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    Rbm44 RNA binding motif protein 44 [ Mus musculus (house mouse) ]

    Gene ID: 329207, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Rbm44provided by MGI
    Official Full Name
    RNA binding motif protein 44provided by MGI
    Primary source
    MGI:MGI:2685663
    See related
    Ensembl:ENSMUSG00000070732 AllianceGenome:MGI:2685663
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Gm817
    Summary
    Enables protein homodimerization activity. Predicted to be involved in mRNA splicing, via spliceosome. Located in cytoplasm and intercellular bridge. Orthologous to human RBM44 (RNA binding motif protein 44). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in testis adult (RPKM 5.5), liver E14 (RPKM 0.5) and 2 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Rbm44 in Genome Data Viewer
    Location:
    1 D; 1 46.08 cM
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (91072695..91098521)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (91144973..91170799)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene RAB17, member RAS oncogene family Neighboring gene leucine rich repeat (in FLII) interacting protein 1 Neighboring gene STARR-positive B cell enhancer ABC_E4334 Neighboring gene STARR-positive B cell enhancer ABC_E3290 Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:92961823-92961976 Neighboring gene predicted gene, 35443 Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:93080001-93080198 Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:93089975-93090287 Neighboring gene proteasome (prosome, macropain) 28 subunit, alpha pseudogene Neighboring gene receptor (calcitonin) activity modifying protein 1 Neighboring gene STARR-positive B cell enhancer ABC_E9471

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Identification and characterization of RBM44 as a novel intercellular bridge protein. Iwamori T, et al. PLoS One, 2011 Feb 25. PMID 21364893, Free PMC Article
    2. E2F6 initiates stable epigenetic silencing of germline genes during embryonic development. Dahlet T, et al. Nat Commun, 2021 Jun 11. PMID 34117224, Free PMC Article
    3. Fancd2 in vivo interaction network reveals a non-canonical role in mitochondrial function. Zhang T, et al. Sci Rep, 2017 Apr 5. PMID 28378742, Free PMC Article
    4. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
    5. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables mRNA 3'-UTR binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein homodimerization activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in mRNA splicing, via spliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of catalytic step 2 spliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in intercellular bridge IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    RNA-binding protein 44

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001033408.5 → NP_001028580.1  RNA-binding protein 44

      See identical proteins and their annotated locations for NP_001028580.1

      Status: VALIDATED

      Source sequence(s)
      AC162883
      Consensus CDS
      CCDS15157.1
      UniProtKB/Swiss-Prot
      Q3V089
      UniProtKB/TrEMBL
      B9EKJ9
      Related
      ENSMUSP00000092286.2, ENSMUST00000094698.2
      Conserved Domains (1) summary
      cd12248
      Location:793 → 865
      RRM_RBM44; RNA recognition motif in RNA-binding protein 44 (RBM44) and similar proteins

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      91072695..91098521
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006529704.1 → XP_006529767.1  RNA-binding protein 44 isoform X2

    2. XM_006529702.1 → XP_006529765.1  RNA-binding protein 44 isoform X1

      See identical proteins and their annotated locations for XP_006529765.1

      UniProtKB/Swiss-Prot
      Q3V089
      UniProtKB/TrEMBL
      B9EKJ9
      Conserved Domains (1) summary
      cd12248
      Location:793 → 865
      RRM_RBM44; RNA recognition motif in RNA-binding protein 44 (RBM44) and similar proteins
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q3V089.1 GenPept UniProtKB/Swiss-Prot:Q3V089

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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