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    Dach2 dachshund family transcription factor 2 [ Mus musculus (house mouse) ]

    Gene ID: 93837, updated on 27-Nov-2024

    Summary

    Official Symbol
    Dach2provided by MGI
    Official Full Name
    dachshund family transcription factor 2provided by MGI
    Primary source
    MGI:MGI:1890446
    See related
    Ensembl:ENSMUSG00000025592 AllianceGenome:MGI:1890446
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    9430028N04Rik
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within development of primary female sexual characteristics. Predicted to be part of transcription regulator complex. Predicted to be active in nucleus. Is expressed in several structures, including central nervous system; embryo mesenchyme; genitourinary system; gut; and sensory organ. Orthologous to human DACH2 (dachshund family transcription factor 2). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Low expression observed in reference dataset See more
    Orthologs
    NEW
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    Genomic context

    See Dach2 in Genome Data Viewer
    Location:
    X E1; X 49.13 cM
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (112207177..112746083)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (113297496..113836386)

    Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene microRNA 361 Neighboring gene CHM Rab escort protein Neighboring gene STARR-seq mESC enhancer starr_47784 Neighboring gene STARR-seq mESC enhancer starr_47785 Neighboring gene STARR-seq mESC enhancer starr_47786 Neighboring gene Ras-GTPase-activating protein SH3-domain binding protein 1 pseudogene Neighboring gene STARR-seq mESC enhancer starr_47787 Neighboring gene predicted gene, 24831 Neighboring gene STARR-seq mESC enhancer starr_47789 Neighboring gene STARR-seq mESC enhancer starr_47790 Neighboring gene predicted gene, 23985 Neighboring gene STARR-seq mESC enhancer starr_47791 Neighboring gene STARR-seq mESC enhancer starr_47792 Neighboring gene pyruvate kinase, muscle pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Targeted (2)  1 citation

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Process Evidence Code Pubs
    acts_upstream_of_or_within development of primary female sexual characteristics IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    part_of transcription regulator complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    dachshund homolog 2
    Names
    Dach2fiveprime
    Dach2threeprime
    dachshund 2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001142570.1NP_001136042.1  dachshund homolog 2 isoform 1

      See identical proteins and their annotated locations for NP_001136042.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes isoform 1.
      Source sequence(s)
      AK020442, AK045154, BB175077, BC059233
      Consensus CDS
      CCDS53175.1
      UniProtKB/Swiss-Prot
      Q925Q8
      Related
      ENSMUSP00000109009.2, ENSMUST00000113382.8
      Conserved Domains (1) summary
      pfam02437
      Location:69168
      Ski_Sno; SKI/SNO/DAC family
    2. NM_001289732.1NP_001276661.1  dachshund homolog 2 isoform 3

      See identical proteins and their annotated locations for NP_001276661.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) has multiple differences, compared to variant 1. These differences result in a distinct 5' UTR and cause translation initiation at an alternate start codon, compared to variant 1. The encoded protein (isoform 3) is shorter and has a distinct N- and C-terminus, compared to isoform 1.
      Source sequence(s)
      AK033050, AK041446
      Consensus CDS
      CCDS81163.1
      UniProtKB/Swiss-Prot
      Q925Q8
      Related
      ENSMUSP00000109007.2, ENSMUST00000113380.8
    3. NM_001289733.1NP_001276662.1  dachshund homolog 2 isoform 4

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) has multiple differences, compared to variant 1. These differences result in a distinct 5' UTR and cause translation initiation at an alternate start codon, compared to variant 1. The encoded protein (isoform 4) is shorter and has a distinct N-terminus, compared to isoform 1.
      Source sequence(s)
      AK020442, AK033050, AK038687, AK041446, BC059233
      Consensus CDS
      CCDS81164.1
      UniProtKB/TrEMBL
      B1AU60
      Related
      ENSMUSP00000109006.2, ENSMUST00000113379.8
    4. NM_001289734.1NP_001276663.1  dachshund homolog 2 isoform 5

      See identical proteins and their annotated locations for NP_001276663.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) has multiple differences, compared to variant 1. These differences result in a distinct 5' UTR and cause translation initiation at an alternate start codon, compared to variant 1. The encoded protein (isoform 5) is shorter and has a distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AK033050, AK041446, AK042401
      Consensus CDS
      CCDS81165.1
      UniProtKB/TrEMBL
      B1AXA6
      Related
      ENSMUSP00000109005.2, ENSMUST00000113378.8
    5. NM_033605.2NP_291083.1  dachshund homolog 2 isoform 2

