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    Stoml1 stomatin like 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 300748, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Stoml1provided by RGD
    Official Full Name
    stomatin like 1provided by RGD
    Primary source
    RGD:1559463
    See related
    EnsemblRapid:ENSRNOG00000008530 AllianceGenome:RGD:1559463
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1559463
    Summary
    Predicted to enable ion channel inhibitor activity. Predicted to act upstream of or within cellular response to leukemia inhibitory factor. Predicted to be located in cytoplasmic vesicle. Predicted to be active in plasma membrane. Orthologous to human STOML1 (stomatin like 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Brain (RPKM 90.1), Lung (RPKM 34.7) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Stoml1 in Genome Data Viewer
    Location:
    8q24
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (67557846..67565734)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (58661980..58669860)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (63037135..63045024)

    Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134480059 Neighboring gene PML nuclear body scaffold Neighboring gene lysyl oxidase-like 1 Neighboring gene ribosomal protein L38, pseudogene 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Subunit-specific inhibition of acid sensing ion channels by stomatin-like protein 1. Kozlenkov A, et al. J Physiol, 2014 Feb 15. PMID 24247984, Free PMC Article
    2. TGF-β/Smad2/3 signaling directly regulates several miRNAs in mouse ES cells and early embryos. Redshaw N, et al. PLoS One, 2013. PMID 23390484, Free PMC Article
    3. miRNA 34a, 100, and 137 modulate differentiation of mouse embryonic stem cells. Tarantino C, et al. FASEB J, 2010 Sep. PMID 20439489
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ion channel inhibitor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within cellular response to leukemia inhibitory factor ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasmic vesicle ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    stomatin-like protein 1
    Names
    stomatin (EPB72)-like 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001305238.1 → NP_001292167.1  stomatin-like protein 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000008
      UniProtKB/TrEMBL
      A6J4Z9, D4A7E9
      Related
      ENSRNOP00000011383.5, ENSRNOT00000011383.9
      Conserved Domains (3) summary
      smart00244
      Location:77 → 217
      PHB; prohibitin homologues
      cd13436
      Location:94 → 224
      SPFH_SLP-1; Stomatin-like protein 1 (SLP-1), a subgroup of the stomatin-like proteins (slipins) family; belonging to the SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily
      pfam02036
      Location:304 → 395
      SCP2; SCP-2 sterol transfer family

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086026.1 Reference GRCr8

      Range
      67557846..67565734
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006243184.5 → XP_006243246.1  stomatin-like protein 1 isoform X1

      See identical proteins and their annotated locations for XP_006243246.1

      UniProtKB/TrEMBL
      A6J4Z9
      Conserved Domains (3) summary
      smart00244
      Location:83 → 167
      PHB; prohibitin homologues
      pfam02036
      Location:254 → 345
      SCP2; SCP-2 sterol transfer family
      cl19107
      Location:79 → 174
      SPFH_like; core domain of the SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily
    Nucleotide Protein Strain
    Heading Accession and Version

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