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    Reep5 receptor accessory protein 5 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 364838, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Reep5provided by RGD
    Official Full Name
    receptor accessory protein 5provided by RGD
    Primary source
    RGD:1306047
    See related
    EnsemblRapid:ENSRNOG00000020167 AllianceGenome:RGD:1306047
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Dp1
    Summary
    Predicted to be involved in endoplasmic reticulum membrane organization. Predicted to be located in endoplasmic reticulum tubular network and junctional sarcoplasmic reticulum membrane. Orthologous to human REEP5 (receptor accessory protein 5). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Adrenal (RPKM 795.8), Brain (RPKM 489.4) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Reep5 in Genome Data Viewer
    Location:
    18p12
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 18 NC_086036.1 (26219528..26257505, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 18 NC_051353.1 (25945375..25983271, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 18 NC_005117.4 (27128462..27159693, complement)

    Chromosome 18 - NC_086036.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102549857 Neighboring gene APC regulator of WNT signaling pathway Neighboring gene signal recognition particle 19 Neighboring gene signal recognition particle 19, pseudogene 2 Neighboring gene polycystin 2 like 2, transient receptor potential cation channel Neighboring gene Set nuclear proto-oncogene, pseudogene 8 Neighboring gene family with sequence similarity 13, member B

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. REEP5 (Receptor Accessory Protein 5) Acts as a Sarcoplasmic Reticulum Membrane Sculptor to Modulate Cardiac Function. Yao L, et al. J Am Heart Assoc, 2018 Feb 3. PMID 29431104, Free PMC Article
    2. Protrudin regulates endoplasmic reticulum morphology and function associated with the pathogenesis of hereditary spastic paraplegia. Hashimoto Y, et al. J Biol Chem, 2014 May 9. PMID 24668814, Free PMC Article
    3. Protrudin binds atlastins and endoplasmic reticulum-shaping proteins and regulates network formation. Chang J, et al. Proc Natl Acad Sci U S A, 2013 Sep 10. PMID 23969831, Free PMC Article
    4. Proteomic analysis of podocyte exosome-enriched fraction from normal human urine. Prunotto M, et al. J Proteomics, 2013 Apr 26. PMID 23376485
    5. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. REEP5 modulates cardiac function by shaping the sarcoplasmic reticulum. REEP5 defect deforms the SR architecture to depress cardiac contractility in heart failure.
      Title: REEP5 (Receptor Accessory Protein 5) Acts as a Sarcoplasmic Reticulum Membrane Sculptor to Modulate Cardiac Function.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in endoplasmic reticulum membrane organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in endoplasmic reticulum membrane organization ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endoplasmic reticulum tubular network IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum tubular network ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endoplasmic reticulum tubular network ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in junctional sarcoplasmic reticulum membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in sarcoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in sarcoplasmic reticulum membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    receptor expression-enhancing protein 5
    Names
    deleted in polyposis 1
    polyposis locus protein 1 homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001108888.2 → NP_001102358.2  receptor expression-enhancing protein 5

      See identical proteins and their annotated locations for NP_001102358.2

      Status: VALIDATED

      Source sequence(s)
      AA819308, BC167013, BE126660, BP503102, FM032375
      UniProtKB/Swiss-Prot
      B2RZ37
      UniProtKB/TrEMBL
      A0A8I6AL10
      Related
      ENSRNOP00000027345.6, ENSRNOT00000027345.7
      Conserved Domains (1) summary
      pfam03134
      Location:67 → 144
      TB2_DP1_HVA22; TB2/DP1, HVA22 family

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086036.1 Reference GRCr8

      Range
      26219528..26257505 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039097000.2 → XP_038952928.1  receptor expression-enhancing protein 5 isoform X1

      Conserved Domains (1) summary
      pfam03134
      Location:38 → 115
      TB2_DP1_HVA22; TB2/DP1, HVA22 family
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    B2RZ37.1 GenPept UniProtKB/Swiss-Prot:B2RZ37

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
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