cav caravaggio [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: cavprovided by FlyBase
Official Full Name: caravaggioprovided by FlyBase
Primary source: FLYBASE:FBgn0026257
Locus tag: Dmel_CG6219
See related: AllianceGenome:FB:FBgn0026257
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: 1G5; anon fe 1G5; anon-EST:fe1G5; anon1G5; Anon1G5; Caravaggio; Cav; cav/HOAP; Cav/HOAP; CG6219; Dmel\CG6219; hoap; Hoap; HOAP; p55
Summary: Enables telomeric DNA binding activity. Involved in telomere capping. Located in chromosome, centromeric region; chromosome, telomeric region; and nucleus. Part of telomere cap complex. Is expressed in several structures, including central brain primordium; head mesoderm; salivary gland; trunk mesoderm; and ventral nerve cord primordium. [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3R	NT_033777.3 (24221103..24223528)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3R	NT_033777.2 (20046825..20049250)

Chromosome 3R - NT_033777.3 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Drosophila telomere capping protein HOAP interacts with DSB sensor proteins Mre11 and Nbs.
Title: Drosophila telomere capping protein HOAP interacts with DSB sensor proteins Mre11 and Nbs.
Adaptive evolution of an essential telomere protein restricts telomeric retrotransposons.
Title: Adaptive evolution of an essential telomere protein restricts telomeric retrotransposons.
genetic and biochemical assays indicate a repressing activity for HOAP
Title: Cooperative and antagonistic contributions of two heterochromatin proteins to transcriptional regulation of the Drosophila sex determination decision.
HOAP interacts with Umbrea with functional role in mediating normal telomere behaviour in Drosophila
Title: Umbrea, a chromo shadow domain protein in Drosophila melanogaster heterochromatin, interacts with Hip, HP1 and HOAP.
Drosophila modigliani (moi) gene encodes a HOAP-interacting protein required for telomere protection
Title: The Drosophila modigliani (moi) gene encodes a HOAP-interacting protein required for telomere protection.
HOAP-depleted telomeres activate both the DNA-damage response and the spindle assembly checkpoint.
Title: Unprotected Drosophila melanogaster telomeres activate the spindle assembly checkpoint.
HOAP has a role in functional centric heterochromatin
Title: Novel Drosophila heterochromatin protein 1 (HP1)/origin recognition complex-associated protein (HOAP) repeat motif in HP1/HOAP interactions and chromocenter associations.

Submit: New GeneRIF Correction

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables structural constituent of ribosome	IEA Inferred from Electronic Annotation more info
enables telomeric DNA binding	IMP Inferred from Mutant Phenotype more info	PubMed

Process	Evidence Code	Pubs
involved_in telomere capping	IEP Inferred from Expression Pattern more info	PubMed
involved_in telomere capping	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in telomere maintenance	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in chromosome, centromeric region	IDA Inferred from Direct Assay more info	PubMed
located_in chromosome, telomeric region	IDA Inferred from Direct Assay more info	PubMed
part_of mitochondrial small ribosomal subunit	IEA Inferred from Electronic Annotation more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
part_of telomere cap complex	IDA Inferred from Direct Assay more info	PubMed

Names: CG6219-PA; CG6219-PB; CG6219-PD; CG6219-PE; HP1 and Orc-associated protein; HP1-ORC associated protein; HP1/ORC-associated protein; anon-fast-evolving-1G5; anonymous fast evolving gene IG5; cav-PA; cav-PB; cav-PD; cav-PE; drosophila anonymous fast evolving 1G5