Dlg3 discs large MAGUK scaffold protein 3 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Dlg3provided by RGD
Official Full Name: discs large MAGUK scaffold protein 3provided by RGD
Primary source: RGD:68423
See related: EnsemblRapid:ENSRNOG00000002767 AllianceGenome:RGD:68423
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Dlgh3
Summary: Enables PDZ domain binding activity; ionotropic glutamate receptor binding activity; and protein phosphatase binding activity. A structural constituent of postsynaptic density. Predicted to be involved in several processes, including establishment or maintenance of epithelial cell apical/basal polarity; protein localization to synapse; and receptor clustering. Predicted to act upstream of or within establishment of planar polarity. Located in several cellular components, including dendritic shaft; growth cone; and postsynaptic density. Is active in glutamatergic synapse and postsynaptic density, intracellular component. Human ortholog(s) of this gene implicated in non-syndromic X-linked intellectual disability 90. Orthologous to human DLG3 (discs large MAGUK scaffold protein 3). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Brain (RPKM 139.6), Lung (RPKM 68.9) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: Xq22

Exon count:: 25

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	X	NC_086039.1 (69899694..69951928)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	X	NC_051356.1 (65859653..65911887)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	X	NC_005120.4 (70596246..70648529)

Chromosome X - NC_086039.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

SAP102 contributes to hyperalgesia formation in the cancer induced bone pain rat model by anchoring NMDA receptors.
Title: SAP102 contributes to hyperalgesia formation in the cancer induced bone pain rat model by anchoring NMDA receptors.
Our findings provide fundamental data to support the functional differences of SAP102 in different hippocampal subregions during postnatal periods
Title: Dynamic SAP102 expression in the hippocampal subregions of rats and APP/PS1 mice of various ages.
SAP102 regulates synaptic current kinetics via different AMPAR auxiliary subunits.
Title: SAP102 regulates synaptic AMPAR function through a CNIH-2-dependent mechanism.
These data shed new light on the role of SAP102 in the regulation of NMDAR trafficking.
Title: Subunit-specific regulation of N-methyl-D-aspartate (NMDA) receptor trafficking by SAP102 protein splice variants.
the contribution of the hydrophobic core and of the extended C terminus of A2A adenosine receptor in hippocampal neurons
Title: A two-state model for the diffusion of the A2A adenosine receptor in hippocampal neurons: agonist-induced switch to slow mobility is modified by synapse-associated protein 102 (SAP102).
our current study identified a functional interplay between PSD-95 and synapse-associated protein 102 (SAP102) to regulate synaptic AMPA receptors
Title: Synaptic state-dependent functional interplay between postsynaptic density-95 and synapse-associated protein 102.
This study demonistrated that SAP102 is necessary for EphB/PAK signaling and proper glutamate synapse development.
Title: Postsynaptic density scaffold SAP102 regulates cortical synapse development through EphB and PAK signaling pathway.
The data of this study provided the first evidence that SAP102 links NMDA receptor activation to alterations in spine morphology.
Title: NMDA receptor-dependent regulation of dendritic spine morphology by SAP102 splice variants.
Significant differences in the localization, binding mechanism, and mobility of SAP102 and PSD-95 are shown.
Title: SAP102 is a highly mobile MAGUK in spines.
SAP102 and PSD-95 regulate the synaptic trafficking of distinct glutamate receptor subtypes at different developmental stages, thereby playing necessary roles in excitatory synapse development.
Title: Differential trafficking of AMPA and NMDA receptors by SAP102 and PSD-95 underlies synapse development.

