Hipk1 homeodomain interacting protein kinase 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Hipk1provided by RGD
Official Full Name: homeodomain interacting protein kinase 1provided by RGD
Primary source: RGD:1304941
See related: EnsemblRapid:ENSRNOG00000019333 AllianceGenome:RGD:1304941
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable protein serine/threonine kinase activity and protein tyrosine kinase activity. Predicted to be involved in several processes, including apoptotic signaling pathway; camera-type eye morphogenesis; and endothelial cell apoptotic process. Predicted to act upstream of or within anterior/posterior pattern specification and positive regulation of cell population proliferation. Predicted to be located in centrosome; cytosol; and nuclear speck. Predicted to be active in PML body and cytoplasm. Orthologous to human HIPK1 (homeodomain interacting protein kinase 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Thymus (RPKM 364.5), Spleen (RPKM 316.5) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 2q34

Exon count:: 22

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	2	NC_086020.1 (193937261..193988247, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	2	NC_051337.1 (191248817..191299787, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	2	NC_005101.4 (206224015..206274910, complement)

Chromosome 2 - NC_086020.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH136831 (e-PCR)
- UniSTS:218920

SHGC-16738 (e-PCR)
- UniSTS:31536

RH144541 (e-PCR)
- UniSTS:233786

RH143441 (e-PCR)
- UniSTS:232688

RH139604 (e-PCR)
- UniSTS:221688

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables 3-phosphoinositide-dependent protein kinase activity	IEA Inferred from Electronic Annotation more info
enables AMP-activated protein kinase activity	IEA Inferred from Electronic Annotation more info
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables DNA-dependent protein kinase activity	IEA Inferred from Electronic Annotation more info
enables Rho-dependent protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info
enables eukaryotic translation initiation factor 2alpha kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AS1 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AS121 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AT120 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AXS139 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2BS14 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2BS36 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3S10 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3S28 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3S57 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T11 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T3 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T45 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T6 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H4S1 kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info
enables protein tyrosine kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables ribosomal protein S6 kinase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in adherens junction assembly	IEA Inferred from Electronic Annotation more info
involved_in adherens junction assembly	ISO Inferred from Sequence Orthology more info
involved_in anterior/posterior pattern specification	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within anterior/posterior pattern specification	ISO Inferred from Sequence Orthology more info
involved_in cell population proliferation	IEA Inferred from Electronic Annotation more info
acts_upstream_of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in chromatin remodeling	IEA Inferred from Electronic Annotation more info
involved_in embryonic camera-type eye morphogenesis	IEA Inferred from Electronic Annotation more info
involved_in embryonic camera-type eye morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in embryonic retina morphogenesis in camera-type eye	IEA Inferred from Electronic Annotation more info
involved_in embryonic retina morphogenesis in camera-type eye	ISO Inferred from Sequence Orthology more info
involved_in endothelial cell apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in endothelial cell apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in extrinsic apoptotic signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in extrinsic apoptotic signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator	IBA Inferred from Biological aspect of Ancestor more info
involved_in intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator	ISO Inferred from Sequence Orthology more info
involved_in iris morphogenesis	IEA Inferred from Electronic Annotation more info
involved_in iris morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in lens induction in camera-type eye	IEA Inferred from Electronic Annotation more info
involved_in lens induction in camera-type eye	ISO Inferred from Sequence Orthology more info
involved_in neuron differentiation	IEA Inferred from Electronic Annotation more info
involved_in neuron differentiation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell population proliferation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in protein phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in regulation of tumor necrosis factor-mediated signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in regulation of tumor necrosis factor-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in retina layer formation	IEA Inferred from Electronic Annotation more info
involved_in retina layer formation	ISO Inferred from Sequence Orthology more info
involved_in smoothened signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in smoothened signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within smoothened signaling pathway	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in PML body	IBA Inferred from Biological aspect of Ancestor more info
located_in PML body	IEA Inferred from Electronic Annotation more info
located_in PML body	ISO Inferred from Sequence Orthology more info
located_in centrosome	IEA Inferred from Electronic Annotation more info
located_in centrosome	ISO Inferred from Sequence Orthology more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in nuclear speck	IEA Inferred from Electronic Annotation more info
located_in nuclear speck	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: homeodomain-interacting protein kinase 1

NP_001094456.1

EC 2.7.11.1

XP_008759642.1

EC 2.7.11.1

XP_038958716.1

EC 2.7.11.1

XP_038958717.1

EC 2.7.11.1

XP_038958720.2

EC 2.7.11.1

XP_038958721.2

EC 2.7.11.1

XP_038958722.2

EC 2.7.11.1

XP_038958723.1

EC 2.7.11.1

XP_063138349.1

EC 2.7.11.1

XP_063138350.1

EC 2.7.11.1

XP_063138352.1

EC 2.7.11.1

XP_063138353.1

EC 2.7.11.1

XP_063138354.1

EC 2.7.11.1

XP_063138355.1

EC 2.7.11.1

XP_063138356.1

EC 2.7.11.1

XP_063138357.1

EC 2.7.11.1

XP_063138358.1

EC 2.7.11.1

XP_063138359.1

EC 2.7.11.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001100986.1 → NP_001094456.1 homeodomain-interacting protein kinase 1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000002

