Tle6 TLE family member 6, subcortical maternal complex member [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Tle6provided by RGD
Official Full Name: TLE family member 6, subcortical maternal complex memberprovided by RGD
Primary source: RGD:1561530
See related: EnsemblRapid:ENSRNOG00000006350 AllianceGenome:RGD:1561530
Gene type: protein coding
RefSeq status: MODEL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: RGD1561530
Summary: Predicted to enable transcription corepressor activity. Predicted to be involved in several processes, including cytoskeleton organization; embryonic process involved in female pregnancy; and negative regulation of canonical Wnt signaling pathway. Predicted to act upstream of or within positive regulation of neurogenesis and positive regulation of neuron differentiation. Predicted to be located in cell cortex. Predicted to be part of subcortical maternal complex and transcription regulator complex. Predicted to be active in nucleus. Orthologous to human TLE6 (TLE family member 6, subcortical maternal complex member). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Adrenal (RPKM 13.9), Kidney (RPKM 8.9) and 6 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 7q11

Exon count:: 17

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	7	NC_086025.1 (8757846..8769405)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	7	NC_051342.1 (8107050..8118639)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	7	NC_005106.4 (10964136..10988127)

Chromosome 7 - NC_086025.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables transcription corepressor activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in actin filament organization	ISO Inferred from Sequence Orthology more info
involved_in embryonic process involved in female pregnancy	ISO Inferred from Sequence Orthology more info
involved_in endoplasmic reticulum localization	ISO Inferred from Sequence Orthology more info
involved_in establishment of spindle localization	ISO Inferred from Sequence Orthology more info
involved_in mitochondrion localization	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of canonical Wnt signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of embryonic development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of neurogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of neuron differentiation	ISO Inferred from Sequence Orthology more info
involved_in regulation of cell division	ISO Inferred from Sequence Orthology more info
involved_in spermatogonial cell division	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cell cortex	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info
part_of subcortical maternal complex	ISO Inferred from Sequence Orthology more info
part_of transcription regulator complex	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: transducin-like enhancer protein 6

Names: transducin-like enhancer of split 6 (E(sp1) homolog, Drosophila)

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086025.1 Reference GRCr8

Range

8757846..8769405

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039080433.2 → XP_038936361.1 transducin-like enhancer protein 6 isoform X1

UniProtKB/TrEMBL

A0A8I5ZVQ7

Conserved Domains (2) summary

sd00039
Location:252 → 306

7WD40; WD40 repeat [structural motif]

cl29593
Location:251 → 538

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
XM_006241027.4 → XP_006241089.2 transducin-like enhancer protein 6 isoform X1

UniProtKB/TrEMBL

A0A8I5ZVQ7

Conserved Domains (2) summary

sd00039
Location:252 → 306

7WD40; WD40 repeat [structural motif]

cl29593
Location:251 → 538

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
XM_006241030.5 → XP_006241092.2 transducin-like enhancer protein 6 isoform X2

UniProtKB/TrEMBL

A0A8I5ZVQ7

Related

ENSRNOP00000008360.9, ENSRNOT00000008360.10

Conserved Domains (2) summary

sd00039
Location:226 → 280

7WD40; WD40 repeat [structural motif]

cl29593
Location:225 → 512

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
XM_063264486.1 → XP_063120556.1 transducin-like enhancer protein 6 isoform X3

UniProtKB/TrEMBL

A0A8I5ZVQ7

Related

ENSRNOP00000081779.1, ENSRNOT00000109747.2
XM_063264487.1 → XP_063120557.1 transducin-like enhancer protein 6 isoform X3

UniProtKB/TrEMBL

A0A8I5ZVQ7
XM_017595153.3 → XP_017450642.2 transducin-like enhancer protein 6 isoform X3

UniProtKB/TrEMBL

A0A8I5ZVQ7

Conserved Domains (2) summary

sd00039
Location:209 → 263

7WD40; WD40 repeat [structural motif]

cl29593
Location:208 → 495

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...