Submit: New GeneRIF Correction See all GeneRIFs (13)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables PDZ domain binding	IPI Inferred from Physical Interaction more info	PubMed
enables ionotropic glutamate receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables ionotropic glutamate receptor binding	IPI Inferred from Physical Interaction more info	PubMed
enables kinase binding	IEA Inferred from Electronic Annotation more info
enables kinase binding	ISO Inferred from Sequence Orthology more info
enables phosphatase binding	IEA Inferred from Electronic Annotation more info
enables phosphatase binding	ISO Inferred from Sequence Orthology more info
enables phosphatase binding	ISS Inferred from Sequence or Structural Similarity more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein domain specific binding	IDA Inferred from Direct Assay more info	PubMed
enables protein kinase binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein phosphatase binding	IPI Inferred from Physical Interaction more info	PubMed
enables structural constituent of postsynaptic density	IDA Inferred from Direct Assay more info	PubMed
enables structural constituent of postsynaptic density	IMP Inferred from Mutant Phenotype more info	PubMed
enables ubiquitin protein ligase binding	IEA Inferred from Electronic Annotation more info
enables ubiquitin protein ligase binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in cell-cell adhesion	IBA Inferred from Biological aspect of Ancestor more info
involved_in chemical synaptic transmission	IBA Inferred from Biological aspect of Ancestor more info
involved_in chemical synaptic transmission	IEA Inferred from Electronic Annotation more info
involved_in establishment of planar polarity	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within establishment of planar polarity	ISO Inferred from Sequence Orthology more info
involved_in establishment or maintenance of epithelial cell apical/basal polarity	IBA Inferred from Biological aspect of Ancestor more info
involved_in establishment or maintenance of epithelial cell apical/basal polarity	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within establishment or maintenance of epithelial cell apical/basal polarity	ISO Inferred from Sequence Orthology more info
involved_in maintenance of postsynaptic density structure	IEA Inferred from Electronic Annotation more info
involved_in nervous system development	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein localization to synapse	IBA Inferred from Biological aspect of Ancestor more info
involved_in receptor clustering	IBA Inferred from Biological aspect of Ancestor more info
involved_in receptor localization to synapse	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of postsynaptic membrane neurotransmitter receptor levels	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of postsynaptic membrane neurotransmitter receptor levels	IEA Inferred from Electronic Annotation more info
involved_in regulation of postsynaptic membrane neurotransmitter receptor levels	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of AMPA glutamate receptor complex	IEA Inferred from Electronic Annotation more info
part_of AMPA glutamate receptor complex	ISO Inferred from Sequence Orthology more info
is_active_in basolateral plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in bicellular tight junction	IEA Inferred from Electronic Annotation more info
located_in bicellular tight junction	ISO Inferred from Sequence Orthology more info
located_in cell-cell junction	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in dendritic shaft	IDA Inferred from Direct Assay more info	PubMed
is_active_in glutamatergic synapse	IDA Inferred from Direct Assay more info	PubMed
located_in glutamatergic synapse	IEA Inferred from Electronic Annotation more info
is_active_in glutamatergic synapse	IMP Inferred from Mutant Phenotype more info	PubMed
is_active_in glutamatergic synapse	ISO Inferred from Sequence Orthology more info
located_in glutamatergic synapse	ISO Inferred from Sequence Orthology more info
located_in growth cone	IDA Inferred from Direct Assay more info	PubMed
is_active_in neuromuscular junction	IBA Inferred from Biological aspect of Ancestor more info
located_in neuromuscular junction	IEA Inferred from Electronic Annotation more info
is_active_in neuron projection	IBA Inferred from Biological aspect of Ancestor more info
located_in neuron projection	IEA Inferred from Electronic Annotation more info
located_in neuronal cell body	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in postsynaptic density	IDA Inferred from Direct Assay more info	PubMed
located_in postsynaptic density	TAS Traceable Author Statement more info	PubMed
is_active_in postsynaptic density membrane	IBA Inferred from Biological aspect of Ancestor more info
is_active_in postsynaptic density, intracellular component	IDA Inferred from Direct Assay more info	PubMed
located_in synapse	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: disks large homolog 3

Names: PSD-95/SAP90-related protein 1; SAP-102; SAP102; discs, large homolog 3; synapse-associated protein 102

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_031639.2 → NP_113827.1 disks large homolog 3

See identical proteins and their annotated locations for NP_113827.1

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000021

UniProtKB/Swiss-Prot

P70547, Q62936

UniProtKB/TrEMBL

A0A8I6A7U5, A6IQ92

Related

ENSRNOP00000003741.2, ENSRNOT00000003741.8

Conserved Domains (6) summary

cd12029
Location:520 → 586

SH3_DLG3; Src Homology 3 domain of Disks Large homolog 3

smart00072
Location:669 → 836

GuKc; Guanylate kinase homologues

cd00992
Location:402 → 480

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

pfam00625
Location:658 → 836

Guanylate_kin; Guanylate kinase

pfam10600
Location:329 → 403

PDZ_assoc; PDZ-associated domain of NMDA receptors

pfam10608
Location:52 → 148

MAGUK_N_PEST; Polyubiquitination (PEST) N-terminal domain of MAGUK

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086039.1 Reference GRCr8

Range

69899694..69951928

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063280268.1 → XP_063136338.1 disks large homolog 3 isoform X7
XM_008773267.4 → XP_008771489.1 disks large homolog 3 isoform X2

UniProtKB/TrEMBL

A0A8I5Y1U1

Related

ENSRNOP00000078000.1, ENSRNOT00000076450.4

Conserved Domains (6) summary

cd12029
Location:520 → 586

SH3_DLG3; Src Homology 3 domain of Disks Large homolog 3

smart00072
Location:673 → 840

GuKc; Guanylate kinase homologues

cd00992
Location:402 → 480

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

pfam00625
Location:662 → 840

Guanylate_kin; Guanylate kinase

pfam10600
Location:329 → 403

PDZ_assoc; PDZ-associated domain of NMDA receptors

pfam10608
Location:52 → 148

MAGUK_N_PEST; Polyubiquitination (PEST) N-terminal domain of MAGUK
XM_006257080.5 → XP_006257142.1 disks large homolog 3 isoform X1

