Spc24 SPC24 component of NDC80 kinetochore complex [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Spc24provided by RGD
Official Full Name: SPC24 component of NDC80 kinetochore complexprovided by RGD
Primary source: RGD:1307631
See related: EnsemblRapid:ENSRNOG00000029862 AllianceGenome:RGD:1307631
Gene type: protein coding
RefSeq status: INFERRED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Spbc24; Spc24-ps1; RGD1307631
Summary: Predicted to contribute to microtubule binding activity. Predicted to be involved in attachment of spindle microtubules to kinetochore. Predicted to be located in kinetochore; nucleolus; and nucleoplasm. Predicted to be part of Ndc80 complex. Orthologous to human SPC24 (SPC24 component of NDC80 kinetochore complex). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Thymus (RPKM 53.7), Spleen (RPKM 36.3) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 8q13

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	8	NC_086026.1 (28576409..28581481, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	8	NC_051343.1 (20300315..20305354, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	8	NC_005107.4 (22780639..22785908, complement)

Chromosome 8 - NC_086026.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Gene expressions of ELOVL6 and SPC24 were upregulated, and SERPINA7 was downregulated in the livers of rats with ventromedial hypothalamic lesions.
Title: Gene expression profiling in rat liver after VMH lesioning.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
contributes_to microtubule binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in attachment of spindle microtubules to kinetochore	ISO Inferred from Sequence Orthology more info
involved_in cell division	IEA Inferred from Electronic Annotation more info
involved_in chromosome segregation	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
part_of Ndc80 complex	IBA Inferred from Biological aspect of Ancestor more info
part_of Ndc80 complex	ISO Inferred from Sequence Orthology more info
located_in kinetochore	ISO Inferred from Sequence Orthology more info
located_in nucleolus	IEA Inferred from Electronic Annotation more info
located_in nucleolus	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
part_of outer kinetochore	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: kinetochore protein Spc24

Names: SPC24, NDC80 kinetochore complex component, homolog, pseudogene 1; spindle pole body component 24 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001398872.1 → NP_001385801.1 kinetochore protein Spc24

Status: INFERRED

Source sequence(s)

JAXUCZ010000008

Related

ENSRNOP00000045819.7, ENSRNOT00000045384.7

Conserved Domains (2) summary

TIGR02168
Location:17 → 127

SMC_prok_B; chromosome segregation protein SMC, common bacterial type

pfam08286
Location:83 → 192

Spc24; Spc24 subunit of Ndc80

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086026.1 Reference GRCr8

Range

28576409..28581481 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039082256.2 → XP_038938184.1 kinetochore protein Spc24 isoform X1

UniProtKB/TrEMBL

D4A1C5

Conserved Domains (2) summary

TIGR02168
Location:17 → 127

SMC_prok_B; chromosome segregation protein SMC, common bacterial type

pfam08286
Location:83 → 129

Spc24; Spc24 subunit of Ndc80