Tspan5 tetraspanin 5 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Tspan5provided by RGD
Official Full Name: tetraspanin 5provided by RGD
Primary source: RGD:1303176
See related: EnsemblRapid:ENSRNOG00000015913 AllianceGenome:RGD:1303176
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Tm4sf9; Tspan-5
Summary: Predicted to enable enzyme binding activity. Predicted to be involved in several processes, including positive regulation of Notch signaling pathway; protein localization to plasma membrane; and regulation of membrane protein ectodomain proteolysis. Predicted to be located in actin cytoskeleton and nucleoplasm. Predicted to be active in plasma membrane. Orthologous to human TSPAN5 (tetraspanin 5). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Brain (RPKM 139.5), Kidney (RPKM 90.8) and 8 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 2q44

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	2	NC_086020.1 (229967521..230139012)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	2	NC_051337.1 (227294180..227469361)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	2	NC_005101.4 (244058186..244224059)

Chromosome 2 - NC_086020.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The tetraspanin TSPAN5 regulates AMPAR exocytosis by interacting with the AP4 complex.
Title: The tetraspanin TSPAN5 regulates AMPAR exocytosis by interacting with the AP4 complex.

Submit: New GeneRIF Correction

General gene information

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Markers

RH137962 (e-PCR)
- UniSTS:220049

RH143648 (e-PCR)
- UniSTS:232894

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables enzyme binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in cell adhesion	TAS Traceable Author Statement more info	PubMed
involved_in positive regulation of Notch signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in protein localization to plasma membrane	ISO Inferred from Sequence Orthology more info
involved_in protein maturation	ISO Inferred from Sequence Orthology more info
involved_in regulation of membrane protein ectodomain proteolysis	ISO Inferred from Sequence Orthology more info
involved_in regulation of membrane protein ectodomain proteolysis	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in actin cytoskeleton	IEA Inferred from Electronic Annotation more info
located_in actin cytoskeleton	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: tetraspanin-5

Names: tetraspan 5; transmembrane 4 superfamily member 9

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001004090.2 → NP_001004090.2 tetraspanin-5

See identical proteins and their annotated locations for NP_001004090.2

Status: PROVISIONAL

Source sequence(s)

BC100135

UniProtKB/Swiss-Prot

Q498N9, Q68VK5

UniProtKB/TrEMBL

A0A8I6A0T6, A6HW42

Related

ENSRNOP00000100821.1, ENSRNOT00000154137.1

Conserved Domains (2) summary

cd03159
Location:113 → 233

TM4SF9_like_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), TM4SF9_like subfamily. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment ...

pfam00335
Location:15 → 257

Tetraspannin; Tetraspanin family

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086020.1 Reference GRCr8

Range

229967521..230139012

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039102726.2 → XP_038958654.1 tetraspanin-5 isoform X1

UniProtKB/TrEMBL

A0A8I6A0T6, A0A8I6A2L2

Related

ENSRNOP00000084759.1, ENSRNOT00000111381.2

Conserved Domains (1) summary

cd03159
Location:64 → 184

TM4SF9_like_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), TM4SF9_like subfamily. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment ...