Klra21 killer cell lectin-like receptor subfamily A, member 21 [Mus musculus (house mouse)] - Gene

Summary

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Official Symbol: Klra21provided by MGI
Official Full Name: killer cell lectin-like receptor subfamily A, member 21provided by MGI
Primary source: MGI:MGI:2136938
See related: AllianceGenome:MGI:2136938
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Ly49H; Ly49u; Klra-ps1
Summary: Predicted to be located in plasma membrane. [provided by Alliance of Genome Resources, Dec 2024]
Annotation information: not in current annotation release
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Genomic context

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See Klra21 in Genome Data Viewer

Location:: 6; 6 F3

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

A recombinant murine cytomegalovirus in which m157(K181) is replaced with m157(G1F), which interacts with both Ly49H and Ly49C, causes no apparent attenuating effect on viral clearance from natural killer (NK) cells.
Title: Functional consequences of natural sequence variation of murine cytomegalovirus m157 for Ly49 receptor specificity and NK cell activation.
Signaling through the natural killer (NK) cell activation receptor Ly49H is able to compensate for the absence of cytokine stimulation in the preferential phase of viral-induced proliferation during murine cytomegalovirus infection.
Title: Ly49H engagement compensates for the absence of type I interferon signaling in stimulating NK cell proliferation during murine cytomegalovirus infection.

Submit: New GeneRIF Correction

General gene information

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Markers

NoName (e-PCR)
- UniSTS:488991

NoName (e-PCR)
- UniSTS:488020

Klra3 (e-PCR), detects polymorphism
- UniSTS:143711

Klra8 (e-PCR), detects polymorphism
- UniSTS:143718

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables molecular_function	ND No biological Data available more info

Process	Evidence Code	Pubs
involved_in biological_process	ND No biological Data available more info

Component	Evidence Code	Pubs
located_in plasma membrane	TAS Traceable Author Statement more info	PubMed

General protein information

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Preferred Names: killer cell lectin-like receptor subfamily A, member 21

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_053151.1 → NP_444381.1 killer cell lectin-like receptor subfamily A, member 21

See identical proteins and their annotated locations for NP_444381.1

Status: PROVISIONAL

Source sequence(s)

AF288380

UniProtKB/TrEMBL

Q4Z8P5, Q9JHV1

Conserved Domains (2) summary

cd03593
Location:145 → 259

CLECT_NK_receptors_like; C-type lectin-like domain (CTLD) of the type found in natural killer cell receptors (NKRs)

pfam08391
Location:40 → 157

Ly49; Ly49-like protein, N-terminal region