UniProtKB/TrEMBL

A0A0G2K0Y9, A0A8I5Y1U1

Related

ENSRNOP00000067983.2, ENSRNOT00000076079.4

Conserved Domains (6) summary

cd12029
Location:520 → 586

SH3_DLG3; Src Homology 3 domain of Disks Large homolog 3

smart00072
Location:687 → 854

GuKc; Guanylate kinase homologues

cd00992
Location:402 → 480

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

pfam00625
Location:676 → 854

Guanylate_kin; Guanylate kinase

pfam10600
Location:329 → 403

PDZ_assoc; PDZ-associated domain of NMDA receptors

pfam10608
Location:52 → 148

MAGUK_N_PEST; Polyubiquitination (PEST) N-terminal domain of MAGUK
XM_006257081.5 → XP_006257143.1 disks large homolog 3 isoform X3

UniProtKB/TrEMBL

A0A8I5Y1U1

Related

ENSRNOP00000071634.2, ENSRNOT00000088114.3

Conserved Domains (6) summary

cd12029
Location:502 → 568

SH3_DLG3; Src Homology 3 domain of Disks Large homolog 3

smart00072
Location:669 → 836

GuKc; Guanylate kinase homologues

cd00992
Location:384 → 462

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

pfam00625
Location:658 → 836

Guanylate_kin; Guanylate kinase

pfam10600
Location:311 → 385

PDZ_assoc; PDZ-associated domain of NMDA receptors

pfam10608
Location:52 → 130

MAGUK_N_PEST; Polyubiquitination (PEST) N-terminal domain of MAGUK
XM_006257082.5 → XP_006257144.1 disks large homolog 3 isoform X4

See identical proteins and their annotated locations for XP_006257144.1

UniProtKB/TrEMBL

A0A8I6A7U5

Related

ENSRNOP00000047310.3, ENSRNOT00000045082.8

Conserved Domains (6) summary

cd12029
Location:520 → 586

SH3_DLG3; Src Homology 3 domain of Disks Large homolog 3

smart00072
Location:655 → 822

GuKc; Guanylate kinase homologues

cd00992
Location:402 → 480

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

pfam00625
Location:644 → 822

Guanylate_kin; Guanylate kinase

pfam10600
Location:329 → 403

PDZ_assoc; PDZ-associated domain of NMDA receptors

pfam10608
Location:52 → 148

MAGUK_N_PEST; Polyubiquitination (PEST) N-terminal domain of MAGUK
XM_063280267.1 → XP_063136337.1 disks large homolog 3 isoform X5

UniProtKB/TrEMBL

A0A8I6ATE5
XM_006257083.5 → XP_006257145.1 disks large homolog 3 isoform X6

UniProtKB/TrEMBL

A0A096MJ42, A0A8I6ATE5

Conserved Domains (6) summary

cd12029
Location:502 → 568

SH3_DLG3; Src Homology 3 domain of Disks Large homolog 3

smart00072
Location:637 → 804

GuKc; Guanylate kinase homologues

cd00992
Location:384 → 462

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

pfam00625
Location:626 → 804

Guanylate_kin; Guanylate kinase

pfam10600
Location:311 → 385

PDZ_assoc; PDZ-associated domain of NMDA receptors

pfam10608
Location:52 → 130

MAGUK_N_PEST; Polyubiquitination (PEST) N-terminal domain of MAGUK
XM_006257084.4 → XP_006257146.1 disks large homolog 3 isoform X8

UniProtKB/TrEMBL

A0A8I5ZLU7

Related

ENSRNOP00000078849.1, ENSRNOT00000076503.4

Conserved Domains (4) summary

smart00072
Location:332 → 499

GuKc; Guanylate kinase homologues

cd00992
Location:47 → 125

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

pfam00625
Location:321 → 499

Guanylate_kin; Guanylate kinase

cl17036
Location:165 → 231

SH3; Src Homology 3 domain superfamily
XM_008773268.4 → XP_008771490.1 disks large homolog 3 isoform X10

See identical proteins and their annotated locations for XP_008771490.1

Conserved Domains (3) summary

cd12029
Location:19 → 85

SH3_DLG3; Src Homology 3 domain of Disks Large homolog 3

smart00072
Location:186 → 353

GuKc; Guanylate kinase homologues

pfam00625
Location:175 → 353

Guanylate_kin; Guanylate kinase
XM_063280269.1 → XP_063136339.1 disks large homolog 3 isoform X9
XM_006257085.5 → XP_006257147.1 disks large homolog 3 isoform X10

See identical proteins and their annotated locations for XP_006257147.1

Conserved Domains (3) summary

cd12029
Location:19 → 85

SH3_DLG3; Src Homology 3 domain of Disks Large homolog 3

smart00072
Location:186 → 353

GuKc; Guanylate kinase homologues

pfam00625
Location:175 → 353

Guanylate_kin; Guanylate kinase
XM_063280270.1 → XP_063136340.1 disks large homolog 3 isoform X11
XM_063280271.1 → XP_063136341.1 disks large homolog 3 isoform X12