Hapln1 hyaluronan and proteoglycan link protein 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Hapln1provided by RGD
Official Full Name: hyaluronan and proteoglycan link protein 1provided by RGD
Primary source: RGD:2412
See related: EnsemblRapid:ENSRNOG00000032002 AllianceGenome:RGD:2412
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Crtl1
Summary: Predicted to enable hyaluronic acid binding activity and structural molecule activity. Predicted to be involved in nervous system development; positive regulation of neuroblast proliferation; and skeletal system development. Predicted to be located in extracellular matrix. Predicted to be active in extracellular space; perineuronal net; and synapse. Orthologous to human HAPLN1 (hyaluronan and proteoglycan link protein 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Brain (RPKM 94.9), Heart (RPKM 9.4) and 1 other tissue See more
Orthologs: human mouse all
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Genomic context

Location:: 2q12

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	2	NC_086020.1 (22366967..22431709)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	2	NC_051337.1 (20631640..20696388)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	2	NC_005101.4 (18354542..18419077)

Chromosome 2 - NC_086020.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HAPLN1 knockdown inhibits heart failure development via activating the PKA signaling pathway.
Title: HAPLN1 knockdown inhibits heart failure development via activating the PKA signaling pathway.
Hyaluronan and Proteoglycan Link Protein 1 Activates the BMP4/Smad1/5/8 Signaling Pathway to Promote Osteogenic Differentiation: an Implication in Fracture Healing.
Title: Hyaluronan and Proteoglycan Link Protein 1 Activates the BMP4/Smad1/5/8 Signaling Pathway to Promote Osteogenic Differentiation: an Implication in Fracture Healing.
our findings demonstrate that the formation of perineuronal nets triggered by neuronal Crtl1 synthesis is a key event in the diminuation of plasticity in the adult CNS
Title: Animals lacking link protein have attenuated perineuronal nets and persistent plasticity.
HAPLN1 may promote periovulatory granulosa cell survival, which would facilitate their differentiation into luteal cells.
Title: Periovulatory expression of hyaluronan and proteoglycan link protein 1 (Hapln1) in the rat ovary: hormonal regulation and potential function.
study represents the first report that follicle stimulating hormone amplifies insulin-like growth factor-I-mediated cartilage link protein Crtl1 production, possibly via phosphatidylinositol 3-kinase-Akt signaling cascades in rat granulosa cells
Title: Follicle-stimulating hormone and insulin-like growth factor I synergistically induce up-regulation of cartilage link protein (Crtl1) via activation of phosphatidylinositol-dependent kinase/Akt in rat granulosa cells.
Aggrecan, hyaluronan synthases, and, particularly, link protein 1 might be crucial elements for the initial assembly of perineuronal nets.
Title: Upregulation of aggrecan, link protein 1, and hyaluronan synthases during formation of perineuronal nets in the rat cerebellum.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

CRTL1 (e-PCR)
- UniSTS:253966

BE103548 (e-PCR)
- UniSTS:244847

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables hyaluronic acid binding	TAS Traceable Author Statement more info	PubMed
enables structural molecule activity	TAS Traceable Author Statement more info	PubMed

Process	Evidence Code	Pubs
involved_in cell adhesion	IEA Inferred from Electronic Annotation more info
involved_in central nervous system development	IBA Inferred from Biological aspect of Ancestor more info
involved_in skeletal system development	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in extracellular matrix	ISO Inferred from Sequence Orthology more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
is_active_in perineuronal net	IBA Inferred from Biological aspect of Ancestor more info
is_active_in synapse	IBA Inferred from Biological aspect of Ancestor more info
is_active_in synapse	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: hyaluronan and proteoglycan link protein 1

Names: LP; cartilage link protein 1; cartilage-link protein; cartilage-linking protein 1; proteoglycan link protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_019189.2 → NP_062062.2 hyaluronan and proteoglycan link protein 1 precursor

See identical proteins and their annotated locations for NP_062062.2

Status: PROVISIONAL

Source sequence(s)

BC128740

UniProtKB/TrEMBL

A1A5N6, A6I4N0

Related

ENSRNOP00000045959.2, ENSRNOT00000042958.7

Conserved Domains (4) summary

cd05877
Location:53 → 160

Ig_LP_like; Immunoglobulin (Ig)-like domain of human cartilage link protein (LP)

smart00410
Location:54 → 155

IG_like; Immunoglobulin like

cd03518
Location:159 → 253

Link_domain_HAPLN_module_1; Link_domain_HAPLN_module_1; this link domain is found in the first link module of proteins similar to the vertebrate HAPLN (hyaluronan/HA and proteoglycan binding link) protein family which includes cartilage link protein. The link domain is a HA-binding ...

cd03519
Location:260 → 350

Link_domain_HAPLN_module_2; Link_domain_HAPLN_module_2; this link domain is found in the second link module of proteins similar to the vertebrate HAPLN (hyaluronan/HA and proteoglycan binding link) protein family which includes cartilage link protein. The link domain is a ...

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086020.1 Reference GRCr8

Range

22366967..22431709

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006231748.5 → XP_006231810.1 hyaluronan and proteoglycan link protein 1 isoform X1

See identical proteins and their annotated locations for XP_006231810.1

UniProtKB/Swiss-Prot

P03994

UniProtKB/TrEMBL

A6I4N0

Conserved Domains (3) summary

cd03518
Location:159 → 253

Link_domain_HAPLN_module_1; this link domain is found in the first link module of proteins similar to the vertebrate HAPLN (hyaluronan/HA and proteoglycan binding link) protein family which includes cartilage link protein. The link domain is a HA-binding domain. HAPLNs contain two ...

cd03519
Location:260 → 350

Link_domain_HAPLN_module_2; this link domain is found in the second link module of proteins similar to the vertebrate HAPLN (hyaluronan/HA and proteoglycan binding link) protein family which includes cartilage link protein. The link domain is a HA-binding domain. HAPLNs contain two ...

cd05877
Location:43 → 161

Ig_LP_like; Immunoglobulin (Ig)-like domain of human cartilage link protein (LP), and similar domains
XM_039101883.2 → XP_038957811.1 hyaluronan and proteoglycan link protein 1 isoform X1

UniProtKB/Swiss-Prot

P03994

UniProtKB/TrEMBL

A6I4N0

Conserved Domains (3) summary

cd03518
Location:159 → 253

Link_domain_HAPLN_module_1; this link domain is found in the first link module of proteins similar to the vertebrate HAPLN (hyaluronan/HA and proteoglycan binding link) protein family which includes cartilage link protein. The link domain is a HA-binding domain. HAPLNs contain two ...

cd03519
Location:260 → 350

Link_domain_HAPLN_module_2; this link domain is found in the second link module of proteins similar to the vertebrate HAPLN (hyaluronan/HA and proteoglycan binding link) protein family which includes cartilage link protein. The link domain is a HA-binding domain. HAPLNs contain two ...

cd05877
Location:43 → 161

Ig_LP_like; Immunoglobulin (Ig)-like domain of human cartilage link protein (LP), and similar domains