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    Tars2 threonyl-tRNA synthetase 2, mitochondrial [ Rattus norvegicus (Norway rat) ]

    Gene ID: 310672, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Tars2provided by RGD
    Official Full Name
    threonyl-tRNA synthetase 2, mitochondrialprovided by RGD
    Primary source
    RGD:1308283
    See related
    EnsemblRapid:ENSRNOG00000057194 AllianceGenome:RGD:1308283
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Tarsl1; RGD1308283
    Summary
    Predicted to enable aminoacyl-tRNA editing activity; protein homodimerization activity; and threonine-tRNA ligase activity. Predicted to be involved in threonyl-tRNA aminoacylation. Predicted to be located in mitochondrial matrix. Predicted to be active in mitochondrion. Human ortholog(s) of this gene implicated in combined oxidative phosphorylation deficiency 21. Orthologous to human TARS2 (threonyl-tRNA synthetase 2, mitochondrial). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Heart (RPKM 84.1), Adrenal (RPKM 71.7) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Tars2 in Genome Data Viewer
    Location:
    2q34
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (185982042..185999155, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (183293095..183310210, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (197861071..197881347, complement)

    Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120100878 Neighboring gene uncharacterized LOC120100879 Neighboring gene extracellular matrix protein 1 Neighboring gene regulation of nuclear pre-mRNA domain containing 2 Neighboring gene transfer RNA proline (anticodon AGG) 87 Neighboring gene pre-mRNA processing factor 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. A Human Disease-causing Point Mutation in Mitochondrial Threonyl-tRNA Synthetase Induces Both Structural and Functional Defects. Wang Y, et al. J Biol Chem, 2016 Mar 18. PMID 26811336, Free PMC Article
    2. Quantitative high-confidence human mitochondrial proteome and its dynamics in cellular context. Morgenstern M, et al. Cell Metab, 2021 Dec 7. PMID 34800366, Free PMC Article
    3. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables aminoacyl-tRNA editing activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables aminoacyl-tRNA editing activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein homodimerization activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables threonine-tRNA ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables threonine-tRNA ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables threonine-tRNA ligase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables threonine-tRNA ligase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in aminoacyl-tRNA metabolism involved in translational fidelity IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in threonyl-tRNA aminoacylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in threonyl-tRNA aminoacylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrial matrix IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    threonine--tRNA ligase, mitochondrial
    Names
    thrRS
    threonyl-tRNA synthetase 2, mitochondrial (putative)
    threonyl-tRNA synthetase, mitochondrial
    threonyl-tRNA synthetase-like 1
    NP_001014062.1
    XP_038958296.1
    XP_038958297.1
    XP_038958299.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001014040.1 → NP_001014062.1  threonine--tRNA ligase, mitochondrial

      See identical proteins and their annotated locations for NP_001014062.1

      Status: PROVISIONAL

      Source sequence(s)
      BC079154
      UniProtKB/Swiss-Prot
      Q68FW7
      UniProtKB/TrEMBL
      A0A8I6A3R3
      Related
      ENSRNOP00000072886.1, ENSRNOT00000087052.3
      Conserved Domains (5) summary
      cd01667
      Location:66 → 127
      TGS_ThrRS_N; TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and ...
      PLN02908
      Location:34 → 715
      PLN02908; threonyl-tRNA synthetase
      smart00863
      Location:234 → 281
      tRNA_SAD; Threonyl and Alanyl tRNA synthetase second additional domain
      cd00771
      Location:305 → 618
      ThrRS_core; Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent ...
      cd00860
      Location:618 → 709
      ThrRS_anticodon; ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is ...

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086020.1 Reference GRCr8

      Range
      185982042..185999155 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039102369.2 → XP_038958297.1  threonine--tRNA ligase, mitochondrial isoform X2

      UniProtKB/TrEMBL
      A0A8I5ZU30, A0A8I6A6X1
      Related
      ENSRNOP00000082736.1, ENSRNOT00000106748.2
      Conserved Domains (1) summary
      PLN02908
      Location:34 → 634
      PLN02908; threonyl-tRNA synthetase

    2. XM_039102368.2 → XP_038958296.1  threonine--tRNA ligase, mitochondrial isoform X1

      UniProtKB/TrEMBL
      A0A8I6GH23, A6K310
      Related
      ENSRNOP00000088405.1, ENSRNOT00000104982.2
      Conserved Domains (1) summary
      PLN02908
      Location:34 → 666
      PLN02908; threonyl-tRNA synthetase

    3. XM_039102371.2 → XP_038958299.1  threonine--tRNA ligase, mitochondrial isoform X3

      Conserved Domains (1) summary
      PLN02908
      Location:3 → 476
      PLN02908; threonyl-tRNA synthetase
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q68FW7.1 GenPept UniProtKB/Swiss-Prot:Q68FW7

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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