UniProtKB/Swiss-Prot

A4L9P5, A4L9P6

UniProtKB/TrEMBL

F1M8I6

Related

ENSRNOP00000061079.3, ENSRNOT00000056079.6

Conserved Domains (2) summary

PHA03247
Location:618 → 925

PHA03247; large tegument protein UL36; Provisional

cd14228
Location:174 → 528

STKc_HIPK1; Catalytic domain of the Serine/Threonine Kinase, Homeodomain-Interacting Protein Kinase 1

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086020.1 Reference GRCr8

Range

193937261..193988247 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063282287.1 → XP_063138357.1 homeodomain-interacting protein kinase 1 isoform X9

UniProtKB/Swiss-Prot

A4L9P5, A4L9P6
XM_063282284.1 → XP_063138354.1 homeodomain-interacting protein kinase 1 isoform X6

UniProtKB/Swiss-Prot

A4L9P5, A4L9P6
XM_063282280.1 → XP_063138350.1 homeodomain-interacting protein kinase 1 isoform X2

UniProtKB/Swiss-Prot

A4L9P5, A4L9P6
XM_039102794.2 → XP_038958722.2 homeodomain-interacting protein kinase 1 isoform X11

UniProtKB/Swiss-Prot

A4L9P5, A4L9P6
XM_039102792.2 → XP_038958720.2 homeodomain-interacting protein kinase 1 isoform X5

UniProtKB/Swiss-Prot

A4L9P5, A4L9P6
XM_039102793.2 → XP_038958721.2 homeodomain-interacting protein kinase 1 isoform X10

UniProtKB/Swiss-Prot

A4L9P5, A4L9P6
XM_063282279.1 → XP_063138349.1 homeodomain-interacting protein kinase 1 isoform X1

UniProtKB/Swiss-Prot

A4L9P5, A4L9P6
XM_063282285.1 → XP_063138355.1 homeodomain-interacting protein kinase 1 isoform X7

UniProtKB/Swiss-Prot

A4L9P5, A4L9P6
XM_063282286.1 → XP_063138356.1 homeodomain-interacting protein kinase 1 isoform X8

UniProtKB/Swiss-Prot

A4L9P5, A4L9P6
XM_063282283.1 → XP_063138353.1 homeodomain-interacting protein kinase 1 isoform X4

UniProtKB/Swiss-Prot

A4L9P5, A4L9P6

UniProtKB/TrEMBL

F1M8I6
XM_063282288.1 → XP_063138358.1 homeodomain-interacting protein kinase 1 isoform X3

UniProtKB/Swiss-Prot

A4L9P5, A4L9P6
XM_039102789.1 → XP_038958717.1 homeodomain-interacting protein kinase 1 isoform X3

UniProtKB/Swiss-Prot

A4L9P5, A4L9P6

Conserved Domains (2) summary

PHA03247
Location:623 → 930

PHA03247; large tegument protein UL36; Provisional

cd14228
Location:174 → 528

STKc_HIPK1; Catalytic domain of the Serine/Threonine Kinase, Homeodomain-Interacting Protein Kinase 1
XM_008761420.4 → XP_008759642.1 homeodomain-interacting protein kinase 1 isoform X8

UniProtKB/Swiss-Prot

A4L9P5, A4L9P6

Conserved Domains (2) summary

smart00220
Location:190 → 518

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd14228
Location:174 → 528

STKc_HIPK1; Catalytic domain of the Serine/Threonine Kinase, Homeodomain-Interacting Protein Kinase 1
XM_039102788.1 → XP_038958716.1 homeodomain-interacting protein kinase 1 isoform X3

UniProtKB/Swiss-Prot

A4L9P5, A4L9P6

Conserved Domains (2) summary

PHA03247
Location:623 → 930

PHA03247; large tegument protein UL36; Provisional

cd14228
Location:174 → 528

STKc_HIPK1; Catalytic domain of the Serine/Threonine Kinase, Homeodomain-Interacting Protein Kinase 1
XM_063282282.1 → XP_063138352.1 homeodomain-interacting protein kinase 1 isoform X3

UniProtKB/Swiss-Prot

A4L9P5, A4L9P6
XM_039102795.2 → XP_038958723.1 homeodomain-interacting protein kinase 1 isoform X13

Conserved Domains (1) summary

cl21453
Location:1 → 154

PKc_like; Protein Kinases, catalytic domain
XM_063282289.1 → XP_063138359.1 homeodomain-interacting protein kinase 1 isoform X12

UniProtKB/Swiss-Prot

A4L9P5, A4L9P6