24037673, Free PMC Article

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Down-regulation of miR-3068-3p enhances kcnip4-regulated A-type potassium current to protect against glutamate-induced excitotoxicity.
      Title: Down-regulation of miR-3068-3p enhances kcnip4-regulated A-type potassium current to protect against glutamate-induced excitotoxicity.
    2. Subunit counting by single-molecule imaging revealed that the bound number of KChIP4 in each Kv4.2.KChIP4 complex was dependent on the expression level of KChIP4.
      Title: The stoichiometry and biophysical properties of the Kv4 potassium channel complex with K+ channel-interacting protein (KChIP) subunits are variable, depending on the relative expression level.
    3. This study demonistrared that the expression and function of KCHIP4 channels in neurons of the rat bed nucleus of the stria terminalis.
      Title: Distribution and functional expression of Kv4 family α subunits and associated KChIP β subunits in the bed nucleus of the stria terminalis.
    4. KChIP4a isoform, which exhibits unique effects on Kv4 channel gating negatively influences the impact of other KChIPs
      Title: A fundamental role for KChIPs in determining the molecular properties and trafficking of Kv4.2 potassium channels.
    5. KChIP4 coassociates with Kv4 subunits in hippocampal membranes, confirming that the KChIPs are tightly associated with Kv4 subunits in native brain A-type channel complexes which may play a major role as modulators of somatodendritic excitability.
      Title: KChIPs and Kv4 alpha subunits as integral components of A-type potassium channels in mammalian brain.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables calcium ion binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables calcium ion binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables calcium ion binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables potassium channel activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables potassium channel regulator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables potassium channel regulator activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables potassium channel regulator activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables potassium channel regulator activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in potassium ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein localization to plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of potassium ion transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of potassium ion transmembrane transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of potassium ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of potassium ion transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in dendrite IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of monoatomic ion channel complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in neuronal cell body IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in peroxisome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in peroxisome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in peroxisome ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of voltage-gated potassium channel complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of voltage-gated potassium channel complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of voltage-gated potassium channel complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of voltage-gated potassium channel complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    Kv channel-interacting protein 4
    Names
    A-type potassium channel modulatory protein 4
    Kv channel interacting protein 4
    potassium channel-interacting protein 4

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001433864.1 → NP_001420793.1  Kv channel-interacting protein 4 isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000014

    2. NM_181365.3 → NP_852030.1  Kv channel-interacting protein 4 isoform 1

      See identical proteins and their annotated locations for NP_852030.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000014
      UniProtKB/Swiss-Prot
      Q99MG8, Q99MG9
      UniProtKB/TrEMBL
      G3V9C1
      Related
      ENSRNOP00000042016.6, ENSRNOT00000049743.6
      Conserved Domains (1) summary
      COG5126
      Location:80 → 239
      FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086032.1 Reference GRCr8

      Range
      65593297..66743994
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063272886.1 → XP_063128956.1  Kv channel-interacting protein 4 isoform X1

      UniProtKB/TrEMBL
      A6IJJ6

    2. XM_017599089.3 → XP_017454578.1  Kv channel-interacting protein 4 isoform X5

      UniProtKB/TrEMBL
      G3V9C1
      Related
      ENSRNOP00000086123.2, ENSRNOT00000115304.2
      Conserved Domains (1) summary
      COG5126
      Location:46 → 205
      FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]

    3. XM_017599088.3 → XP_017454577.1  Kv channel-interacting protein 4 isoform X4

      UniProtKB/TrEMBL
      A0A8I5ZMG1, G3V9C1
      Related
      ENSRNOP00000079125.1, ENSRNOT00000115977.2
      Conserved Domains (1) summary
      COG5126
      Location:55 → 214
      FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]

    4. XM_017599087.3 → XP_017454576.1  Kv channel-interacting protein 4 isoform X3

      UniProtKB/TrEMBL
      A0A8I6A8J8, G3V9C1
      Related
      ENSRNOP00000089378.1, ENSRNOT00000114580.2
      Conserved Domains (1) summary
      COG5126
      Location:59 → 218
      FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]

    5. XM_017599086.3 → XP_017454575.1  Kv channel-interacting protein 4 isoform X2

      UniProtKB/TrEMBL
      A0A8I5ZSB5, G3V9C1
      Related
      ENSRNOP00000075583.3, ENSRNOT00000079658.3
      Conserved Domains (1) summary
      COG5126
      Location:63 → 222
      FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]

    6. XM_063272887.1 → XP_063128957.1  Kv channel-interacting protein 4 isoform X6

      UniProtKB/TrEMBL
      A0A0G2KAZ2, A6IJJ8
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q99MG9.1 GenPept UniProtKB/Swiss-Prot:Q99MG9

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