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    Sik1 salt-inducible kinase 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 59329, updated on 9-Dec-2024

    Summary

    Official Symbol
    Sik1provided by RGD
    Official Full Name
    salt-inducible kinase 1provided by RGD
    Primary source
    RGD:69407
    See related
    EnsemblRapid:ENSRNOG00000001189 AllianceGenome:RGD:69407
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Sik; Snf1lk
    Summary
    Enables protein kinase binding activity and protein serine/threonine kinase activity. Involved in negative regulation of transcription by RNA polymerase II; protein phosphorylation; and regulation of sodium ion transport. Predicted to be active in cytoplasm and nucleus. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 30. Orthologous to human SIK1 (salt inducible kinase 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Lung (RPKM 80.3), Spleen (RPKM 72.0) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Sik1 in Genome Data Viewer
    Location:
    20p12
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 20 NC_086038.1 (9947104..9958729, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 20 NC_051355.1 (9949407..9959036, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 20 NC_005119.4 (10670747..10680279, complement)

    Chromosome 20 - NC_086038.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134483882 Neighboring gene uncharacterized LOC134483880 Neighboring gene uncharacterized LOC108349047 Neighboring gene uncharacterized LOC120098851

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    General gene information

    Gene Ontology Provided by RGD

    Items 1 - 25 of 44
    Function Evidence Code Pubs
    enables 14-3-3 protein binding  
    enables 14-3-3 protein binding  
    enables 14-3-3 protein binding  
    enables 3-phosphoinositide-dependent protein kinase activity  
    enables AMP-activated protein kinase activity  
    enables ATP binding  
    enables ATP binding  
    enables ATP binding  
    enables DNA-dependent protein kinase activity  
    enables Rho-dependent protein serine/threonine kinase activity  
    enables cAMP response element binding protein binding  
    enables cAMP response element binding protein binding  
    enables cAMP response element binding protein binding  
    enables eukaryotic translation initiation factor 2alpha kinase activity  
    enables histone H2AS1 kinase activity  
    enables histone H2AS121 kinase activity  
    enables histone H2AT120 kinase activity  
    enables histone H2AXS139 kinase activity  
    enables histone H2BS14 kinase activity  
    enables histone H2BS36 kinase activity  
    enables histone H3S10 kinase activity  
    enables histone H3S28 kinase activity  
    enables histone H3S57 kinase activity  
    enables histone H3T11 kinase activity  
    enables histone H3T3 kinase activity  
    enables histone H3T45 kinase activity  
    enables histone H3T6 kinase activity  
    enables histone H4S1 kinase activity  
    enables histone deacetylase binding  
    enables histone deacetylase binding  
    enables magnesium ion binding  
    enables magnesium ion binding  
    enables magnesium ion binding  
    enables protein binding PubMed 
    enables protein kinase binding  
    enables protein kinase binding PubMed 
    enables protein kinase binding  
    enables protein serine kinase activity  
    enables protein serine/threonine kinase activity  
    enables protein serine/threonine kinase activity PubMed 
    enables protein serine/threonine kinase activity  
    enables protein serine/threonine kinase activity PubMed 
    enables protein serine/threonine kinase activity  
    enables ribosomal protein S6 kinase activity  
    Items 1 - 25 of 44
    Items 1 - 25 of 40
    Process Evidence Code Pubs
    involved_in anoikis  
    involved_in anoikis  
    involved_in cardiac muscle cell differentiation  
    involved_in cardiac muscle cell differentiation  
    involved_in cardiac muscle cell differentiation  
    involved_in chromatin remodeling  
    involved_in entrainment of circadian clock by photoperiod  
    involved_in entrainment of circadian clock by photoperiod  
    involved_in entrainment of circadian clock by photoperiod  
    involved_in intracellular signal transduction  
    involved_in intracellular signal transduction  
    involved_in intracellular signal transduction  
    involved_in intracellular signal transduction  
    involved_in negative regulation of CREB transcription factor activity  
    involved_in negative regulation of CREB transcription factor activity  
    involved_in negative regulation of gluconeogenesis  
    involved_in negative regulation of gluconeogenesis  
    involved_in negative regulation of gluconeogenesis  
    involved_in negative regulation of transcription by RNA polymerase II PubMed 
    involved_in negative regulation of triglyceride biosynthetic process  
    involved_in negative regulation of triglyceride biosynthetic process  
    involved_in negative regulation of triglyceride biosynthetic process  
    involved_in positive regulation of anoikis  
    involved_in positive regulation of anoikis  
    involved_in protein autophosphorylation  
    involved_in protein autophosphorylation  
    involved_in protein phosphorylation PubMed 
    acts_upstream_of_or_within protein phosphorylation  
    involved_in protein phosphorylation  
    involved_in protein phosphorylation  
    involved_in regulation of cell differentiation  
    involved_in regulation of cell differentiation  
    involved_in regulation of mitotic cell cycle  
    involved_in regulation of mitotic cell cycle  
    involved_in regulation of mitotic cell cycle  
    involved_in regulation of myotube differentiation  
    involved_in regulation of myotube differentiation  
    involved_in regulation of myotube differentiation  
    involved_in regulation of sodium ion transport PubMed 
    involved_in rhythmic process  
    Items 1 - 25 of 40
    Component Evidence Code Pubs
    is_active_in cytoplasm  
    located_in cytoplasm  
    located_in cytoplasm  
    located_in cytoplasm  
    is_active_in nucleus  
    located_in nucleus  
    located_in nucleus  
    located_in nucleus  

    General protein information

    Preferred Names
    serine/threonine-protein kinase SIK1
    Names
    SIK-1
    SNF1-like kinase
    protein kinase KID2
    salt-inducible protein kinase 1
    serine/threonine-protein kinase SNF1-like kinase 1
    serine/threonine-protein kinase SNF1LK
    NP_067725.2
    XP_038954976.1
    XP_063135557.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_021693.3NP_067725.2  serine/threonine-protein kinase SIK1

      See identical proteins and their annotated locations for NP_067725.2

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000020
      UniProtKB/Swiss-Prot
      Q9R081, Q9R1U5
      UniProtKB/TrEMBL
      A0A8I6AVK6, A6JK13
      Conserved Domains (2) summary
      cd14408
      Location:300349
      UBA_SIK1; UBA domain found in salt-inducible kinase 1 (SIK1)
      cd14071
      Location:26278
      STKc_SIK; Catalytic domain of the Serine/Threonine Kinases, Salt-Inducible kinases

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086038.1 Reference GRCr8

      Range
      9947104..9958729 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039099048.2XP_038954976.1  serine/threonine-protein kinase SIK1 isoform X1

      UniProtKB/Swiss-Prot
      Q9R081, Q9R1U5
      UniProtKB/TrEMBL
      A0A8I6AVK6, A6JK13
      Related
      ENSRNOP00000001579.3, ENSRNOT00000001579.8
      Conserved Domains (2) summary
      cd14408
      Location:300349
      UBA_SIK1; UBA domain found in salt-inducible kinase 1 (SIK1)
      cd14071
      Location:26278
      STKc_SIK; Catalytic domain of the Serine/Threonine Kinases, Salt-Inducible kinases
    2. XM_063279487.1XP_063135557.1  serine/threonine-protein kinase SIK1 isoform X2

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