      See identical proteins and their annotated locations for NP_291083.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame segment in the 5' coding region and uses a different segment for its 3' coding region and UTR, compared to variant 1. The resulting protein (isoform 2) has a shorter and distinct C-terminus when it is compared to isoform 1.
      Source sequence(s)
      AK041446, AK045154, AL672062
      Consensus CDS
      CCDS30363.1
      UniProtKB/Swiss-Prot
      Q8BMA0, Q925Q8
      Related
      ENSMUSP00000064393.5, ENSMUST00000067219.5
      Conserved Domains (1) summary
      pfam02437
      Location:69168
      Ski_Sno; SKI/SNO/DAC family

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000086.8 Reference GRCm39 C57BL/6J

      Range
      112207177..112746083
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030251527.2XP_030107387.1  dachshund homolog 2 isoform X10

      Conserved Domains (1) summary
      pfam02437
      Location:28127
      Ski_Sno; SKI/SNO/DAC family
    2. XM_011247714.2XP_011246016.1  dachshund homolog 2 isoform X9

      See identical proteins and their annotated locations for XP_011246016.1

      Conserved Domains (1) summary
      pfam02437
      Location:28127
      Ski_Sno; SKI/SNO/DAC family
    3. XM_011247713.4XP_011246015.1  dachshund homolog 2 isoform X4

      Conserved Domains (1) summary
      pfam02437
      Location:69168
      Ski_Sno; SKI/SNO/DAC family
    4. XM_030251523.2XP_030107383.1  dachshund homolog 2 isoform X1

      Conserved Domains (1) summary
      pfam02437
      Location:69168
      Ski_Sno; SKI/SNO/DAC family
    5. XM_030251524.2XP_030107384.1  dachshund homolog 2 isoform X6

      Conserved Domains (1) summary
      pfam02437
      Location:69168
      Ski_Sno; SKI/SNO/DAC family
    6. XM_011247711.4XP_011246013.1  dachshund homolog 2 isoform X2

      Conserved Domains (1) summary
      pfam02437
      Location:69168
      Ski_Sno; SKI/SNO/DAC family
    7. XM_030251525.2XP_030107385.1  dachshund homolog 2 isoform X7

      Conserved Domains (2) summary
      pfam02437
      Location:69168
      Ski_Sno; SKI/SNO/DAC family
      pfam09731
      Location:355597
      Mitofilin; Mitochondrial inner membrane protein
    8. XM_030251528.2XP_030107388.1  dachshund homolog 2 isoform X12

      Conserved Domains (1) summary
      pfam02437
      Location:69168
      Ski_Sno; SKI/SNO/DAC family
    9. XM_030251526.2XP_030107386.1  dachshund homolog 2 isoform X8

      UniProtKB/Swiss-Prot
      Q8BMA0, Q925Q8
      Conserved Domains (1) summary
      pfam02437
      Location:69168
      Ski_Sno; SKI/SNO/DAC family
    10. XM_036162128.1XP_036018021.1  dachshund homolog 2 isoform X18

    11. XM_011247716.3XP_011246018.1  dachshund homolog 2 isoform X13

      See identical proteins and their annotated locations for XP_011246018.1

      UniProtKB/Swiss-Prot
      Q925Q8
    12. XM_036162124.1XP_036018017.1  dachshund homolog 2 isoform X15

      UniProtKB/TrEMBL
      B1AXA6
    13. XM_036162127.1XP_036018020.1  dachshund homolog 2 isoform X17

    14. XM_036162126.1XP_036018019.1  dachshund homolog 2 isoform X16

    15. XM_011247715.1XP_011246017.1  dachshund homolog 2 isoform X9

      See identical proteins and their annotated locations for XP_011246017.1

      Conserved Domains (1) summary
      pfam02437
      Location:28127
      Ski_Sno; SKI/SNO/DAC family
    16. XM_036162125.1XP_036018018.1  dachshund homolog 2 isoform X15

      UniProtKB/TrEMBL
      B1AXA6
    17. XM_030251529.2XP_030107389.1  dachshund homolog 2 isoform X14

    18. XM_011247712.3XP_011246014.1  dachshund homolog 2 isoform X3

      Conserved Domains (1) summary
      pfam02437
      Location:69168
      Ski_Sno; SKI/SNO/DAC family
    19. XM_036162123.1XP_036018016.1  dachshund homolog 2 isoform X5

      Conserved Domains (1) summary
      cd21081
      Location:73167
      DHD_Dac; Dachshund-homology domain found in the retinal determination protein Dachshund and similar proteins
    20. XM_006528416.4XP_006528479.1  dachshund homolog 2 isoform X11

      Conserved Domains (2) summary
      pfam01576
      Location:474571
      Myosin_tail_1; Myosin tail
      pfam02437
      Location:69168
      Ski_Sno; SKI/SNO/DAC family