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    CG3744 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 42972, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG3744provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0039240
    Locus tag
    Dmel_CG3744
    See related
    AllianceGenome:FB:FBgn0039240
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Dmel\CG3744
    Summary
    Predicted to enable dipeptidyl-peptidase activity. Predicted to be involved in proteolysis. Human ortholog(s) of this gene implicated in primary immunodeficiency disease. Orthologous to human DPP8 (dipeptidyl peptidase 8) and DPP9 (dipeptidyl peptidase 9). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG3744 in Genome Data Viewer
    Location:
    96B2-96B2; 3-86 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (24871202..24876654, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (20696924..20702376, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Elastin-like Neighboring gene Cyclin B3 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Identification and partial characterization of the enzyme of omega: one of five putative DPP IV genes in Drosophila melanogaster. Chihara CJ, et al. J Insect Sci, 2005 Nov 2. PMID 17119608, Free PMC Article
    2. Nicastrin controls aspects of photoreceptor neuron specification and differentiation in the Drosophila eye. Zhang T, et al. Dev Dyn, 2005 Nov. PMID 16145661
    3. A GATA/RUNX cis-regulatory module couples Drosophila blood cell commitment and differentiation into crystal cells. Ferjoux G, et al. Dev Biol, 2007 May 15. PMID 17418114
    4. Comparison of parallel high-throughput RNA sequencing between knockout of TDP-43 and its overexpression reveals primarily nonreciprocal and nonoverlapping gene expression changes in the central nervous system of Drosophila. Hazelett DJ, et al. G3 (Bethesda), 2012 Jul. PMID 22870402, Free PMC Article
    5. siRNA screen identifies QPCT as a druggable target for Huntington's disease. Jimenez-Sanchez M, et al. Nat Chem Biol, 2015 May. PMID 25848931, Free PMC Article

    See all (29) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables dipeptidyl-peptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables serine-type peptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in proteolysis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG3744-PD
    CG3744-PE
    CG3744-PF
    CG3744-PG
    NP_001262935.1
    NP_651304.3
    NP_733056.3
    NP_996292.2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      24871202..24876654 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_170177.3 → NP_733056.3  uncharacterized protein Dmel_CG3744, isoform G [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_733056.3

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0C4FEI9, Q9VC19
      Conserved Domains (3) summary
      COG1506
      Location:838 → 1099
      DAP2; Dipeptidyl aminopeptidase/acylaminoacyl peptidase [Amino acid transport and metabolism]
      pfam00326
      Location:902 → 1101
      Peptidase_S9; Prolyl oligopeptidase family
      pfam00930
      Location:419 → 802
      DPPIV_N; Dipeptidyl peptidase IV (DPP IV) N-terminal region

    2. NM_143047.3 → NP_651304.3  uncharacterized protein Dmel_CG3744, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_651304.3

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0C4FEI9, Q8IH07, Q9VC20
      Conserved Domains (3) summary
      COG1506
      Location:778 → 1039
      DAP2; Dipeptidyl aminopeptidase/acylaminoacyl peptidase [Amino acid transport and metabolism]
      pfam00326
      Location:842 → 1041
      Peptidase_S9; Prolyl oligopeptidase family
      pfam00930
      Location:359 → 742
      DPPIV_N; Dipeptidyl peptidase IV (DPP IV) N-terminal region

    3. NM_001276006.1 → NP_001262935.1  uncharacterized protein Dmel_CG3744, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001262935.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0C4FEI9, Q9VC19
      Conserved Domains (3) summary
      COG1506
      Location:838 → 1099
      DAP2; Dipeptidyl aminopeptidase/acylaminoacyl peptidase [Amino acid transport and metabolism]
      pfam00326
      Location:902 → 1101
      Peptidase_S9; Prolyl oligopeptidase family
      pfam00930
      Location:419 → 802
      DPPIV_N; Dipeptidyl peptidase IV (DPP IV) N-terminal region

    4. NM_206569.2 → NP_996292.2  uncharacterized protein Dmel_CG3744, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_996292.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0C4FEI9, Q8IH07, Q9VC20
      Conserved Domains (3) summary
      COG1506
      Location:778 → 1039
      DAP2; Dipeptidyl aminopeptidase/acylaminoacyl peptidase [Amino acid transport and metabolism]
      pfam00326
      Location:842 → 1041
      Peptidase_S9; Prolyl oligopeptidase family
      pfam00930
      Location:359 → 742
      DPPIV_N; Dipeptidyl peptidase IV (DPP IV) N-terminal region
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0C4FEI9 A0A0C4FEI9
    Q9VC19 Q9VC19
    Q9VC20 Q9VC20

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