Acsbg1 acyl-CoA synthetase bubblegum family member 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Acsbg1provided by RGD
Official Full Name: acyl-CoA synthetase bubblegum family member 1provided by RGD
Primary source: RGD:708557
See related: EnsemblRapid:ENSRNOG00000011381 AllianceGenome:RGD:708557
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Lpd; Grlacs
Summary: Predicted to enable long-chain fatty acid-CoA ligase activity and very long-chain fatty acid-CoA ligase activity. Involved in long-chain fatty acid biosynthetic process and ovarian follicle atresia. Predicted to be located in endoplasmic reticulum and plasma membrane. Predicted to be active in cytoplasm. Human ortholog(s) of this gene implicated in adrenoleukodystrophy. Orthologous to human ACSBG1 (acyl-CoA synthetase bubblegum family member 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Testes (RPKM 344.0) and Brain (RPKM 175.5) See more
Orthologs: human mouse all
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Genomic context

Location:: 8q24

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	8	NC_086026.1 (63887433..63943486, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	8	NC_051343.1 (54991294..55047276, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	8	NC_005107.4 (59184111..59240133, complement)

Chromosome 8 - NC_086026.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

UniSTS:497484 (e-PCR)
- UniSTS:497484

Acsbg1 (e-PCR), detects polymorphism
- UniSTS:497484

RH132425 (e-PCR)
- UniSTS:215708

RH142858 (e-PCR)
- UniSTS:232105

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ligase activity	IEA Inferred from Electronic Annotation more info
enables long-chain fatty acid-CoA ligase activity	IBA Inferred from Biological aspect of Ancestor more info
enables long-chain fatty acid-CoA ligase activity	IEA Inferred from Electronic Annotation more info
enables long-chain fatty acid-CoA ligase activity	ISO Inferred from Sequence Orthology more info
enables long-chain fatty acid-CoA ligase activity	ISS Inferred from Sequence or Structural Similarity more info
enables very long-chain fatty acid-CoA ligase activity	IEA Inferred from Electronic Annotation more info
enables very long-chain fatty acid-CoA ligase activity	ISO Inferred from Sequence Orthology more info
enables very long-chain fatty acid-CoA ligase activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in fatty acid metabolic process	IEA Inferred from Electronic Annotation more info
involved_in lipid biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in long-chain fatty acid biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in long-chain fatty acid biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
involved_in long-chain fatty acid metabolic process	IEA Inferred from Electronic Annotation more info
involved_in long-chain fatty acid metabolic process	ISO Inferred from Sequence Orthology more info
involved_in long-chain fatty acid metabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in ovarian follicle atresia	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to glucocorticoid	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within response to glucocorticoid	ISO Inferred from Sequence Orthology more info
involved_in very long-chain fatty acid metabolic process	IEA Inferred from Electronic Annotation more info
involved_in very long-chain fatty acid metabolic process	ISO Inferred from Sequence Orthology more info
involved_in very long-chain fatty acid metabolic process	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
NOT located_in Golgi apparatus	ISO Inferred from Sequence Orthology more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasmic vesicle	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
NOT located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum	ISS Inferred from Sequence or Structural Similarity more info
NOT located_in peroxisome	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: long-chain-fatty-acid--CoA ligase ACSBG1

Names: gonadotropin-regulated long chain acyl CoA synthetase; lipidosin

NP_599216.1

EC 6.2.1.3

XP_038936682.1

EC 6.2.1.3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_134389.1 → NP_599216.1 long-chain-fatty-acid--CoA ligase ACSBG1

See identical proteins and their annotated locations for NP_599216.1

Status: PROVISIONAL

Source sequence(s)

AF208125

UniProtKB/Swiss-Prot

Q924N5

UniProtKB/TrEMBL

A0A8L2Q8K6

Related

ENSRNOP00000016104.4, ENSRNOT00000016104.6

Conserved Domains (1) summary

cd05933
Location:122 → 716

ACSBG_like; Bubblegum-like very long-chain fatty acid CoA synthetase (VL-FACS)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086026.1 Reference GRCr8

Range

63887433..63943486 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039080754.2 → XP_038936682.1 long-chain-fatty-acid--CoA ligase ACSBG1 isoform X1

UniProtKB/TrEMBL

A0A8I5ZUY7, A0A8L2Q8K6

Related

ENSRNOP00000082463.1, ENSRNOT00000098670.2

Conserved Domains (1) summary

cl17068
Location:163 → 698

AFD_class_I; Adenylate forming domain, Class I superfamily