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    CG8176 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 261329, updated on 17-Dec-2024

    Summary

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    Official Symbol
    CG8176provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0037702
    Locus tag
    Dmel_CG8176
    See related
    AllianceGenome:FB:FBgn0037702
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG31123; Dmel\CG8176; FCHo; FCHo2
    Summary
    Predicted to enable AP-2 adaptor complex binding activity and phospholipid binding activity. Predicted to be involved in clathrin coat assembly and clathrin-dependent endocytosis. Located in cytoplasm. Is expressed in adult head. Human ortholog(s) of this gene implicated in primary immunodeficiency disease. Orthologous to several human genes including FCHO2 (FCH and mu domain containing endocytic adaptor 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG8176 in Genome Data Viewer
    Location:
    85D19-85D19; 3-48 cM
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (9516007..9527237)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (5341729..5352959)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Ras oncogene at 85D Neighboring gene Rlb1 Neighboring gene mitochondrial ribosomal protein L47 Neighboring gene mir-2283 stem loop Neighboring gene Lysine demethylase 3 Neighboring gene blistery Neighboring gene murashka Neighboring gene long non-coding RNA:CR42549

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A mutational analysis of the endophilin-A N-BAR domain performed in living flies. Jung AG, et al. PLoS One, 2010 Mar 3. PMID 20209138, Free PMC Article
    2. A candidate loss-of-function variant in SGIP1 causes synaptic dysfunction and recessive parkinsonism. Decet M, et al. Cell Rep Med, 2024 Oct 15. PMID 39332416, Free PMC Article
    3. Drosophila F-BAR protein Syndapin contributes to coupling the plasma membrane and contractile ring in cytokinesis. Takeda T, et al. Open Biol, 2013 Aug 7. PMID 23926047, Free PMC Article
    4. Fusion pore dynamics of large secretory vesicles define a distinct mechanism of exocytosis. Biton T, et al. J Cell Biol, 2023 Nov 6. PMID 37707500, Free PMC Article
    5. Autonomous transposons tune their sequences to ensure somatic suppression. Ilık İA, et al. Nature, 2024 Feb. PMID 38355802, Free PMC Article

    See all (37) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables AP-2 adaptor complex binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables phospholipid binding ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in clathrin coat assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in clathrin-dependent endocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in clathrin-dependent endocytosis ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    is_active_in clathrin-coated pit IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in clathrin-coated pit ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in clathrin-coated vesicle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG8176-PA
    CG8176-PC
    CG8176-PE
    CG8176-PF
    CG8176-PG

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      9516007..9527237
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001104254.2 → NP_001097724.2  uncharacterized protein Dmel_CG8176, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001097724.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      A8JQW1, Q6AWD5
      Conserved Domains (3) summary
      cd07648
      Location:11 → 269
      F-BAR_FCHO; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of FCH domain Only proteins
      cd09265
      Location:928 → 1194
      AP_Syp1_like_MHD; Mu-homology domain (MHD) of endocytic adaptor protein (AP), Syp1
      pfam01442
      Location:52 → 214
      Apolipoprotein; Apolipoprotein A1/A4/E domain

    2. NM_176436.2 → NP_788613.2  uncharacterized protein Dmel_CG8176, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_788613.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8INN8, Q8T035, Q9VHC4
      Conserved Domains (3) summary
      cd07648
      Location:11 → 269
      F-BAR_FCHO; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of FCH domain Only proteins
      cd09265
      Location:841 → 1107
      AP_Syp1_like_MHD; Mu-homology domain (MHD) of endocytic adaptor protein (AP), Syp1
      pfam01442
      Location:52 → 214
      Apolipoprotein; Apolipoprotein A1/A4/E domain

    3. NM_001275490.1 → NP_001262419.1  uncharacterized protein Dmel_CG8176, isoform G [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001262419.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4KFZ2
      Conserved Domains (3) summary
      cd07648
      Location:11 → 269
      F-BAR_FCHO; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of FCH domain Only proteins
      cd09265
      Location:869 → 1135
      AP_Syp1_like_MHD; Mu-homology domain (MHD) of endocytic adaptor protein (AP), Syp1
      pfam01442
      Location:52 → 214
      Apolipoprotein; Apolipoprotein A1/A4/E domain

    4. NM_001104253.3 → NP_001097723.1  uncharacterized protein Dmel_CG8176, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001097723.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A8JQW1, Q6AWD5
      Conserved Domains (3) summary
      cd07648
      Location:11 → 269
      F-BAR_FCHO; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of FCH domain Only proteins
      cd09265
      Location:928 → 1194
      AP_Syp1_like_MHD; Mu-homology domain (MHD) of endocytic adaptor protein (AP), Syp1
      pfam01442
      Location:52 → 214
      Apolipoprotein; Apolipoprotein A1/A4/E domain

    5. NM_176435.3 → NP_788612.1  uncharacterized protein Dmel_CG8176, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_788612.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8INN8, Q8T035, Q9VHC4
      Related
      FBpp0081543
      Conserved Domains (3) summary
      cd07648
      Location:11 → 269
      F-BAR_FCHO; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of FCH domain Only proteins
      cd09265
      Location:841 → 1107
      AP_Syp1_like_MHD; Mu-homology domain (MHD) of endocytic adaptor protein (AP), Syp1
      pfam01442
      Location:52 → 214
      Apolipoprotein; Apolipoprotein A1/A4/E domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4KFZ2 A0A0B4KFZ2
    Q6AWD5 Q6AWD5
    Q8T035 Q8T035
    Q9VHC4 Q9VHC4

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