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    Slc25a51 solute carrier family 25, member 51 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 313241, updated on 27-Dec-2024

    Summary

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    Official Symbol
    Slc25a51provided by RGD
    Official Full Name
    solute carrier family 25, member 51provided by RGD
    Primary source
    RGD:1305190
    See related
    EnsemblRapid:ENSRNOG00000039278 AllianceGenome:RGD:1305190
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Mcart1
    Summary
    Predicted to enable NAD transmembrane transporter activity. Predicted to be involved in aerobic electron transport chain and mitochondrial NAD transmembrane transport. Predicted to be active in mitochondrial inner membrane. Orthologous to human SLC25A51 (solute carrier family 25 member 51) and SLC25A52 (solute carrier family 25 member 52). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Kidney (RPKM 317.7), Adrenal (RPKM 210.2) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Slc25a51 in Genome Data Viewer
    Location:
    5q22
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (64445610..64459172, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (59649980..59663454, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (60942566..60956135, complement)

    Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene phosphoglycerate mutase 1, pseudogene 8 Neighboring gene DDB1 and CUL4 associated factor 10 like Neighboring gene DDB1 and CUL4 associated factor 10 Neighboring gene SH2 domain containing adaptor protein B Neighboring gene uncharacterized LOC103692348

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article
    2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables NAD transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables NAD transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables NAD transmembrane transporter activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of aerobic electron transport chain ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in aerobic electron transport chain ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in aerobic electron transport chain ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in mitochondrial NAD transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitochondrial NAD transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in mitochondrial NAD transmembrane transport ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in mitochondrial inner membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in mitochondrial inner membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in mitochondrial inner membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrion ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    mitochondrial nicotinamide adenine dinucleotide transporter SLC25A51
    Names
    mitochondrial NAD(+) transporter SLC25A51
    mitochondrial carrier triple repeat 1
    mitochondrial carrier triple repeat protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001024785.3 → NP_001019956.1  mitochondrial nicotinamide adenine dinucleotide transporter SLC25A51

      See identical proteins and their annotated locations for NP_001019956.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000005
      UniProtKB/Swiss-Prot
      Q52KK3
      UniProtKB/TrEMBL
      A0A8I5YBE2, A6IJ96
      Related
      ENSRNOP00000056892.2, ENSRNOT00000060149.6
      Conserved Domains (1) summary
      pfam00153
      Location:31 → 112
      Mito_carr; Mitochondrial carrier protein

    2. NM_001394297.1 → NP_001381226.1  mitochondrial nicotinamide adenine dinucleotide transporter SLC25A51

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000005
      UniProtKB/Swiss-Prot
      Q52KK3
      UniProtKB/TrEMBL
      A0A8I5YBE2, A6IJ96
      Related
      ENSRNOP00000065025.1, ENSRNOT00000071116.4
      Conserved Domains (1) summary
      pfam00153
      Location:31 → 112
      Mito_carr; Mitochondrial carrier protein

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086023.1 Reference GRCr8

      Range
      64445610..64459172 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006238065.5 → XP_006238127.1  mitochondrial nicotinamide adenine dinucleotide transporter SLC25A51 isoform X1

      See identical proteins and their annotated locations for XP_006238127.1

      UniProtKB/Swiss-Prot
      Q52KK3
      UniProtKB/TrEMBL
      A0A8I5YBE2, A6IJ96
      Conserved Domains (1) summary
      pfam00153
      Location:31 → 112
      Mito_carr; Mitochondrial carrier protein

    2. XM_063287630.1 → XP_063143700.1  mitochondrial nicotinamide adenine dinucleotide transporter SLC25A51 isoform X1

      UniProtKB/Swiss-Prot
      Q52KK3
      UniProtKB/TrEMBL
      A0A8I5YBE2, A6IJ96
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q52KK3.1 GenPept UniProtKB/Swiss-Prot:Q52KK3

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials