Pwwp2a PWWP domain containing 2A [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Pwwp2aprovided by MGI
Official Full Name: PWWP domain containing 2Aprovided by MGI
Primary source: MGI:MGI:1918052
See related: Ensembl:ENSMUSG00000044950 AllianceGenome:MGI:1918052
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 4631424J17Rik; D930040F23Rik
Summary: Predicted to enable NuRD complex binding activity; chromatin binding activity; and methylated histone binding activity. Involved in chromatin remodeling; positive regulation of transcription elongation by RNA polymerase II; and regulation of transcriptional start site selection at RNA polymerase II promoter. Predicted to be active in nucleus. Orthologous to human PWWP2A (PWWP domain containing 2A). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Ubiquitous expression in CNS E11.5 (RPKM 2.8), CNS E14 (RPKM 2.3) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 11 B1.1; 11 25.81 cM

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	11	NC_000077.7 (43566881..43613248)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	11	NC_000077.6 (43681125..43722633)

Chromosome 11 - NC_000077.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Study in HeLa, HEK293F, and mouse embryonic stem cells reveal that loss of PWWP2A/B leads to increases in histone acetylation predominantly at highly expressed genes, accompanied by decreases in Pol II elongation. Collectively, these findings suggest a role for PWWP2A/B in regulating transcription through the fine-tuning of histone acetylation dynamics at actively transcribed genes.
Title: A variant NuRD complex containing PWWP2A/B excludes MBD2/3 to regulate transcription at active genes.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)

General gene information

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Markers

NoName (e-PCR)
- UniSTS:236558

UniSTS:236559 (e-PCR)
- UniSTS:236559

AI891583 (e-PCR)
- UniSTS:180178

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables NuRD complex binding	ISO Inferred from Sequence Orthology more info
enables NuRD complex binding	ISS Inferred from Sequence or Structural Similarity more info
enables chromatin binding	IBA Inferred from Biological aspect of Ancestor more info
enables chromatin binding	ISO Inferred from Sequence Orthology more info
enables chromatin binding	ISS Inferred from Sequence or Structural Similarity more info
enables histone binding	IBA Inferred from Biological aspect of Ancestor more info
enables histone binding	ISO Inferred from Sequence Orthology more info
enables methylated histone binding	ISO Inferred from Sequence Orthology more info
enables methylated histone binding	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in chromatin remodeling	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in chromatin remodeling	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transcription elongation by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of transcriptional start site selection at RNA polymerase II promoter	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: PWWP domain-containing protein 2A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001164231.2 → NP_001157703.1 PWWP domain-containing protein 2A isoform a

Status: VALIDATED

Source sequence(s)

AL732633

Consensus CDS

CCDS48773.1

UniProtKB/Swiss-Prot

Q69Z61

Related

ENSMUSP00000091852.5, ENSMUST00000094294.5
NM_001363141.2 → NP_001350070.1 PWWP domain-containing protein 2A isoform 3

Status: VALIDATED

Source sequence(s)

AL732633
NM_001363142.2 → NP_001350071.1 PWWP domain-containing protein 2A isoform 4

Status: VALIDATED

Source sequence(s)

AL732633
NM_027557.2 → NP_081833.1 PWWP domain-containing protein 2A isoform b

See identical proteins and their annotated locations for NP_081833.1

Status: VALIDATED

Source sequence(s)

AL732633

Consensus CDS

CCDS48774.1

UniProtKB/Swiss-Prot

A2AJK9, A2AJL0, Q3TBG3, Q69Z61, Q9CUT9

Related

ENSMUSP00000054154.6, ENSMUST00000061070.6

Conserved Domains (1) summary

cd05835
Location:628 → 714

Dnmt3b_related; The PWWP domain is an essential component of DNA methyltransferase 3 B (Dnmt3b) which is responsible for establishing DNA methylation patterns during embryogenesis and gametogenesis. In tumorigenesis, DNA methylation by Dnmt3b is known to play a role in ...