Thrap3 thyroid hormone receptor associated protein 3 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Thrap3provided by MGI
Official Full Name: thyroid hormone receptor associated protein 3provided by MGI
Primary source: MGI:MGI:2442637
See related: Ensembl:ENSMUSG00000043962 AllianceGenome:MGI:2442637
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Trap150; 9330151F09Rik; B230333E16Rik
Summary: Enables RNA polymerase II cis-regulatory region sequence-specific DNA binding activity and transcription coactivator activity. Involved in circadian rhythm. Part of mediator complex. Is expressed in several structures, including brain; branchial arch; genitourinary system; limb; and retina nuclear layer. Orthologous to human THRAP3 (thyroid hormone receptor associated protein 3). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Ubiquitous expression in CNS E11.5 (RPKM 45.1), limb E14.5 (RPKM 31.5) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 4 D2.2; 4 60.0 cM

Exon count:: 16

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	4	NC_000070.7 (126057875..126096548, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	4	NC_000070.6 (126164082..126202755, complement)

Chromosome 4 - NC_000070.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

LncRNA RP4-639F20.1 interacts with THRAP3 to attenuate atherosclerosis by regulating c-FOS in vascular smooth muscle cells proliferation and migration.
Title: LncRNA RP4-639F20.1 interacts with THRAP3 to attenuate atherosclerosis by regulating c-FOS in vascular smooth muscle cells proliferation and migration.
Thrap3 promotes nonalcoholic fatty liver disease by suppressing AMPK-mediated autophagy.
Title: Thrap3 promotes nonalcoholic fatty liver disease by suppressing AMPK-mediated autophagy.
These results indicate that THRAP3 negatively regulates SOX9 transcriptional activity as a cofactor of a SOX9 transcriptional complex during chondrogenesis.
Title: THRAP3 interacts with and inhibits the transcriptional activity of SOX9 during chondrogenesis.
Thrap3 could play indispensable roles in terminal differentiation of adipocytes by enhancing PPARgamma-mediated gene activation cooperatively with Helz2.
Title: THRAP3 interacts with HELZ2 and plays a novel role in adipocyte differentiation.
TRAP150 is a selective coactivator for CLOCK-BMAL1, promoting its binding to target genes and linking it to the transcriptional machinery at target-gene promoters.
Title: A positive feedback loop links circadian clock factor CLOCK-BMAL1 to the basic transcriptional machinery.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3)
Targeted (2) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables nuclear thyroid hormone receptor binding	IEA Inferred from Electronic Annotation more info
enables nuclear thyroid hormone receptor binding	ISO Inferred from Sequence Orthology more info
enables phosphoprotein binding	ISO Inferred from Sequence Orthology more info
enables phosphoprotein binding	ISS Inferred from Sequence or Structural Similarity more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables transcription coactivator activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables transcription coactivator activity	ISO Inferred from Sequence Orthology more info
enables transcription coregulator activity	IBA Inferred from Biological aspect of Ancestor more info
enables transcription coregulator activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in RNA splicing	IEA Inferred from Electronic Annotation more info
involved_in circadian rhythm	IEP Inferred from Expression Pattern more info	PubMed
involved_in mRNA processing	IEA Inferred from Electronic Annotation more info
involved_in mRNA stabilization	ISO Inferred from Sequence Orthology more info
involved_in mRNA stabilization	ISS Inferred from Sequence or Structural Similarity more info
involved_in nuclear-transcribed mRNA catabolic process	ISO Inferred from Sequence Orthology more info
involved_in nuclear-transcribed mRNA catabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of circadian rhythm	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of circadian rhythm	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of mRNA splicing, via spliceosome	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of mRNA splicing, via spliceosome	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in regulation of alternative mRNA splicing, via spliceosome	ISO Inferred from Sequence Orthology more info
involved_in regulation of alternative mRNA splicing, via spliceosome	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within transcription by RNA polymerase II	IC Inferred by Curator more info	PubMed

Component	Evidence Code	Pubs
part_of exon-exon junction complex	ISO Inferred from Sequence Orthology more info
part_of exon-exon junction complex	ISS Inferred from Sequence or Structural Similarity more info
part_of mediator complex	IBA Inferred from Biological aspect of Ancestor more info
part_of mediator complex	IDA Inferred from Direct Assay more info	PubMed
part_of mediator complex	ISO Inferred from Sequence Orthology more info
located_in nuclear speck	ISO Inferred from Sequence Orthology more info
located_in nuclear speck	ISS Inferred from Sequence or Structural Similarity more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	TAS Traceable Author Statement more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: thyroid hormone receptor-associated protein 3

Names: thyroid hormone receptor-associated protein complex 150 kDa component

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001356455.1 → NP_001343384.1 thyroid hormone receptor-associated protein 3

Status: VALIDATED

Source sequence(s)

AL732624, BB855884, BC092239

Consensus CDS

CCDS18645.1

UniProtKB/Swiss-Prot

Q569Z6

Conserved Domains (1) summary

pfam15440
Location:191 → 766

THRAP3_BCLAF1; THRAP3/BCLAF1 family
NM_001356456.1 → NP_001343385.1 thyroid hormone receptor-associated protein 3

Status: VALIDATED

Source sequence(s)

AL732624, BB855884, BC092239

Consensus CDS

CCDS18645.1

UniProtKB/Swiss-Prot

Q569Z6

Conserved Domains (1) summary

pfam15440
Location:191 → 766

THRAP3_BCLAF1; THRAP3/BCLAF1 family
NM_146153.3 → NP_666265.3 thyroid hormone receptor-associated protein 3

See identical proteins and their annotated locations for NP_666265.3

Status: VALIDATED

Source sequence(s)

BC092239, BY327148

Consensus CDS

CCDS18645.1

UniProtKB/Swiss-Prot

Q569Z6

Related

ENSMUSP00000079722.6, ENSMUST00000080919.12

Conserved Domains (1) summary

pfam15440
Location:191 → 766

THRAP3_BCLAF1; THRAP3/BCLAF1 family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000070.7 Reference GRCm39 C57BL/6J

Range

126057875..126096548 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036164049.1 → XP_036019942.1 thyroid hormone receptor-associated protein 3 isoform X2

Conserved Domains (1) summary

pfam15440
Location:3 → 484

THRAP3_BCLAF1; THRAP3/BCLAF1 family
XM_036164048.1 → XP_036019941.1 thyroid hormone receptor-associated protein 3 isoform X2

Conserved Domains (1) summary

pfam15440
Location:3 → 484

THRAP3_BCLAF1; THRAP3/BCLAF1 family
XM_036164047.1 → XP_036019940.1 thyroid hormone receptor-associated protein 3 isoform X1

UniProtKB/Swiss-Prot

Q569Z6

Conserved Domains (1) summary

pfam15440
Location:191 → 766

THRAP3_BCLAF1; THRAP3/BCLAF1 family