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    Sh3d21 SH3 domain containing 21 [ Mus musculus (house mouse) ]

    Gene ID: 66938, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Sh3d21provided by MGI
    Official Full Name
    SH3 domain containing 21provided by MGI
    Primary source
    MGI:MGI:1914188
    See related
    Ensembl:ENSMUSG00000073758 AllianceGenome:MGI:1914188
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    1700029G01Rik
    Summary
    Predicted to be involved in actin filament organization and cell migration. Predicted to be located in nucleoplasm and plasma membrane. Orthologous to human SH3D21 (SH3 domain containing 21). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in testis adult (RPKM 90.1) and colon adult (RPKM 8.7) See more
    Orthologs
    human all
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    Genomic context

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    See Sh3d21 in Genome Data Viewer
    Location:
    4 D2.2; 4 59.97 cM
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (126044395..126057503, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (126150602..126163518, complement)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E2713 Neighboring gene serine/threonine kinase 40 Neighboring gene eva-1 homolog B Neighboring gene CapStarr-seq enhancer MGSCv37_chr4:125839584-125839767 Neighboring gene STARR-seq mESC enhancer starr_11390 Neighboring gene thyroid hormone receptor associated protein 3 Neighboring gene STARR-seq mESC enhancer starr_11391 Neighboring gene STARR-seq mESC enhancer starr_11392 Neighboring gene predicted gene, 25323 Neighboring gene MAP7 domain containing 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Gene-deficient mouse model established by CRISPR/Cas9 system reveals 15 reproductive organ-enriched genes dispensable for male fertility. Nguyen TTT, et al. Front Cell Dev Biol, 2024. PMID 38835510, Free PMC Article
    2. The Rodent-Specific MicroRNA Cluster within the Sfmbt2 Gene Is Imprinted and Essential for Placental Development. Inoue K, et al. Cell Rep, 2017 May 2. PMID 28467908
    3. Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Ko MS, et al. Development, 2000 Apr. PMID 10725249
    4. BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain. Pourhaghighi R, et al. Cell Syst, 2020 Apr 22. PMID 32325033, Free PMC Article
    5. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in actin filament organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cell migration IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    SH3 domain-containing protein 21
    Names
    SH3 domain-containing protein C1orf113 homolog

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001162533.1 → NP_001156005.1  SH3 domain-containing protein 21 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AL731780
      Consensus CDS
      CCDS51301.1
      UniProtKB/TrEMBL
      Z4YK11
      Related
      ENSMUSP00000095501.4, ENSMUST00000097891.4
      Conserved Domains (3) summary
      cd11874
      Location:87 → 139
      SH3_CD2AP-like_2; Second Src Homology 3 domain (SH3B) of CD2-associated protein and similar proteins
      cd12142
      Location:186 → 239
      SH3_D21-like; Src Homology 3 domain of SH3 domain-containing protein 21 (SH3D21) and similar proteins
      cl17036
      Location:2 → 55
      SH3; Src Homology 3 domain superfamily

    2. NM_025856.3 → NP_080132.1  SH3 domain-containing protein 21 isoform 2

      See identical proteins and their annotated locations for NP_080132.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) represents use of an alternate promoter and 5' UTR, uses a downstream start codon, and lacks an alternate exon, compared to variant 1. The resulting isoform (2) has a shorter and distinct N-terminus, compared to isoform 1.
      Source sequence(s)
      AK011430, AK076962, AL731780, BF452472
      Consensus CDS
      CCDS18644.1
      UniProtKB/Swiss-Prot
      B1AW04, Q3U2S3, Q7TSG5
      Related
      ENSMUSP00000092352.3, ENSMUST00000094760.9
      Conserved Domains (2) summary
      PTZ00449
      Location:144 → 475
      PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
      cd12142
      Location:70 → 123
      SH3_D21-like; Src Homology 3 domain of SH3 domain-containing protein 21 (SH3D21) and similar proteins

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      126044395..126057503 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030253709.2 → XP_030109569.1  SH3 domain-containing protein 21 isoform X3

      Conserved Domains (3) summary
      PTZ00449
      Location:232 → 563
      PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
      cd11874
      Location:59 → 111
      SH3_CD2AP-like_2; Second Src Homology 3 domain (SH3B) of CD2-associated protein and similar proteins
      cd12142
      Location:158 → 211
      SH3_D21-like; Src Homology 3 domain of SH3 domain-containing protein 21 (SH3D21) and similar proteins

    2. XM_036164353.1 → XP_036020246.1  SH3 domain-containing protein 21 isoform X6

    3. XM_030253708.2 → XP_030109568.1  SH3 domain-containing protein 21 isoform X2

      Conserved Domains (3) summary
      PTZ00449
      Location:233 → 564
      PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
      cd11874
      Location:60 → 112
      SH3_CD2AP-like_2; Second Src Homology 3 domain (SH3B) of CD2-associated protein and similar proteins
      cd12142
      Location:159 → 212
      SH3_D21-like; Src Homology 3 domain of SH3 domain-containing protein 21 (SH3D21) and similar proteins

    4. XM_030253707.2 → XP_030109567.1  SH3 domain-containing protein 21 isoform X1

      Conserved Domains (4) summary
      PTZ00449
      Location:259 → 590
      PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
      cd11874
      Location:86 → 138
      SH3_CD2AP-like_2; Second Src Homology 3 domain (SH3B) of CD2-associated protein and similar proteins
      cd12142
      Location:185 → 238
      SH3_D21-like; Src Homology 3 domain of SH3 domain-containing protein 21 (SH3D21) and similar proteins
      cl17036
      Location:2 → 55
      SH3; Src Homology 3 domain superfamily

    5. XM_030253710.2 → XP_030109570.1  SH3 domain-containing protein 21 isoform X4

      Conserved Domains (4) summary
      PTZ00449
      Location:260 → 591
      PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
      cd11874
      Location:87 → 139
      SH3_CD2AP-like_2; Second Src Homology 3 domain (SH3B) of CD2-associated protein and similar proteins
      cd12142
      Location:186 → 239
      SH3_D21-like; Src Homology 3 domain of SH3 domain-containing protein 21 (SH3D21) and similar proteins
      cl17036
      Location:2 → 55
      SH3; Src Homology 3 domain superfamily

    6. XM_036164354.1 → XP_036020247.1  SH3 domain-containing protein 21 isoform X6

      Conserved Domains (1) summary
      PHA03247
      Location:37 → 359
      PHA03247; large tegument protein UL36; Provisional

    7. XM_030253711.2 → XP_030109571.1  SH3 domain-containing protein 21 isoform X5

      UniProtKB/Swiss-Prot
      B1AW04, Q3U2S3, Q7TSG5
      Conserved Domains (2) summary
      PTZ00449
      Location:144 → 475
      PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
      cd12142
      Location:70 → 123
      SH3_D21-like; Src Homology 3 domain of SH3 domain-containing protein 21 (SH3D21) and similar proteins
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7TSG5.1 GenPept UniProtKB/Swiss-Prot:Q7TSG5

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    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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