Nrep neuronal regeneration related protein [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Nrepprovided by RGD
Official Full Name: neuronal regeneration related proteinprovided by RGD
Primary source: RGD:631411
See related: EnsemblRapid:ENSRNOG00000068914 AllianceGenome:RGD:631411
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: P311
Summary: Involved in axon regeneration and regulation of neuron differentiation. Predicted to be located in cytoplasm. Orthologous to human NREP (neuronal regeneration related protein). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Muscle (RPKM 596.9), Brain (RPKM 471.1) and 8 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 18p12

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	18	NC_086036.1 (25291219..25320742, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	18	NC_051353.1 (25017069..25046593, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	18	NC_005117.4 (26183753..26212796, complement)

Chromosome 18 - NC_086036.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

P311 knockdown alleviates hyperoxia-induced injury by inactivating the Smad3 signaling pathway in type II alveolar epithelial cells.
Title: P311 knockdown alleviates hyperoxia-induced injury by inactivating the Smad3 signaling pathway in type II alveolar epithelial cells.
P311 may be involved in the pathogenesis of renal fibrosis by blocking TGF-beta1-mediated epithelial-mesenchymal transition via TGF-beta1-Smad-ILK pathway in unilateral ureteral occlusion kidneys.
Title: Adenovirus-mediated P311 ameliorates renal fibrosis through inhibition of epithelial-mesenchymal transition via TGF-β1-Smad-ILK pathway in unilateral ureteral obstruction rats.
efficiently blocked Smad-ILK pathway activation and attenuated epithelial-mesenchymal transition induced by TGF-beta1
Title: Adenovirus-mediated P311 inhibits TGF-β1-induced epithelial-mesenchymal transition in NRK-52E cells via TGF-β1-Smad-ILK pathway.
P311 gene, together with alpha-SMA and TGF-beta1 genes, was induced in the process of Tubular epithelial-myofibroblast transition (TEMT) in rat.
Title: Role of P311 in interleukin-1α-induced epithelial to myofibroblast transition in kidney tubular epithelial cells.
identified a gene, previously designated P311, up-regulated in axotomized facial motoneurons; ectopically expressed P311 localizes in the cytoplasm and the nucleus; over-expression of P311 induces p21(WAF1/Cip1), leading PC12 cells to differentiate [P311]
Title: P311 accelerates nerve regeneration of the axotomized facial nerve.

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General gene information

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Markers

PMC151607P1 (e-PCR)
- UniSTS:271151

G54138 (e-PCR)
- UniSTS:109375

RH11754 (e-PCR)
- UniSTS:84896

Gene Ontology Provided by RGD

Process	Evidence Code	Pubs
involved_in axon regeneration	IBA Inferred from Biological aspect of Ancestor more info
involved_in axon regeneration	IEP Inferred from Expression Pattern more info	PubMed
involved_in regulation of neuron differentiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of neuron differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of transforming growth factor beta receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within regulation of transforming growth factor beta receptor signaling pathway	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: neuronal regeneration-related protein

Names: neuronal protein 3.1; protein p311

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001419560.1 → NP_001406489.1 neuronal regeneration-related protein

Status: VALIDATED

Source sequence(s)

JAXUCZ010000018

UniProtKB/Swiss-Prot

Q80Z34

UniProtKB/TrEMBL

A6J2S2

Related

ENSRNOP00000086813.1, ENSRNOT00000119499.2
NM_001419561.1 → NP_001406490.1 neuronal regeneration-related protein

Status: VALIDATED

Source sequence(s)

JAXUCZ010000018

UniProtKB/Swiss-Prot

Q80Z34

UniProtKB/TrEMBL

A6J2S2

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086036.1 Reference GRCr8

Range

25291219..25320742 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063277456.1 → XP_063133526.1 neuronal regeneration-related protein isoform X1

UniProtKB/Swiss-Prot

Q80Z34

UniProtKB/TrEMBL

A6J2S2
XM_063277457.1 → XP_063133527.1 neuronal regeneration-related protein isoform X1

UniProtKB/Swiss-Prot

Q80Z34

UniProtKB/TrEMBL

A6J2S2